All Stories

  1. High-content assay for CFTR monitoring: simultaneous quantification of channel function and biogenesis

    Article • May 2019, Cold Spring Harbor Laboratory Press

    Dr Paola Vergani

  2. Structure, Gating, and Regulation of the CFTR Anion Channel

    Article • Physiological Reviews, January 2019, American Physiological Society

    Dr Paola Vergani

  3. CFTR potentiation by VX-770 involves stabilization of the pre-hydrolytic, O1 state

    Article • British Journal of Pharmacology, August 2018, Wiley

    Dr Paola Vergani

  4. Structure of Transmembrane Helix 8 and Possible Membrane Defects in CFTR

    Article • Biophysical Journal, April 2018, Elsevier

    Dr Paola Vergani

  5. Improved fluorescence assays to measure the defects associated with F508del-CFTR allow identification of new active compounds

    Article • British Journal of Pharmacology, February 2017, Wiley

    Dr Paola Vergani, Dr Emily Langron, David Selwood

  6. Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases

    Article • Journal of Medicinal Chemistry, February 2017, American Chemical Society (ACS)

    Dr Emily Langron, Dr Paola Vergani, Johan Neyts

  7. Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

    Article • Journal of Biological Chemistry, July 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Paola Vergani

  8. Increased apical Na+permeability in cystic fibrosis is supported by a quantitative model of epithelial ion transport

    Article • The Journal of Physiology, July 2013, Wiley

    Dr Paola Vergani

  9. Conformational changes in the catalytically inactive nucleotide-binding site of CFTR

    Article • Journal of General Physiology, June 2013, Rockefeller University Press

    Dr Paola Vergani

  10. Mutant cycles at CFTR’s non-canonical ATP-binding site support little interface separation during gating

    Article • Journal of General Physiology, May 2011, Rockefeller University Press

    Dr Paola Vergani

  11. Electrophysiological, Biochemical, and Bioinformatic Methods for Studying CFTR Channel Gating and Its Regulation

    Article • January 2011, Springer Science + Business Media

    Dr Paola Vergani

  12. Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2

    Article • Journal of General Physiology, September 2010, Rockefeller University Press

    Dr Paola Vergani

  13. Strict coupling between CFTR’s catalytic cycle and gating of its Cl − ion pore revealed by distributions of open channel burst durations

    Article • Proceedings of the National Academy of Sciences, December 2009, Proceedings of the National Academy of Sciences

    Dr Paola Vergani

  14. ATP hydrolysis-driven gating in cystic fibrosis transmembrane conductance regulator

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, January 2009, Royal Society Publishing

    Dr Paola Vergani

  15. In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer

    Article • The EMBO Journal, October 2006, Wiley

    Dr Paola Vergani

  16. The ABC protein turned chloride channel whose failure causes cystic fibrosis

    Article • Nature, March 2006, Springer Science + Business Media

    Dr Paola Vergani

  17. Control of the CFTR channel's gates

    Article • Biochemical Society Transactions, October 2005, Portland Press Ltd.

    Dr Paola Vergani

  18. CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains

    Article • Nature, February 2005, Springer Science + Business Media

    Dr Paola Vergani

  19. Prolonged Nonhydrolytic Interaction of Nucleotide with CFTR's NH2-terminal Nucleotide Binding Domain and its Role in Channel Gating

    Article • Journal of General Physiology, August 2003, Rockefeller University Press

    Dr Paola Vergani

  20. On the Mechanism of MgATP-dependent Gating of CFTR Cl−Channels

    Article • Journal of General Physiology, December 2002, Rockefeller University Press

    Dr Paola Vergani

  21. Mutations in the yeast two pore K+channel YKC1 identify functional differences between the pore domains

    Article • FEBS Letters, September 1999, Wiley

    Dr Paola Vergani

  22. Mutations in the pore regions of the yeast K+ channel YKC1 affect gating by extracellular K+

    Article • The EMBO Journal, December 1998, Wiley

    Dr Paola Vergani

  23. Extracellular K+and Ba2+mediate voltage-dependent inactivation of the outward-rectifying K+channel encoded by the yeast geneTOK1

    Article • FEBS Letters, April 1997, Wiley

    Dr Paola Vergani

  24. Complementation of a yeast Δpkc1mutant by theArabidopsisprotein ANT

    Article • FEBS Letters, January 1997, Wiley

    Dr Paola Vergani