The effects of graded levels of calorie restriction: VII. Topological rearrangement of hypothalamic aging networks

What is it about?

A large number of interacting genes, forming an interaction network, alter their transcription in response to ageing and calorie restriction (CR). However, understanding the complex interactions between genes is a challenge that cannot be addressed by looking at gene expression alone. Network analyses of interactions between genes could further elaborate the complex mechanisms underlying both ageing and CR. Here, we investigated if CR could prevent the age-associated loss in network connectivity.

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Why is it important?

Overall our results suggested that calorie restriction induced changes in centrality of biological relevant genes that play an important role in preventing the age-associated loss of network integrity irrespective of their gene expression levels.