Post-COVID-19 Syndrome vs. Consequences of Vaccination with Special Reference to Cardiovascular Conditions

What is it about?

Consequences of COVID-19 vaccination partly overlap with symptoms of post-COVID-19 syndrome. Putative mechanisms are also overlapping: endothelial damage and hypercoagulation, hypoxia, autoimmunity, inflammation, downregulation of angiotensin-converting enzyme 2. It can be reasonably assumed that effects of viral spike protein, observed in COVID-19, would to some extent appear also after administration of vaccines containing spike protein or inducing its synthesis. Vaccination with new vaccines entails known and unknown risks. Children, young adults and other people can mount their own immunity to SARS-CoV2. Admittedly, postvaccinal cardiovascular events are usually benign and self-limited. However, pressures for rapid approval of vaccines can result in the distribution of preparations with unstable quality, which depends on the manufacturing standards. There have been few reports from Russia about blood clotting-related, cardiovascular and other adverse effects after vaccinations. The number of undetected cases is unknown. Reports on side effects of some renowned vaccines do not imply higher risks but indicate that they are better studied. In conclusion, healthcare providers should be vigilant for side effects of COVID-19 vaccinations; further research especially of long-term risks is needed.

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