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Indirect immunofluorescence assay (IFA) patterns are useful in the interpretation of IFA on HEp-2 cells (HEp-2 IFA) for the screening of autoantibodies. The International Consensus on Antinuclear Antibody Patterns (ICAP) (www.ANApatterns.org) has defined 28 anti-cell (AC) patterns with detailed morphological characterization, representative images and immunological/clinical correlates. The present paper presents AC-29, the latest ICAP approved pattern, which is strongly associated with scleroderma-specific anti-topoisomerase I antibodies.

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This page is a summary of: International consensus on antinuclear antibody patterns: definition of the AC-29 pattern associated with antibodies to DNA topoisomerase I, Clinical Chemistry and Laboratory Medicine (CCLM), May 2018, De Gruyter,
DOI: 10.1515/cclm-2018-0188.
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