All Stories

  1. A Biomimetic, Copolymeric Membrane for Cell‐Stretch Experiments with Pulmonary Epithelial Cells at the Air‐Liquid Interface

    Article • Advanced Functional Materials, December 2020, Wiley

    Darcy Wagner

  2. Extracellular‐Matrix‐Reinforced Bioinks for 3D Bioprinting Human Tissue

    Article • Advanced Materials, December 2020, Wiley

    Darcy Wagner

  3. Inhibition of LTβR signalling activates WNT-induced regeneration in lung

    Article • Nature, November 2020, Springer Science + Business Media

    Darcy Wagner

  4. Isolation of high yield and quality RNA from human precision-cut lung slices for RNA-sequencing and computational integration with larger patient cohorts

    Article • AJP Lung Cellular and Molecular Physiology, October 2020, American Physiological Society

    Darcy Wagner

  5. KRAS signalling in malignant pleural mesothelioma

    Article • October 2020, Cold Spring Harbor Laboratory Press

    Darcy Wagner

  6. Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019

    Article • ERJ Open Research, October 2020, European Respiratory Society (ERS)

    Dr Amy L Ryan, Darcy Wagner

  7. Technological advances in study of lung regenerative medicine:perspective from the 2019 Vermont lung stem cell conference

    Article • Cytotherapy, October 2020, Elsevier

    Darcy Wagner

  8. Lung regeneration: implications of the diseased niche and ageing

    Article • European Respiratory Review, September 2020, European Respiratory Society (ERS)

    Darcy Wagner

  9. Fostering the integration of basic respiratory science and translational pulmonary medicine for the future

    Article • AJP Lung Cellular and Molecular Physiology, September 2020, American Physiological Society

    Darcy Wagner

  10. Isolation of high yield and quality RNA from human precision-cut lung slices for RNA-sequencing and computational integration with larger patient cohorts

    Article • August 2020, Cold Spring Harbor Laboratory Press

    Darcy Wagner

  11. Applications and Approaches for Three-Dimensional Precision-Cut Lung Slices. Disease Modeling and Drug Discovery

    Article • American Journal of Respiratory Cell and Molecular Biology, June 2020, American Thoracic Society

    Darcy Wagner

  12. Collagen IV: a critical new starting point for engineering upper airways

    Article • European Respiratory Journal, June 2020, European Respiratory Society (ERS)

    Darcy Wagner

  13. CORRIGENDUM

    Article • AJP Lung Cellular and Molecular Physiology, April 2020, American Physiological Society

    Darcy Wagner

  14. Increased particle flow rate from airways precedes clinical signs of ARDS in a porcine model of LPS-induced acute lung injury

    Article • AJP Lung Cellular and Molecular Physiology, March 2020, American Physiological Society

    Darcy Wagner

  15. Mechanically ventilated patients exhibit decreased particle flow in exhaled breath as compared to normal breathing patients

    Article • ERJ Open Research, January 2020, European Respiratory Society (ERS)

    Sandra Lindstedt, Darcy Wagner

  16. Clickable decellularized extracellular matrix as a new tool for building hybrid-hydrogels to model chronic fibrotic diseases in vitro

    Article • Journal of Materials Chemistry B, January 2020, Royal Society of Chemistry

    Darcy Wagner

  17. The Oncogene ECT2 Contributes to a Hyperplastic, Proliferative Lung Epithelial Cell Phenotype in Idiopathic Pulmonary Fibrosis

    Article • American Journal of Respiratory Cell and Molecular Biology, December 2019, American Thoracic Society

    Melanie Königshoff, Darcy Wagner

  18. Particle Flow Profiles From the Airways Measured by PExA Differ in Lung Transplant Recipients Who Develop Primary Graft Dysfunction

    Article • Experimental and Clinical Transplantation, December 2019, Baskent University

    Darcy Wagner

  19. Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases 2017. An Official American Thoracic Society Workshop Report

    Article • American Journal of Respiratory Cell and Molecular Biology, October 2019, American Thoracic Society

    Dr Laertis Ikonomou, Darcy Wagner

  20. Evolution of Bioengineered Lung Models: Recent Advances and Challenges in Tissue Mimicry for Studying the Role of Mechanical Forces in Cell Biology

    Article • Advanced Functional Materials, July 2019, Wiley

    Darcy Wagner

  21. Translating Basic Research into Safe and Effective Cell-based Treatments for Respiratory Diseases

    Article • Annals of the American Thoracic Society, June 2019, American Thoracic Society

    Dr Laertis Ikonomou, Darcy Wagner

  22. Club cells form lung adenocarcinomas and maintain the alveoli of adult mice

    Article • eLife, May 2019, eLife

    Darcy Wagner

  23. Generation of Human 3D Lung Tissue Cultures (3D-LTCs) for Disease Modeling

    Article • Journal of Visualized Experiments, February 2019, MyJove Corporation

    Darcy Wagner

  24. The Preparation of Decellularized Mouse Lung Matrix Scaffolds for Analysis of Lung Regenerative Cell Potential

    Article • January 2019, Springer Science + Business Media

    Darcy Wagner

  25. Increased Extracellular Vesicles Mediate WNT5A Signaling in Idiopathic Pulmonary Fibrosis

    Article • American Journal of Respiratory and Critical Care Medicine, December 2018, American Thoracic Society

    Melanie Königshoff, Darcy Wagner

  26. Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis

    Article • September 2018, Springer Science + Business Media

    Darcy Wagner

  27. Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis

    Article • Scientific Reports, August 2018, Springer Science + Business Media

    Darcy Wagner

  28. A new way of monitoring mechanical ventilation by measurement of particle flow from the airways using Pexa method in vivo and during ex vivo lung perfusion in DCD lung transplantation

    Article • Intensive Care Medicine Experimental, July 2018, Springer Science + Business Media

    Darcy Wagner

  29. Avian lungs: A novel scaffold for lung bioengineering

    Article • PLoS ONE, June 2018, PLOS

    Darcy Wagner

  30. How to build a lung: latest advances and emerging themes in lung bioengineering

    Article • European Respiratory Journal, June 2018, European Respiratory Society (ERS)

    Darcy Wagner

  31. Acellular human lung scaffolds to model lung disease and tissue regeneration

    Article • European Respiratory Review, June 2018, European Respiratory Society (ERS)

    Darcy Wagner

  32. Co-opting of ClinicalTrials.gov by patient-funded studies

    Article • The Lancet Respiratory Medicine, June 2018, Elsevier

    Dr Laertis Ikonomou, Darcy Wagner

  33. TGF-β1-induced deposition of provisional extracellular matrix by tracheal basal cells promotes epithelial-to-mesenchymal transition in a c-Jun NH2-terminal kinase-1-dependent manner

    Article • AJP Lung Cellular and Molecular Physiology, June 2018, American Physiological Society

    Darcy Wagner

  34. S100a4 Is Secreted by Alternatively Activated Alveolar Macrophages and Promotes Activation of Lung Fibroblasts in Pulmonary Fibrosis

    Article • Frontiers in Immunology, June 2018, Frontiers

    Darcy Wagner

  35. Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring

    Article • Nature Cell Biology, March 2018, Springer Science + Business Media

    Darcy Wagner

  36. Early Career Members at the ERS LSC 2017: mechanistic overlap between chronic lung injury and cancer

    Article • Breathe, November 2017, European Respiratory Society (ERS)

    Isaac Almendros, Dr. Sabine Bartel, Darcy Wagner

  37. Human Pulmonary 3D Models For Translational Research

    Article • Biotechnology Journal, September 2017, Wiley

    Darcy Wagner

  38. Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo

    Article • European Respiratory Journal, August 2017, European Respiratory Society (ERS)

    Melanie Königshoff, Darcy Wagner

  39. Reduced Frizzled Receptor 4 Expression Prevents WNT/β-Catenin–driven Alveolar Lung Repair in Chronic Obstructive Pulmonary Disease

    Article • American Journal of Respiratory and Critical Care Medicine, July 2017, American Thoracic Society

    Melanie Königshoff, Darcy Wagner

  40. An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices

    Article • AJP Lung Cellular and Molecular Physiology, June 2017, American Physiological Society

    Darcy Wagner

  41. Unproven Stem Cell Treatments for Lung Disease—An Emerging Public Health Problem

    Article • American Journal of Respiratory and Critical Care Medicine, April 2017, American Thoracic Society

    Dr Laertis Ikonomou, Darcy Wagner

  42. HeterozygousVangl2Looptailmice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair

    Article • Disease Models & Mechanisms, February 2017, The Company of Biologists

    David Long, Darcy Wagner

  43. Correction: Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD

    Article • Journal of Experimental Medicine, January 2017, Rockefeller University Press

    Prof. Dr. Ken R Bracke, Darcy Wagner

  44. Preparation of Decellularized Lung Matrices for Cell Culture and Protein Analysis

    Article • January 2017, Springer Science + Business Media

    Darcy Wagner

  45. Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD

    Article • Journal of Experimental Medicine, December 2016, Rockefeller University Press

    Darcy Wagner

  46. The Global Emergence of Unregulated Stem Cell Treatments for Respiratory Diseases. Professional Societies Need to Act

    Article • Annals of the American Thoracic Society, August 2016, American Thoracic Society

    Dr Laertis Ikonomou, Dr Darcy E Wagner, Dr Robert J Freishtat, Darcy Wagner

  47. An Official American Thoracic Society Workshop Report 2015. Stem Cells and Cell Therapies in Lung Biology and Diseases

    Article • Annals of the American Thoracic Society, August 2016, American Thoracic Society

    Dr Darcy E Wagner, Darcy Wagner

  48. Comparative Decellularization and Recellularization of Wild-Type and Alpha 1,3 Galactosyltransferase Knockout Pig Lungs: A Model for Ex Vivo Xenogeneic Lung Bioengineering and Transplantation

    Article • Tissue Engineering Part C Methods, August 2016, Mary Ann Liebert Inc

    Darcy Wagner

  49. Proteasome function in lung disease

    Article • American Journal of Respiratory and Critical Care Medicine, June 2016, American Thoracic Society

    Dr Silke Meiners, Darcy Wagner

  50. Residual Detergent Detection Method for Nondestructive Cytocompatibility Evaluation of Decellularized Whole Lung Scaffolds

    Article • Tissue Engineering Part C Methods, May 2016, Mary Ann Liebert Inc

    Dr Darcy E Wagner, Darcy Wagner

  51. A Computational Model of Cellular Engraftment on Lung Scaffolds

    Article • BioResearch Open Access, May 2016, Mary Ann Liebert Inc

    Darcy Wagner

  52. Decreased Laminin Expression by Human Lung Epithelial Cells and Fibroblasts Cultured in Acellular Lung Scaffolds from Aged Mice

    Article • PLoS ONE, March 2016, PLOS

    Dr Darcy E Wagner, Darcy Wagner

  53. CD11b+ and Sca-1+ Cells Exert the Main Beneficial Effects of Systemically Administered Bone Marrow-Derived Mononuclear Cells in a Murine Model of Mixed Th2/Th17 Allergic Airway Inflammation

    Article • Stem Cells Translational Medicine, March 2016, Wiley

    Darcy Wagner

  54. WISP1 mediates IL-6-dependent proliferation in primary human lung fibroblasts

    Article • Scientific Reports, February 2016, Springer Science + Business Media

    Darcy Wagner

  55. Systemic Administration of Human Bone Marrow-Derived Mesenchymal Stromal Cell Extracellular Vesicles AmelioratesAspergillusHyphal Extract-Induced Allergic Airway Inflammation in Immunocompetent Mice

    Article • Stem Cells Translational Medicine, September 2015, Wiley

    Darcy Wagner

  56. Preclinical validation and imaging of Wnt-induced repair in human 3D lung tissue cultures

    Article • European Respiratory Journal, April 2015, European Respiratory Society (ERS)

    Dr Darcy E Wagner, Melanie Königshoff, Darcy Wagner

  57. Freshly Thawed and Continuously Cultured Human Bone Marrow-Derived Mesenchymal Stromal Cells Comparably Ameliorate Allergic Airways Inflammation in Immunocompetent Mice

    Article • Stem Cells Translational Medicine, April 2015, Wiley

    Darcy Wagner

  58. An Official American Thoracic Society Workshop Report: Stem Cells and Cell Therapies in Lung Biology and Diseases

    Article • Annals of the American Thoracic Society, April 2015, American Thoracic Society

    Dr Darcy E Wagner, Darcy Wagner

  59. Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis

    Article • The EMBO Journal, July 2014, EMBO

    Juliana Barrios, Carla Kim, Darcy Wagner

  60. Three-dimensional scaffolds of acellular human and porcine lungs for high throughput studies of lung disease and regeneration

    Article • Biomaterials, March 2014, Elsevier

    Dr Darcy E Wagner, Darcy Wagner

  61. Comparative decellularization and recellularization of normal versus emphysematous human lungs

    Article • Biomaterials, March 2014, Elsevier

    Dr Darcy E Wagner, Darcy Wagner

  62. Design and Synthesis of an Artificial Pulmonary Pleura for High Throughput Studies in Acellular Human Lungs

    Article • Cellular and Molecular Bioengineering, February 2014, Springer Science + Business Media

    Dr Darcy E Wagner, Darcy Wagner

  63. Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis

    Article • The EMBO Journal, February 2014, Wiley

    Darcy Wagner

  64. Microwave-assisted solution combustion synthesis of high aspect ratio calcium phosphate nanoparticles

    Article • Journal of Materials Research, November 2013, Springer Science + Business Media

    Dr Darcy E Wagner, Darcy Wagner

  65. A microwave-assisted solution combustion synthesis to produce europium-doped calcium phosphate nanowhiskers for bioimaging applications

    Article • Acta Biomaterialia, September 2013, Elsevier

    Dr Darcy E Wagner, Darcy Wagner

  66. Can stem cells be used to generate new lungs?Ex vivolung bioengineering with decellularized whole lung scaffolds

    Article • Respirology, July 2013, Wiley

    Dr Darcy E Wagner, Darcy Wagner

  67. Cytocompatibility evaluation of microwave sintered biphasic calcium phosphate scaffolds synthesized using pH control

    Article • Materials Science and Engineering C, April 2013, Elsevier

    Dr Darcy E Wagner, Darcy Wagner

  68. The effects of storage and sterilization on de-cellularized and re-cellularized whole lung

    Article • Biomaterials, April 2013, Elsevier

    Dr Darcy E Wagner, Darcy Wagner

  69. The effect of age and emphysematous and fibrotic injury on the re-cellularization of de-cellularized lungs

    Article • Biomaterials, April 2013, Elsevier

    Darcy Wagner

  70. Progress and Outlook of Inorganic Nanoparticles for Delivery of Nucleic Acid Sequences Related to Orthopedic Pathologies: A Review

    Article • Tissue Engineering Part B Reviews, February 2012, Mary Ann Liebert Inc

    Dr Darcy E Wagner, Darcy Wagner

  71. Heat transfer in laminar flows of extended modified power law fluids in rectangular ducts

    Article • International Journal of Heat and Mass Transfer, January 2010, Elsevier

    Dr Darcy E Wagner, Darcy Wagner