What is it about?
Raw Azdirachta indica seed oil is gradually adopted by local farmers for protecting stored grains and legumes against insect pests, but with some reservations on its safety. The study investigated the safety A. indica on mammalian objects using haematological and antioxidant indices. A. indica seed was obtained from the trees in Utu Ikot Ukpong, Essien Udim Local Government Area, Nigeria. The Albino rats were obtained from the Animal House of Biochemistry Department of the University of Calabar, Nigeria. The animals were treated with varied A. indica seed oil at varied concentrations, periods of exposure and age. Haematological analyses revealed that models of packed cell volume (PCV), red blood cell (RBC), white cell count (WCC) and hemoglobin content (Hb) were not significant. Catalase (CAT), Biomarkers of toxicity (superoxide dismutase (SOD), and glutathione (GSH) were also not significant (p>0.05)). Linearity coefficients of the models however appeared to be significant (R2≤0.8000). The mathematical and pictorial models showed slight influence of the test substance on the parameters. The investigation revealed that A. indica seed oil showed no adverse effect on the haematological and antioxidant profile of the animal models at the level of administration, the slight statistical significance could be attributed to other experimental values. A. indica oil seems to be safe on mammalian subjects. More work is recommended on the topic using higher levels of the plant materials at a longer period of exposure
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Why is it important?
Azadirachta indica seed oil is used for stored grin protection. This research has ascertained that the oil is safe for use by humans and does not induce toxicity.
Perspectives
Use Azadirachta indica seed oil for the protection of stored grains against insect infestation
Professor Philippa C OJIMELUKWE
Michael Okpara University of Agriculture Umudike, Abia state, Nigeria
Read the Original
This page is a summary of: Evaluation of safety of Azdirachta indica seed oil on Albino rat through haematological and some antioxidants by the rotatable central composite design (RCCD) of the response surface methodology (RSM), International Journal of Environment Agriculture and Biotechnology, January 2018, AI Publications,
DOI: 10.22161/ijeab/3.6.11.
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