What is it about?
Twenty eight male Wistar rats were divided into four groups: controls, zymosan-injected, vitamin E injected, and pair-fed . Rats were fed Osmolite-HN, and were sacrificed on day three. Phosphofructokinase activity was measured in EDL and soleus muscles using a fluorometric assay, and was found to be significantly lower in both the soleus and EDL muscles of trauma rats with peritonitis. Three days of intramuscular injections of vitamin E significantly (p<0.05) protected glycolytic activity, in fast-twitch but not in slowtwitch muscles.
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Why is it important?
This research demonstrates that in a state of malnutrition, during trauma or sepsis, intramuscular injections of an antioxidant such as vitamin E can protect the integrity of the glycolytic cycle in both fast and slow-twitch muscles.
Perspectives
Protecting the integrity of glycolysis during trauma and malnutrition is important as it helps patients regain muscle function quicker and therefore can help decrease the length of hospital stay.
David Bissonnette
Minnesota State Colleges and University System
Read the Original
This page is a summary of: The Effect of Intra-Muscular Injections of Alpha-tocopherol on the Activity of Phospho- Fructokinase in the Slow- and Fast-Twitch Skeletal Muscles of Metabolic Stress-Induced and Malnourished Rats, GSTF Journal of BioSciences, December 2012, Global Science & Technology Forum,
DOI: 10.5176/2251-3140_2.1.17.
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