All Stories

  1. Design, Synthesis and Antiproliferative Evaluation of Glucose 6ʺ-OH Modified Open-Chain Analogues of Ipomoeassin F

    Article • October 2024, MDPI AG

    Wei Shi

  2. A common mechanism of Sec61 translocon inhibition by small molecules

    Article • Nature Chemical Biology, May 2023, Springer Science + Business Media

    Wei Shi

  3. A common mechanism of Sec61 translocon inhibition by small molecules

    Article • August 2022, Cold Spring Harbor Laboratory Press

    Wei Shi

  4. Synthesis, Biological Evaluation and Docking Studies of Ring-Opened Analogues of Ipomoeassin F

    Article • Molecules, July 2022, MDPI AG

    Wei Shi

  5. Co-translational biogenesis of lipid droplet integral membrane proteins

    Article • Journal of Cell Science, November 2021, The Company of Biologists

    Wei Shi

  6. Co-translational biogenesis of lipid droplet integral membrane proteins

    Article • August 2021, Cold Spring Harbor Laboratory Press

    Wei Shi

  7. An alternative pathway for membrane protein biogenesis at the endoplasmic reticulum

    Article • Communications Biology, July 2021, Springer Science + Business Media

    Dr Sarah O'Keefe, Wei Shi

  8. Ipomoeassin-F disrupts multiple aspects of secretory protein biogenesis

    Article • Scientific Reports, June 2021, Springer Science + Business Media

    Dr Sarah O'Keefe, Wei Shi

  9. A potentially new broad-spectrum antiviral: a SARS-CoV-2 in vitro study

    Article • Journal of Cell Science, January 2021, The Company of Biologists

    Dr Sarah O'Keefe, Wei Shi

  10. Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F

    Article • The Journal of Organic Chemistry, December 2020, American Chemical Society (ACS)

    Dr Sarah O'Keefe, Wei Shi

  11. Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor

    Article • November 2020, Cold Spring Harbor Laboratory Press

    Wei Shi

  12. Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle

    Article • PLoS Biology, September 2020, PLOS

    Wei Shi

  13. Design and Synthesis of Tetrazole- and Pyridine-Containing Itraconazole Analogs as Potent Angiogenesis Inhibitors

    Article • ACS Medicinal Chemistry Letters, April 2020, American Chemical Society (ACS)

    Wei Shi

  14. Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

    Article • Journal of the American Chemical Society, May 2019, American Chemical Society (ACS)

    Dr Sarah O'Keefe, Wei Shi

  15. Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

    Article • January 2019, American Chemical Society (ACS)

    Wei Shi

  16. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

    Article • ACS Central Science, December 2018, American Chemical Society (ACS)

    Wei Shi

  17. Novel Tetrazole-Containing Analogues of Itraconazole as Potent Antiangiogenic Agents with Reduced Cytochrome P450 3A4 Inhibition

    Article • Journal of Medicinal Chemistry, November 2018, American Chemical Society (ACS)

    Wei Shi

  18. Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP)

    Article • Antiviral Research, August 2018, Elsevier

    Wei Shi

  19. New insights into structure–activity relationship of ipomoeassin F from its bioisosteric 5-oxa/aza analogues

    Article • European Journal of Medicinal Chemistry, January 2018, Elsevier

    Wei Shi

  20. Design, synthesis and biological evaluation of fucose-truncated monosaccharide analogues of ipomoeassin F

    Article • Bioorganic & Medicinal Chemistry Letters, June 2017, Elsevier

    Wei Shi

  21. Synergistic Contribution of Tiglate and Cinnamate to Cytotoxicity of Ipomoeassin F

    Article • The Journal of Organic Chemistry, April 2017, American Chemical Society (ACS)

    Wei Shi

  22. Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis

    Article • ACS Chemical Biology, December 2016, American Chemical Society (ACS)

    Wei Shi

  23. Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of Itraconazole

    Article • Clinical Cancer Research, May 2016, American Association for Cancer Research (AACR)

    Wei Shi

  24. Revealing the Pharmacophore of Ipomoeassin F through Molecular Editing

    Article • Organic Letters, March 2016, American Chemical Society (ACS)

    Wei Shi

  25. Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells

    Article • Proceedings of the National Academy of Sciences, December 2015, Proceedings of the National Academy of Sciences

    Wei Shi

  26. Total Synthesis and Biological Evaluation of Ipomoeassin F and Its Unnatural 11R-Epimer

    Article • The Journal of Organic Chemistry, September 2015, American Chemical Society (ACS)

    Wei Shi

  27. Stereospecific Metabolism of Itraconazole by CYP3A4: Dioxolane Ring Scission of Azole Antifungals

    Article • Drug Metabolism and Disposition, November 2011, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Wei Shi

  28. Itraconazole Side Chain Analogues: Structure–Activity Relationship Studies for Inhibition of Endothelial Cell Proliferation, Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Glycosylation, and Hedgehog Signaling

    Article • Journal of Medicinal Chemistry, October 2011, American Chemical Society (ACS)

    Wei Shi

  29. Reprint of “Effect of carbohydrate amino group modifications on the cytotoxicity of glycosylated 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans” [Bioorg. Med. Chem. Lett. 21 (2011) 2591–2596]

    Article • Bioorganic & Medicinal Chemistry Letters, May 2011, Elsevier

    Wei Shi

  30. Structure–activity relationships in glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans as DNA binding and potential antitumor agents

    Article • Bioorganic & Medicinal Chemistry, March 2011, Elsevier

    Wei Shi

  31. Cytotoxicity and topoisomerase I/II inhibition of glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans

    Article • Bioorganic & Medicinal Chemistry, January 2011, Elsevier

    Wei Shi

  32. Impact of Absolute Stereochemistry on the Antiangiogenic and Antifungal Activities of Itraconazole

    Article • ACS Medicinal Chemistry Letters, April 2010, American Chemical Society (ACS)

    Wei Shi

  33. Determination of the absolute configurations of synthetic daunorubicin analogues using vibrational circular dichroism spectroscopy and density functional theory

    Article • Chirality, January 2010, Wiley

    Wei Shi

  34. Synthesis and antibacterial activity of aminosugar-functionalized intercalating agents

    Article • Carbohydrate Research, January 2010, Elsevier

    Wei Shi

  35. Synthesis and DNA-binding affinity studies of glycosylated intercalators designed as functional mimics of the anthracycline antibiotics

    Article • Organic & Biomolecular Chemistry, January 2009, Royal Society of Chemistry

    Wei Shi

  36. Synthesis of Daunorubicin Analogues Containing Truncated Aromatic Cores and Unnatural Monosaccharide Residues

    Article • The Journal of Organic Chemistry, March 2007, American Chemical Society (ACS)

    Wei Shi

  37. Chemical and chemoenzymatic synthesis of a trisaccharide fragment of Tsukamurella paurometabola lipoarabinomannan

    Article • Canadian Journal of Chemistry, April 2006, Canadian Science Publishing

    Wei Shi

  38. A Divergent Synthesis of Triyne Natural Products and Glycosylated Analogues Using a Carbenoid Rearrangement

    Article • Synthesis, January 2005, Thieme Publishing Group

    Wei Shi