Comparison of viral vectors after intravitreal gene transfer to mouse eye

What is it about?

The eye is a valuable target for gene therapy applications. We studied the transduction efficiency, safety and biodistribution of adeno-associated virus, adenovirus, baculovirus and lentivirus vectors encoding GFP at multiple time points after intravitreal gene delivery.

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Why is it important?

We show that intravitreal gene transfer is safe and feasible with AAV, AdV and lentivirus vectors. The cells that were transduced, the time of the transgene expression and the evoked immune responses varied between viral vectors. The results are important to find suitable viral vector for different intravitreal gene therapy applications.