All Stories

  1. Hypoglycemic Properties of Leccinum scabrum Extracts—An In Vitro Study on α-Glucosidase and α-Amylase Inhibition and Metabolic Profile Determination

    Article • Journal of Fungi, October 2024, MDPI AG

    Giovanni Lentini

  2. Lentil Waste Extracts for Inflammatory Bowel Disease (IBD) Symptoms Control: Anti-Inflammatory and Spasmolytic Effects

    Article • Nutrients, September 2024, MDPI AG

    Giovanni Lentini

  3. Antiviral Properties of Moringa oleifera Leaf Extracts against Respiratory Viruses

    Article • Viruses, July 2024, MDPI AG

    Giovanni Lentini

  4. Drug Repositioning for Ovarian Cancer Treatment: An Update

    Article • Anti-Cancer Agents in Medicinal Chemistry, May 2024, Bentham Science Publishers

    Giovanni Lentini

  5. Molecular Insights into the Rescue Mechanism of an hERG Activator Against Severe LQT2 Mutations

    Article • March 2024, Cold Spring Harbor Laboratory Press

    Giovanni Lentini

  6. Antipsychotics: 70 Years

    Article • Biomedicines, November 2023, MDPI AG

    Giovanni Lentini

  7. A Comparative Study of the Inhibitory Action of Berberine Derivatives on the Recombinant Protein FtsZ of E. coli

    Article • International Journal of Molecular Sciences, March 2023, MDPI AG

    Giovanni Lentini

  8. Endocannabinoid Degradation Enzyme Inhibitors as Potential Antipsychotics: A Medicinal Chemistry Perspective

    Article • Biomedicines, February 2023, MDPI AG

    Giovanni Lentini

  9. Biostimulant Formulations and Moringa oleifera Extracts to Improve Yield, Quality, and Storability of Hydroponic Lettuce

    Article • Molecules, January 2023, MDPI AG

    Giovanni Lentini

  10. Camel (Camelus spp.) Urine Bioactivity and Metabolome: A Systematic Review of Knowledge Gaps, Advances, and Directions for Future Research

    Article • International Journal of Molecular Sciences, November 2022, MDPI AG

    Giovanni Lentini

  11. Lubeluzole Repositioning as Chemosensitizing Agent on Multidrug-Resistant Human Ovarian A2780/DX3 Cancer Cells

    Article • Molecules, November 2022, MDPI AG

    Giovanni Lentini

  12. Microwave-Assisted Extraction of Bioactive Compounds from Lentil Wastes: Antioxidant Activity Evaluation and Metabolomic Characterization

    Article • Molecules, November 2022, MDPI AG

    Giovanni Lentini

  13. Camel urine limits proliferation and modifies cell morphology in human renal tumoral and non-tumoral cells

    Article • September 2022, Cold Spring Harbor Laboratory Press

    Giovanni Lentini

  14. Personalized Medicine in Mitochondrial Health and Disease: Molecular Basis of Therapeutic Approaches Based on Nutritional Supplements and Their Analogs

    Article • Molecules, May 2022, MDPI AG

    Giovanni Lentini

  15. Corrigendum: Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use‐Dependent Inhibitors of Voltage‐Gated Sodium Channels

    Article • ChemMedChem, March 2022, Wiley

    Giovanni Lentini

  16. Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use‐Dependent Inhibitors of Voltage‐Gated Sodium Channels

    Article • ChemMedChem, October 2021, Wiley

    Giovanni Lentini

  17. Functionalized Dendrimer Platforms as a New Forefront Arsenal Targeting SARS-CoV-2: An Opportunity

    Article • Pharmaceutics, September 2021, MDPI AG

    Giovanni Lentini

  18. Structure-Based Prediction of hERG-Related Cardiotoxicity: A Benchmark Study

    Article • Journal of Chemical Information and Modeling, September 2021, American Chemical Society (ACS)

    Giovanni Lentini

  19. Densely Functionalized 2-Methylideneazetidines: Evaluation as Antibacterials

    Article • Molecules, June 2021, MDPI AG

    Giovanni Lentini

  20. Xanthenylacetic Acid Derivatives Effectively Target Lysophosphatidic Acid Receptor 6 to Inhibit Hepatocellular Carcinoma Cell Growth

    Article • ChemMedChem, June 2021, Wiley

    Giovanni Lentini

  21. Inverse Virtual Screening for the rapid re-evaluation of the presumed biological safe profile of natural products. The case of steviol from Stevia rebaudiana glycosides on farnesoid X receptor (FXR)

    Article • Bioorganic Chemistry, June 2021, Elsevier

    Giovanni Lentini

  22. Molecular Simplification of Natural Products: Synthesis, Antibacterial Activity, and Molecular Docking Studies of Berberine Open Models

    Article • Biomedicines, April 2021, MDPI AG

    Giovanni Lentini

  23. Targeting Penicillium expansum GMC Oxidoreductase with High Affinity Small Molecules for Reducing Patulin Production

    Article • Biology, December 2020, MDPI AG

    Giovanni Lentini

  24. Ultrasound and deep eutectic solvents: An efficient combination to tune the mechanism of steviol glycosides extraction

    Article • Ultrasonics Sonochemistry, December 2020, Elsevier

    Giovanni Lentini

  25. Synthesis and Evaluation of Voltage‐Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities

    Article • ChemMedChem, October 2020, Wiley

    Giovanni Lentini

  26. Lubeluzole: from anti-ischemic drug to preclinical antidiarrheal studies

    Article • Pharmacological Reports, October 2020, Springer Science + Business Media

    Giovanni Lentini

  27. From Riluzole to Dexpramipexole via Substituted-Benzothiazole Derivatives for Amyotrophic Lateral Sclerosis Disease Treatment: Case Studies

    Article • Molecules, July 2020, MDPI AG

    Giovanni Lentini

  28. COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help

    Article • Molecules, April 2020, MDPI AG

    Giovanni Lentini

  29. Repurposing therapeutic agents and herbal medicines to defeat viral nemesis

    Article • Drug Development Research, March 2020, Wiley

    Giovanni Lentini

  30. Targeting the pregnane X receptor using microbial metabolite mimicry

    Article • EMBO Molecular Medicine, March 2020, EMBO

    Giovanni Lentini

  31. Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design

    Article • Drug Discovery Today, February 2020, Elsevier

    Giovanni Lentini

  32. Optimization of Microwave-Assisted Extraction of Antioxidants from Bamboo Shoots of Phyllostachys pubescens

    Article • Molecules, January 2020, MDPI AG

    Giovanni Lentini

  33. Novel lysophosphatidic acid receptor 6 antagonists inhibit hepatocellular carcinoma growth through affecting mitochondrial function

    Article • Journal of Molecular Medicine, December 2019, Springer Science + Business Media

    Giovanni Lentini

  34. Structure-Based Identification and Design of Angiotensin Converting Enzyme-Inhibitory Peptides from Whey Proteins

    Article • Journal of Agricultural and Food Chemistry, December 2019, American Chemical Society (ACS)

    Giovanni Lentini

  35. Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry

    Article • October 2019, Cold Spring Harbor Laboratory Press

    Giovanni Lentini

  36. The therapeutic power of green

    Article • Schizophrenia Research, July 2019, Elsevier

    Giovanni Lentini

  37. Comment on “In Situ Derivatization of (RS)-Mexiletine and Enantioseparation Using Micellar Liquid Chromatography: A Green Approach”

    Article • ACS Sustainable Chemistry & Engineering, March 2019, American Chemical Society (ACS)

    Giovanni Lentini

  38. (S)-Ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate

    Article • Molbank, February 2019, MDPI AG

    Giovanni Lentini

  39. A Focus on the Synthesis and Pharmacokinetics of Tocainide and its Analogues

    Article • Current Medicinal Chemistry, February 2019, Bentham Science Publishers

    Giovanni Lentini

  40. The Crystal Structure of N-[(2E)-3-(4-Chlorophenyl)prop-2-en-1-yl]-4-methoxy-N-methylbenzenesulfonamide

    Article • Journal of Chemical Crystallography, October 2018, Springer Science + Business Media

    Giovanni Lentini

  41. Antimicrobial and Antibiofilm Activities of Citrus Water-Extracts Obtained by Microwave-Assisted and Conventional Methods

    Article • Biomedicines, June 2018, MDPI AG

    Giovanni Lentini

  42. Plant-Derived Anticancer Agents: Lessons from the Pharmacology of Geniposide and Its Aglycone, Genipin

    Article • Biomedicines, March 2018, MDPI AG

    Giovanni Lentini

  43. Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential

    Article • Frontiers in Pharmacology, January 2018, Frontiers

    Giovanni Lentini

  44. Positional isomers of mannose–quinoline conjugates and their copper complexes: exploring the biological activity

    Article • New Journal of Chemistry, January 2018, Royal Society of Chemistry

    Giovanni Lentini

  45. Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole

    Article • Cellular Physiology and Biochemistry, January 2018, Karger Publishers

    Dr Francesco Tadini-Buoninsegni, Giovanni Lentini

  46. Discovery of a new mexiletine-derived agonist of the hERG K + channel

    Article • Biophysical Chemistry, October 2017, Elsevier

    Giovanni Lentini, Dr Francesco Tadini-Buoninsegni

  47. A Mini-Review on Thalidomide: Chemistry, Mechanisms of Action, Therapeutic Potential and Anti-Angiogenic Properties in Multiple Myeloma

    Article • Current Medicinal Chemistry, September 2017, Bentham Science Publishers

    Giovanni Lentini

  48. Nitro-substituted tetrahydroindolizines and homologs: Design, kinetics, and mechanism of α-glucosidase inhibition

    Article • Bioorganic & Medicinal Chemistry Letters, September 2017, Elsevier

    Giovanni Lentini

  49. Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective

    Article • Expert Opinion on Drug Discovery, August 2017, Taylor & Francis

    Giovanni Lentini

  50. The trivial names of citrus limonoids

    Article • Food Chemistry, June 2017, Elsevier

    Giovanni Lentini

  51. New doxorubicin nanocarriers based on cyclodextrins

    Article • Investigational New Drugs, April 2017, Springer Science + Business Media

    Dr Mattia Rocco, Giovanni Lentini

  52. 2-Arylazetidines as ligands for nicotinic acetylcholine receptors

    Article • Chemistry of Heterocyclic Compounds, March 2017, Springer Science + Business Media

    Giovanni Lentini

  53. Old Drug Scaffold, New Activity: Thalidomide-Correlated Compounds Exert Different Effects on Breast Cancer Cell Growth and Progression

    Article • ChemMedChem, January 2017, Wiley

    Giovanni Lentini

  54. Synthesis and evaluation of berberine derivatives and analogs as potential antiacetylcholinesterase and antioxidant agents

    Article • Phytochemistry Letters, December 2016, Elsevier

    Giovanni Lentini

  55. The Chemistry and Pharmacology of Citrus Limonoids

    Article • Molecules, November 2016, MDPI AG

    Giovanni Lentini

  56. Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues

    Article • European Journal of Medicinal Chemistry, October 2016, Elsevier

    Giovanni Lentini

  57. Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules

    Article • ChemMedChem, November 2015, Wiley

    Giovanni Lentini

  58. Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine

    Article • Pharmacology Research & Perspectives, July 2015, Wiley

    Dr Francesco Tadini-Buoninsegni, Giovanni Lentini

  59. The Therapeutic Potential of Rutin for Diabetes: An Update

    Article • Mini-Reviews in Medicinal Chemistry, April 2015, Bentham Science Publishers

    Giovanni Lentini

  60. Plotting intersections

    Article • Nature Methods, April 2015, Springer Science + Business Media

    Giovanni Lentini

  61. Did Ebola Survivors Use Plant Medicines, and if so, Which Ones?

    Article • Phytotherapy Research, January 2015, Wiley

    Giovanni Lentini

  62. Ebola therapy: Developing new drugs or repurposing old ones?

    Article • International Journal of Cardiology, January 2015, Elsevier

    Giovanni Lentini

  63. Microchip capillary electrophoresis–electrospray ionization mass spectrometry analysis of paracetamol metabolites in human urine: An intriguing case

    Article • Journal of Chromatography A, January 2014, Elsevier

    Giovanni Lentini

  64. Recent Trends and Future Prospects in Computational GPCR Drug Discovery: From Virtual Screening to Polypharmacology

    Article • Current Topics in Medicinal Chemistry, May 2013, Bentham Science Publishers

    Giovanni Lentini

  65. Stereospecific Synthesis of m-Hydroxymexiletine Enantiomers

    Article • Drug Metabolism Letters, March 2013, Bentham Science Publishers

    Giovanni Lentini

  66. Microwave-Assisted Synthesis of(±)-Mandelic Acid-d5, Optical Resolution, and Absolute Configuration Determination

    Article • Journal of Chemistry, January 2013, Hindawi Publishing Corporation

    Giovanni Lentini

  67. An Improved Synthesis of m-Hydroxymexiletine, a Potent Mexiletine Metabolite

    Article • Drug Metabolism Letters, June 2012, Bentham Science Publishers

    Giovanni Lentini

  68. Crystal structure of N-(2-{[(2E)-3-(4-chlorophenyl)-2-propenyl]- (methyl)ammonio}methylphenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide dihydrogen phosphate — methanol (1:1), [C26H30ClN2SO4][H2PO4] · CH4O

    Article • Zeitschrift für Kristallographie - New Crystal Structures, January 2012, De Gruyter

    Giovanni Lentini

  69. Hydroxylated Analogs of Mexiletine as Tools for Structural-Requirements Investigation of the Sodium Channel Blocking Activity

    Article • Archiv der Pharmazie, June 2010, Wiley

    Giovanni Lentini

  70. Fpocket: An open source platform for ligand pocket detection

    Article • BMC Bioinformatics, January 2009, Springer Science + Business Media

    Giovanni Lentini

  71. Facile Entry to Ethyl Tetrahydro-1H-pyrrolizin-7a(5H)-ylacetate: a Versatile Pharmaceutical Intermediate

    Article • Heterocycles, January 2008, Japan Institute of Heterocyclic Chemistry

    Giovanni Lentini

  72. Synthesis of (R)-, (S)-, and (RS)-hydroxymethylmexiletine, one of the major metabolites of mexiletine

    Article • Tetrahedron Asymmetry, October 2007, Elsevier

    Giovanni Lentini

  73. Synthesis and Biological Evaluation of Chiral α-Aminoanilides with Central Antinociceptive Activity

    Article • Journal of Medicinal Chemistry, April 2007, American Chemical Society (ACS)

    Giovanni Lentini

  74. Facile, alternative route to Lubeluzole, its enantiomer, and the racemate

    Article • Chirality, January 2006, Wiley

    Giovanni Lentini

  75. Optically Active Mexiletine Analogues as Stereoselective Blockers of Voltage-Gated Na+Channels.

    Article • Journal of Medicinal Chemistry, April 2005, American Chemical Society (ACS)

    Giovanni Lentini

  76. Erratum to Alessia Catalano, Alessia Carocci, Giuseppe Fracchiolla, Carlo Franchini, Giovanni Lentini, Vincenzo Tortorella, Annamaria De Luca, Michela De Bellis, Jean-Francois Desaphy, Diana Conte Camerino, "Stereospecific synthesis of para-hydroxymexi...

    Article • Chirality, January 2005, Wiley

    Giovanni Lentini

  77. Stereospecific synthesis of mexiletine and related compounds: Mitsunobu versus Williamson reaction

    Article • Tetrahedron Asymmetry, September 2000, Elsevier

    Giovanni Lentini

  78. Stereoselective effects of mexiletine enantiomers on sodium currents and excitability characteristics of adult skeletal muscle fibers

    Article • Naunyn-Schmiedeberg s Archives of Pharmacology, December 1995, Springer Science + Business Media

    Giovanni Lentini

  79. Stereospecific synthesis and absolute configuration of mexiletine

    Article • Chirality, January 1994, Wiley

    Giovanni Lentini

  80. Stereoselectivity in central analgesic action of tocainide and its analogs

    Article • Chirality, January 1993, Wiley

    Giovanni Lentini

  81. Pharmacological differences between R(-) and S(+) tocainide*1

    Article • Pharmacological Research, September 1992, Elsevier

    Giovanni Lentini

  82. The effects of tocainide and its chiral analogs on sodium channels of human muscle

    Article • Pharmacological Research, October 1990, Elsevier

    Giovanni Lentini