What is it about?
Brain injury around the time of birth causes lasting damage that prevents typical functioning for the whole life. This review highlights, that it isnt just that the brain is damaged, but that there are ongoing active changes in the molecules, pathways and cellular function that are viable targets for improving brain health and functions. We collect together all the clinical data and pre-clinical work that shows tertiary phase treatments can be effective.
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Photo by Ian Schneider on Unsplash
Why is it important?
This review calls for research into perinatal brain injuries to study in detail the events in the tertiary phase, to increase our understanding and turn the idea of clinically implementable effective tertiary phase treatments into a reality.
Perspectives
The idea of the tertiary phase of injury shows that ignoring the dogma that long after injury, the brain is static, unchanging, and unchangeable can lead to a new hope for therapies. We now see that the brain has persisting active events that we modify to improve brain health and decrease the negative impacts of perinatal brain injury.
Lab head - Perinatal Brain Injury Lab Bobbi Fleiss
RMIT University
Read the Original
This page is a summary of: Mechanisms of tertiary neurodegeneration after neonatal hypoxic-ischemic brain damage, Pediatric Medicine, August 2022, AME Publishing Company,
DOI: 10.21037/pm-20-104.
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