What is it about?
Aflatoxin B1 (AFB1), a pre-carcinogenic and toxics compound which contaminate foodstuffs and edible tissues, are associated with oxidative stress and hepatotoxicity. This investigation aimed at assessing the counteractive role for ethanol (EWP), petroleum ether (PWP) and n-hexane (HWP) white pepper extracts for oxidative stress and hepatotoxicity induced by AFB1 in a rat model. Concentrated white pepper extracts (WPEs) estimated for total phenolic, total flavonoids, antioxidant, and antifungal activities. Otherwise, the fatty acids composition of white pepper was analyzed. Forty-eight male albino rats divided into eight groups which were treated to evaluate the WPEs biological effect at the AFB1 presence or absence, negative and positive AFB1 groups are including. The results elucidated the WPEs suppression, either raising aminotransferases enzymes (alanine and aspartate), alkaline phosphatase, while it reduced the total protein. WPEs combat the negative impact of AFB1 on kidney functions and alleviated AFB1 mediated oxidative stress either in plasma or liver. Also, it relieved the AFB1 mediated lipid disturbance and hemoglobin reduction and exhibited antioxidant and antifungal activities. Moreover, the extracts gave a counteractive role for oxidative stress and hepatotoxicity induced by AFB1.
Featured Image
Photo by Sonja Punz on Unsplash
Why is it important?
The results of the current investigation indicated to the potency of white pepper extracts as an antioxidant and antifungal agent. Among several extraction systems; the most promising effect was accomplished by the petroleum ether extract of white pepper, either for its bioactive components contents or its antifungal potency. The counteractive role of white pepper extracts for oxidative stress and hepatotoxicity induced by aflatoxin B1 in rats was demonstrated. These results directing to recommend implementing WPEs in safe foodstuffs production, mycotoxin health hazard avoidance in food products, besides the possibility to extend food shelf-life.
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had better collaborations. This article also leads to reducing Aflatoxins toxicity which contacting food and food products and ultimately to greater involvement in excellent research as defenses against mycotoxin.
Dr Ahmed Noah Badr
National Research Centre, Egypt
Read the Original
This page is a summary of: Counteractive Role of White Pepper Extracts for Oxidative Stress and Hepatotoxicity Induced by Aflatoxin B1 in Rats, International Journal of Pharmacology, February 2019, Science Alert,
DOI: 10.3923/ijp.2019.177.188.
You can read the full text:
Resources
Contributors
The following have contributed to this page
