Amino Acids Diets as Model for Investigating Cancer Induced by Acrylamide in Food

What is it about?

Starvation could be the cheapest solution for cancer treatment. Alternatively, controlled amino acids diets could be another solution. Starving the body from certain amino acids as well as changing the amount of some used amino acids con-trolled diet is the main idea of this study. In this study, acrylamide was used to induce cancer in the rats. Acrylamide is a cancer causative agent. We utilize it through a diet containing potato. To evaluate the effect of such change in the cancer cells induced by acrylamide in rats, five diets different in their amino acids constituents were designed. Rats were feed on the different amino acids diets to investigate their effect on the cancer induced by the acrylamide. Biochemical analysis for the liver functions represented by GOT, GPT and ALP, assays as well as the amount of the produced billirubin and cholesterol were performed. Additionally the weight and the histo-pathological changes in each of the liver, lung and kidney tissues were investigated. To evaluate the effect of the treatments on the molecular level P53 expression level as a cancer genetic marker were investigated. The results were subjected to logical and statistical analysis. Statistical analyses for the data using LSD were generated. The data obtained from this study prove that the amino acids controlled diets could incapsitate for some extend the development of the cancer cells. In this study, protection against the formation of the cancer is also reported. The main explanation is that such controlled diet might be able to reduce the growth rate of the cancer cells or give suitable time to the cell self-killing mechanism to be complement with the cancer cells replication rate and growing time. Depleting seven amino acids from the diet show the best result (group 7). The study prove that vegetarian, those how fasting or starving are safer and can resist cancer. However they are more susceptible to exogenous source of toxins such as the acrylamide than those who include amino acids in their diets. Controlled amino acids diets show different results according to the amino acids composition. This study recommended use of controlled amino acids to save our health. And more study for the role of the controlled amino acids diets either in cancer protection, prevention or treatment as well as which amino acid(s) should be depleted from which cancer cells should be conducted.

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Why is it important?

This study investigates the role of the amino acids different composition in the rats treated by acrylamide. The acrylamide was selected while it existed during the eating of the potato frits. The experimental design is based on our aim to investigate if vegetarian or those how starve or fast from protein containing food are susceptible to the side effect of the acrylamide based on the fact that they receive lesser amino acids. Additionally, the study investigates the role of different amino acids in the protection against the acrylamide side effect. For that each of the control and the treatment receive no amino acids and represent those who keep amino acids away from their diets but not receive/ or receive acrylamide in their food. To prove/or disprove the role of the controlled diets in the protection, treatment of the toxic (as well as the carcinogenic) side effect of the acrylamide five different diets contain different amino acids were used.