All Stories

  1. Novel insights on the DNA interaction of calicheamicin γ 1 I

    Article • Biopolymers, May 2015, Wiley

    Professor Claudia Sissi

  2. Interactions of selected gold(iii) complexes with DNA G quadruplexes

    Article • Dalton Transactions, January 2015, Royal Society of Chemistry

    Professor Claudia Sissi

  3. Telomeric G-Quadruplex Architecture and Interactions with Potential Drugs

    Article • Current Pharmaceutical Design, October 2014, Bentham Science Publishers

    Professor Claudia Sissi

  4. DNA Targeting by Cationic Porphyrin–Ruthenium(II) Conjugates

    Article • ChemPlusChem, September 2014, Wiley

    Professor Claudia Sissi

  5. Sequencing and G-Quadruplex Folding of the Canine Proto-Oncogene KIT Promoter Region: Might Dog Be Used as a Model for Human Disease?

    Article • PLoS ONE, August 2014, PLOS

    Professor Claudia Sissi

  6. Novel Ametantrone–Amsacrine Related Hybrids as Topoisomerase IIβ Poisons and Cytotoxic Agents

    Article • Archiv der Pharmazie, July 2014, Wiley

    Professor Claudia Sissi

  7. Pt-based drugs: the spotlight will be on proteins

    Article • Metallomics, January 2014, Oxford University Press (OUP)

    Professor Claudia Sissi

  8. Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Professor Claudia Sissi

  9. Exploring the Chemical Space of G-Quadruplex Binders: Discovery of a Novel Chemotype Targeting the Human Telomeric Sequence

    Article • Journal of Medicinal Chemistry, November 2013, American Chemical Society (ACS)

    Professor Claudia Sissi

  10. Further SAR studies on bicyclic basic merbarone analogues as potent antiproliferative agents

    Article • Bioorganic & Medicinal Chemistry, November 2013, Elsevier

    Professor Claudia Sissi

  11. Metal ion and inter-domain interactions as functional networks in E. coli topoisomerase I

    Article • Gene, July 2013, Elsevier

    Professor Claudia Sissi

  12. Platinum-based drugs and proteins: Reactivity and relevance to DNA adduct formation

    Article • Journal of Inorganic Biochemistry, May 2013, Elsevier

    Professor Claudia Sissi

  13. Effect of G-Quadruplex Polymorphism on the Recognition of Telomeric DNA by a Metal Complex

    Article • PLoS ONE, March 2013, PLOS

    Professor Claudia Sissi

  14. Identification and Characterization of New DNA G-Quadruplex Binders Selected by a Combination of Ligand and Structure-Based Virtual Screening Approaches

    Article • Journal of Medicinal Chemistry, January 2013, American Chemical Society (ACS)

    Professor Claudia Sissi

  15. Ni2+ and Cu2+ complexes of a phenanthroline-based ligand bind to G-quadruplexes at non-overlapping sites

    Article • Chemical Communications, January 2013, Royal Society of Chemistry

    Professor Claudia Sissi

  16. Molecular Recognition of Human Telomeric DNA by Phenanthroline-Based G-Quadruplex Ligands

    Article • Open Journal of Medicinal Chemistry, January 2013, Scientific Research Publishing, Inc,

    Professor Claudia Sissi

  17. Structure–activity relationships of novel substituted naphthalene diimides as anticancer agents

    Article • European Journal of Medicinal Chemistry, November 2012, Elsevier

    Professor Claudia Sissi

  18. Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated DNA damage

    Article • Autophagy, August 2012, Taylor & Francis

    Professor Claudia Sissi

  19. Spectroscopic, Molecular Modeling, and NMR-Spectroscopic Investigation of the Binding Mode of the Natural Alkaloids Berberine and Sanguinarine to Human Telomeric G-Quadruplex DNA

    Article • ACS Chemical Biology, April 2012, American Chemical Society (ACS)

    Professor Claudia Sissi

  20. Folding Versus Charge: Understanding Selective Target Recognition by the Thrombin Aptamers

    Article • Current Pharmaceutical Design, March 2012, Bentham Science Publishers

    Professor Claudia Sissi

  21. Heterocyclic Dications as a New Class of Telomeric G-Quadruplex Targeting Agents

    Article • Current Pharmaceutical Design, March 2012, Bentham Science Publishers

    Professor Claudia Sissi

  22. Hybrid ligand–alkylating agents targeting telomeric G-quadruplex structures

    Article • Organic & Biomolecular Chemistry, January 2012, Royal Society of Chemistry

    Sara Richter, Professor Claudia Sissi

  23. Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases

    Article • Bioorganic & Medicinal Chemistry Letters, December 2011, Elsevier

    Professor Claudia Sissi

  24. Tuning G-Quadruplex vs Double-Stranded DNA Recognition in Regioisomeric Lysyl-Peptidyl-Anthraquinone Conjugates

    Article • Bioconjugate Chemistry, September 2011, American Chemical Society (ACS)

    Professor Claudia Sissi

  25. The evolving world of protein-G-quadruplex recognition: A medicinal chemist’s perspective

    Article • Biochimie, August 2011, Elsevier

    Professor Claudia Sissi

  26. DNA Reactivity Profile of trans‐Platinum Planar Amine Derivatives

    Article • ChemMedChem, April 2011, Wiley

    Professor Claudia Sissi

  27. Modeling and Biological Investigations of an Unusual Behavior of Novel Synthesized Acridine‐Based Polyamine Ligands in the Binding of Double Helix and G‐Quadruplex DNA

    Article • ChemMedChem, October 2010, Wiley

    Professor Claudia Sissi

  28. Remarkable interference with telomeric function by a G-quadruplex selective bisantrene regioisomer

    Article • Biochemical Pharmacology, June 2010, Elsevier

    Professor Claudia Sissi

  29. Rational Design, Synthesis, Biophysical and Antiproliferative Evaluation of Fluorenone Derivatives with DNA G‐Quadruplex Binding Properties

    Article • ChemMedChem, March 2010, Wiley

    Professor Claudia Sissi, Dr Francesco Paduano, Dr Francesco Paduano

  30. Phosphate diesters and DNA hydrolysis by dinuclear Zn(II) complexes featuring a disulfide bridge and H-bond donors

    Article • Tetrahedron, March 2010, Elsevier

    Professor Claudia Sissi

  31. In front of and behind the replication fork: bacterial type IIA topoisomerases

    Article • Cellular and Molecular Life Sciences, February 2010, Springer Science + Business Media

    Professor Claudia Sissi

  32. Simocyclinone D8 turns on against Gram-negative bacteria in a clinical setting

    Article • Bioorganic & Medicinal Chemistry Letters, February 2010, Elsevier

    Professor Claudia Sissi

  33. Quinone Methides Tethered to Naphthalene Diimides as Selective G-Quadruplex Alkylating Agents

    Article • Journal of the American Chemical Society, August 2009, American Chemical Society (ACS)

    Professor Claudia Sissi

  34. Metal ion-mediated assembly of effective phenanthroline-based G-quadruplex ligands

    Article • Dalton Transactions, January 2009, Royal Society of Chemistry

    Professor Claudia Sissi

  35. Phosphate Diester and DNA Hydrolysis by a Multivalent, Nanoparticle-Based Catalyst

    Article • Journal of the American Chemical Society, November 2008, American Chemical Society (ACS)

    Professor Claudia Sissi

  36. Perylene side chains modulate G-quadruplex conformation in biologically relevant DNA sequences

    Article • Bioorganic & Medicinal Chemistry, October 2008, Elsevier

    Professor Claudia Sissi

  37. DNA Gyrase Requires DNA for Effective Two-Site Coordination of Divalent Metal Ions: Further Insight into the Mechanism of Enzyme Action

    Article • Biochemistry, July 2008, American Chemical Society (ACS)

    Professor Claudia Sissi

  38. Effective DNA Inhibitors of Cathepsin G by In Vitro Selection

    Article • International Journal of Molecular Sciences, June 2008, MDPI AG

    Professor Claudia Sissi

  39. Tuning the Activity of Zn(II) Complexes in DNA Cleavage: Clues for Design of New Efficient Metallo-Hydrolases

    Article • Inorganic Chemistry, May 2008, American Chemical Society (ACS)

    Professor Claudia Sissi

  40. Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives

    Article • Bioorganic & Medicinal Chemistry, January 2008, Elsevier

    Professor Claudia Sissi, Professor Diego Dal Ben

  41. DNA Binding by a New Metallointercalator that Contains a Proflavine Group Bearing a Hanging Chelating Unit

    Article • Chemistry - A European Journal, December 2007, Wiley

    Antonio Bianchi, Professor Claudia Sissi

  42. Interactions of low-molecular-weight semi-synthetic sulfated heparins with human leukocyte elastase and human Cathepsin G

    Article • Biochemical Pharmacology, January 2006, Elsevier

    Professor Claudia Sissi

  43. Efficient Plasmid DNA Cleavage by a Mononuclear Copper(II) Complex

    Article • Inorganic Chemistry, March 2005, American Chemical Society (ACS)

    Professor Claudia Sissi

  44. Toward Efficient Zn(II)-Based Artificial Nucleases

    Article • Journal of the American Chemical Society, March 2004, American Chemical Society (ACS)

    Professor Claudia Sissi

  45. Antitumor AZA-anthrapyrazoles: biophysical and biochemical studies on 8- and 9-aza regioisomers

    Article • Biochemical Pharmacology, February 2004, Elsevier

    Professor Claudia Sissi

  46. Antitumor Potential of Aza-bioisosterism in Anthracenedione-based Drugs

    Article • Current Topics in Medicinal Chemistry, January 2004, Bentham Science Publishers

    Professor Claudia Sissi

  47. The Quinolone Family: From Antibacterial to Anticancer Agents

    Article • Current Medicinal Chemistry - Anti-Cancer Agents, November 2003, Bentham Science Publishers

    Professor Claudia Sissi

  48. Sequence-specific interactions of drugs interfering with the topoisomerase–DNA cleavage complex

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, July 2002, Elsevier

    Professor Claudia Sissi

  49. Effects of Calcium Ions on the Interactions between Antithrombin and Factor Xa Mediated by Variously Sulfated, Semisynthetic Low-Molecular-Weight Heparins

    Article • Seminars in Thrombosis and Hemostasis, January 2002, Thieme Publishing Group

    Professor Claudia Sissi

  50. Ciprofloxacin affects conformational equilibria of DNA gyrase A in the presence of magnesium ions

    Article • Journal of Molecular Biology, August 2001, Elsevier

    Professor Claudia Sissi

  51. Dinuclear Zn2+ Complexes of Synthetic Heptapeptides as Artificial Nucleases

    Article • Journal of the American Chemical Society, March 2001, American Chemical Society (ACS)

    Professor Claudia Sissi

  52. Effects of Sulfation on Antithrombin-Thrombin/Factor Xa Interactions in Semisynthetic Low Molecular Weight Heparins

    Article • Seminars in Thrombosis and Hemostasis, January 2001, Thieme Publishing Group

    Professor Claudia Sissi

  53. A Novel 9-Aza-Anthrapyrazole Effective against Human Prostatic Carcinoma Xenografts

    Article • Oncology, January 2001, Karger Publishers

    Professor Claudia Sissi

  54. 6-Hydroxy Derivative as New Desfluoroquinolone (DFQ): Synthesis and DNA-Binding Study

    Article • Nucleosides Nucleotides & Nucleic Acids, August 2000, Taylor & Francis

    Professor Claudia Sissi

  55. DNA Phosphodiester Bond Hydrolysis Mediated by Cu(II) and Zn(II) Complexes of 1,3,5,-Triamino-cyclohexane Derivatives

    Article • Nucleosides Nucleotides & Nucleic Acids, August 2000, Taylor & Francis

    Professor Claudia Sissi

  56. Design and Synthesis of Modified Quinolones as Antitumoral Acridones

    Article • Journal of Medicinal Chemistry, May 1999, American Chemical Society (ACS)

    Professor Claudia Sissi, Prof Giuseppe Nocentini

  57. Further insight into the Zn2+-mediated binding of streptonigrin to DNA

    Article • Il Farmaco, November 1998, Elsevier

    Professor Claudia Sissi

  58. Mg 2+ -mediated binding of 6-Substituted quinolones to DNA: relevance to biological activity

    Article • Bioorganic & Medicinal Chemistry, September 1998, Elsevier

    Professor Claudia Sissi

  59. New Peptidyl-Anthraquinones: Synthesis and DNA Binding

    Article • Nucleosides and Nucleotides, September 1998, Taylor & Francis

    Professor Claudia Sissi

  60. Preferred interaction of d-peptidyl-anthraquinones with double-stranded B-DNA

    Article • International Journal of Biological Macromolecules, December 1997, Elsevier

    Professor Claudia Sissi

  61. Physicochemical properties, cytotoxic activity and topoisomerase ii inhibition of 2,3-diaza-anthracenediones

    Article • Biochemical Pharmacology, January 1997, Elsevier

    Professor Claudia Sissi

  62. Peptidyl Anthraquinones as Potential Antineoplastic Drugs:  Synthesis, DNA Binding, Redox Cycling, and Biological Activity

    Article • Journal of Medicinal Chemistry, January 1996, American Chemical Society (ACS)

    Professor Claudia Sissi

  63. Potent 6-Desfluoro-8-methylquinolones as New Lead Compounds in Antibacterial Chemotherapy

    Article • Journal of Medicinal Chemistry, January 1996, American Chemical Society (ACS)

    Professor Claudia Sissi

  64. Chromophore-Modified Antitumor Anthracenediones: Synthesis, DNA Binding, and Cytotoxic Activity of 1,4-Bis[(aminoalkyl)amino]benzo[g]phthalazine-5,10-diones

    Article • Journal of Medicinal Chemistry, February 1995, American Chemical Society (ACS)

    Professor Claudia Sissi