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  1. Establishment of international autoantibody reference standards for the detection of autoantibodies directed against PML bodies, GW bodies, and NuMA protein

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), August 2020, De Gruyter

    Edward K. L. Chan

  2. Ribavirin induces widespread accumulation of IMP dehydrogenase into rods/rings structures in multiple major mouse organs

    Article • Antiviral Research, February 2019, Elsevier

    Edward K. L. Chan

  3. Emerging microRNAs in cancer diagnosis, progression, and immune surveillance

    Article • Cancer Letters, December 2018, Elsevier

    Edward K. L. Chan

  4. Immune Response-Dependent Assembly of IMP Dehydrogenase Filaments

    Article • Frontiers in Immunology, November 2018, Frontiers

    Edward K. L. Chan

  5. Enoxacin and bis-enoxacin stimulate 4T1 murine breast cancer cells to release extracellular vesicles that inhibit osteoclastogenesis

    Article • Scientific Reports, November 2018, Springer Science + Business Media

    Edward K. L. Chan

  6. CIP2A immunosensor comprised of vertically-aligned carbon nanotube interdigitated electrodes towards point-of-care oral cancer screening

    Article • Biosensors and Bioelectronics, October 2018, Elsevier

    Edward K. L. Chan

  7. Clarification Needed Regarding Anti-Topoisomerase I as a Biomarker for Non-Small Cell Lung Cancer

    Article • The Annals of Thoracic Surgery, September 2018, Elsevier

    Edward K. L. Chan

  8. Prescription medication use and antinuclear antibodies in the United States, 1999–2004

    Article • Journal of Autoimmunity, August 2018, Elsevier

    Edward K. L. Chan

  9. International consensus on antinuclear antibody patterns: definition of the AC-29 pattern associated with antibodies to DNA topoisomerase I

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), May 2018, De Gruyter

    Edward K. L. Chan

  10. International Consensus on Antinuclear Antibody Patterns: defining negative results and reporting unidentified patterns

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), April 2018, De Gruyter

    Manfred Herold, Edward K. L. Chan

  11. CD70 as a target for chimeric antigen receptor T cells in head and neck squamous cell carcinoma

    Article • Oral Oncology, March 2018, Elsevier

    Edward K. L. Chan

  12. Reference standards for the detection of anti-mitochondrial and anti-rods/rings autoantibodies

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), February 2018, De Gruyter

    Edward K. L. Chan

  13. Antinuclear antibodies and mortality in the National Health and Nutrition Examination Survey (1999-2004)

    Article • PLoS ONE, October 2017, PLOS

    Edward K. L. Chan

  14. Aneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms

    Article • International Journal of Molecular Sciences, April 2017, MDPI AG

    Edward K. L. Chan

  15. Differential capacity of therapeutic drugs to induce Rods/Rings structures in vitro and in vivo and generation of anti-Rods/Rings autoantibodies

    Article • Clinical Immunology, December 2016, Elsevier

    Edward K. L. Chan

  16. MicroRNA-375 as a biomarker for malignant transformation in oral lesions

    Article • Oral Surgery Oral Medicine Oral Pathology and Oral Radiology, December 2016, Elsevier

    Edward K. L. Chan

  17. Anti-rods/rings autoantibody seropositivity does not affect response to telaprevir treatment for chronic hepatitis C infection

    Article • Autoimmunity Highlights, November 2016, Springer Science + Business Media

    Edward K. L. Chan

  18. Loukoumasomes Are Distinct Subcellular Structures from Rods and Rings and Are Structurally Associated with MAP2 and the Nuclear Envelope in Retinal Cells

    Article • PLoS ONE, October 2016, PLOS

    Edward K. L. Chan

  19. Biomarkers and Pathogenic Mechanisms in Autoimmunity

    Article • Immunologic Research, September 2016, Springer Science + Business Media

    Edward K. L. Chan

  20. Dr Eng M. Tan: a tribute to an enduring legacy in autoimmunity

    Article • Lupus, August 2016, SAGE Publications

    Edward K. L. Chan

  21. Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice

    Article • July 2016, Springer Science + Business Media

    Edward K. L. Chan

  22. ‘Rod and ring’ formation from IMP dehydrogenase is regulated through the one-carbon metabolic pathway

    Article • Journal of Cell Science, June 2016, The Company of Biologists

    Edward K. L. Chan

  23. A re-evaluation of anti-NA-14 antibodies in patients with primary Sjögren’s syndrome: Significant role of interferon-γ in the production of autoantibodies against NA-14

    Article • Autoimmunity, June 2016, Taylor & Francis

    Edward K. L. Chan

  24. I have been working with the ICAP group to reach a consensus in the interpretation of ANA patterns.

    Article • Lupus, May 2016, SAGE Publications

    IGNACIO GARCIA-DE LA TORRE, Edward K. L. Chan

  25. From autoantibody research to standardized diagnostic assays in the management of human diseases – report of the 12th Dresden Symposium on Autoantibodies

    Article • Lupus, May 2016, SAGE Publications

    Edward K. L. Chan

  26. Single-cell antibody nanowells: a novel technology in detecting anti-SSA/Ro60- and anti-SSB/La autoantibody-producing cells in peripheral blood of rheumatic disease patients

    Article • May 2016, Springer Science + Business Media

    Edward K. L. Chan

  27. Associations Between Selected Xenobiotics and Antinuclear Antibodies in the National Health and Nutrition Examination Survey, 1999–2004

    Article • Environmental Health Perspectives, April 2016, Environmental Health Perspectives

    Edward K. L. Chan

  28. International consensus on ANA patterns (ICAP): the bumpy road towards a consensus on reporting ANA results

    Article • Autoimmunity Highlights, January 2016, Springer Science + Business Media

    Edward K. L. Chan

  29. Anti-rods/rings autoantibody generation in hepatitis C patients during interferon-α/ribavirin therapy

    Article • World Journal of Gastroenterology, January 2016, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Edward K. L. Chan

  30. A Comprehensive Overview on Myositis-Specific Antibodies: New and Old Biomarkers in Idiopathic Inflammatory Myopathy

    Article • Clinical Reviews in Allergy & Immunology, September 2015, Springer Science + Business Media

    Edward K. L. Chan

  31. Report of the First International Consensus on Standardized Nomenclature of Antinuclear Antibody HEp-2 Cell Patterns 2014–2015

    Article • Frontiers in Immunology, August 2015, Frontiers

    Edward K. L. Chan

  32. Assembly of IMPDH2-Based, CTPS-Based, and Mixed Rod/Ring Structures Is Dependent on Cell Type and Conditions of Induction

    Article • Journal of Genetics and Genomics, June 2015, Elsevier

    Edward K. L. Chan

  33. The Uses and Misuses of Multiplex Autoantibody Assays in Systemic Autoimmune Rheumatic Diseases

    Article • Frontiers in Immunology, April 2015, Frontiers

    Edward K. L. Chan

  34. Interleukin 1�-Responsive MicroRNA-146a Is Critical for the Cytokine-Induced Tolerance and Cross-Tolerance to Toll-Like Receptor Ligands

    Article • Journal of Innate Immunity, April 2015, Karger Publishers

    Edward K. L. Chan

  35. Our Journey from the Study of Human Autoantibodies to the microRNA World

    Article • Frontiers in Immunology, March 2015, Frontiers

    Edward K. L. Chan

  36. Anti-Rods/Rings: A Human Model of Drug-Induced Autoantibody Generation

    Article • Frontiers in Immunology, February 2015, Frontiers

    Edward K. L. Chan

  37. miR-494 represses HOXA10 expression and inhibits cell proliferation in oral cancer

    Article • Oral Oncology, February 2015, Elsevier

    Edward K. L. Chan

  38. CIP2A regulates cancer metabolism and CREB phosphorylation in non-small cell lung cancer

    Article • Molecular BioSystems, January 2015, Royal Society of Chemistry

    Edward K. L. Chan

  39. Microinjection of specific anti-IMPDH2 antibodies induces disassembly of cytoplasmic rods/rings that are primarily stationary and stable structures

    Article • Cell & Bioscience, January 2015, Springer Science + Business Media

    Edward K. L. Chan

  40. Reproductive and Hormonal Risk Factors for Antinuclear Antibodies (ANA) in a Representative Sample of U.S. Women

    Article • Cancer Epidemiology Biomarkers & Prevention, August 2014, American Association for Cancer Research (AACR)

    Edward K. L. Chan

  41. Autoantibodies to the Rpp25 Component of the Th/To Complex are the Most Common Antibodies in Patients with Systemic Sclerosis without Antibodies Detectable by Widely Available Commercial Tests

    Article • The Journal of Rheumatology, June 2014, The Journal of Rheumatology

    Edward K. L. Chan

  42. Temporal evolution of human autoantibody response to cytoplasmic rods and rings structure during anti-HCV therapy with ribavirin and interferon-α

    Article • Immunologic Research, April 2014, Springer Science + Business Media

    Edward K. L. Chan

  43. Glutamine deprivation initiates reversible assembly of mammalian rods and rings

    Article • Cellular and Molecular Life Sciences, January 2014, Springer Science + Business Media

    Edward K. L. Chan

  44. Elevated signal transducers and activators of transcription 1 correlates with increased C-C motif chemokine ligand 2 and C-X-C motif chemokine 10 levels in peripheral blood of patients with systemic lupus erythematosus

    Article • Arthritis Research & Therapy, January 2014, Springer Science + Business Media

    Edward K. L. Chan

  45. Molecular Cell Biology and Immunobiology of Mammalian Rod/Ring Structures

    Article • January 2014, Elsevier

    Edward K. L. Chan

  46. Reduced levels of CCL2 and CXCL10 in systemic lupus erythematosus patients under treatment with prednisone, mycophenolate mofetil, or hydroxychloroquine, except in a high STAT1 subset

    Article • Arthritis Research & Therapy, January 2014, Springer Science + Business Media

    Edward K. L. Chan

  47. miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3ζ

    Article • Molecular Cancer, January 2014, Springer Science + Business Media

    Edward K. L. Chan

  48. Positive Correlation of STAT1 and miR-146a with Anemia in Patients with Systemic Lupus Erythematosus

    Article • Journal of Clinical Immunology, December 2013, Springer Science + Business Media

    Edward K. L. Chan

  49. International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies

    Article • Annals of the Rheumatic Diseases, October 2013, BMJ

    Edward K. L. Chan

  50. Antinuclear Antibody Test: When to Order?

    Article • The American Journal of Medicine, October 2013, Elsevier

    Edward K. L. Chan

  51. Tumor suppressor miR-375 regulates MYC expression via repression of CIP2A coding sequence through multiple miRNA–mRNA interactions

    Article • Molecular Biology of the Cell, June 2013, American Society for Cell Biology (ASCB)

    Edward K. L. Chan

  52. Regulation of TLR2-Mediated Tolerance and Cross-Tolerance through IRAK4 Modulation by miR-132 and miR-212

    Article • The Journal of Immunology, December 2012, The American Association of Immunologists

    Edward K. L. Chan

  53. MicroRNA-146a in autoimmunity and innate immune responses

    Article • Annals of the Rheumatic Diseases, December 2012, BMJ

    Edward K. L. Chan

  54. MicroRNAs and autoimmunity

    Article • Current Opinion in Immunology, December 2012, Elsevier

    Edward K. L. Chan

  55. An SNP in the Trinucleotide Repeat Region of the TNRC6A Gene Maps to a Major TNGW1 Autoepitope in Patients with Autoantibodies to GW182

    Article • November 2012, Springer Science + Business Media

    Edward K. L. Chan

  56. Autoantibodies to Argonaute 2 (Su Antigen)

    Article • November 2012, Springer Science + Business Media

    Edward K. L. Chan

  57. Function of GW182 and GW Bodies in siRNA and miRNA Pathways

    Article • November 2012, Springer Science + Business Media

    Edward K. L. Chan

  58. Introduction: The GW Body Story as an Example of Autoantibodies with Significant Impacts to Molecular Cell Biology

    Article • November 2012, Springer Science + Business Media

    Edward K. L. Chan

  59. Reflections on Ten Years of History of, and Future Prospects for, GW182 and GW/P Body Research

    Article • November 2012, Springer Science + Business Media

    Edward K. L. Chan

  60. Relationship of Other Cytoplasmic Ribonucleoprotein Bodies (cRNPB) to GW/P Bodies

    Article • November 2012, Springer Science + Business Media

    Edward K. L. Chan

  61. The Discovery of GW Bodies

    Article • November 2012, Springer Science + Business Media

    Edward K. L. Chan

  62. Differential Reactivity to IMPDH2 by Anti-rods/rings Autoantibodies and Unresponsiveness to Pegylated Interferon-alpha/Ribavirin Therapy in US and Italian HCV Patients

    Article • Journal of Clinical Immunology, October 2012, Springer Science + Business Media

    Edward K. L. Chan

  63. Defining a new role of GW182 in maintaining miRNA stability

    Article • EMBO Reports, October 2012, EMBO

    Edward K. L. Chan

  64. Longitudinal Study of a Human Drug-Induced Model of Autoantibody to Cytoplasmic Rods/Rings following HCV Therapy with Ribavirin and Interferon-α

    Article • PLoS ONE, September 2012, PLOS

    Edward K. L. Chan

  65. Keratinization-associated miR-7 and miR-21 Regulate Tumor Suppressor Reversion-inducing Cysteine-rich Protein with Kazal Motifs (RECK) in Oral Cancer

    Article • Journal of Biological Chemistry, July 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Edward K. L. Chan

  66. Prevalence and sociodemographic correlates of antinuclear antibodies in the United States

    Article • Arthritis & Rheumatism, June 2012, Wiley

    Edward K. L. Chan

  67. A new immunoprecipitation-real time quantitative PCR assay for anti-Th/To and anti-U3RNP antibody detection in systemic sclerosis

    Article • Arthritis Research & Therapy, January 2012, Springer Science + Business Media

    Edward K. L. Chan

  68. Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis

    Article • Arthritis Research & Therapy, January 2012, Springer Science + Business Media

    Edward K. L. Chan

  69. Autoantibodies to transcription intermediary factor (TIF)1β associated with dermatomyositis

    Article • Arthritis Research & Therapy, January 2012, Springer Science + Business Media

    Edward K. L. Chan

  70. Role of environmental factors in autoantibody production - importance of a detailed analysis in a small cohort

    Article • Arthritis Research & Therapy, January 2012, Springer Science + Business Media

    Edward K. L. Chan

  71. Induction of Cytoplasmic Rods and Rings Structures by Inhibition of the CTP and GTP Synthetic Pathway in Mammalian Cells

    Article • PLoS ONE, December 2011, PLOS

    Edward K. L. Chan

  72. High resolution of microRNA signatures in human whole saliva

    Article • Archives of Oral Biology, December 2011, Elsevier

    Edward K. L. Chan

  73. Common Pathways of Autoimmune Inflammatory Myopathies and Genetic Neuromuscular Disorders

    Article • Clinical Reviews in Allergy & Immunology, November 2011, Springer Science + Business Media

    Edward K. L. Chan

  74. Coexistence of anti-RNA polymerase III and anti-U1RNP antibodies in patients with systemic lupus erythematosus: two cases without features of scleroderma

    Article • Lupus, October 2011, SAGE Publications

    Edward K. L. Chan

  75. A secretagogue-small interfering RNA conjugate confers resistance to cytotoxicity in a cell model of Sjögren's syndrome

    Article • Arthritis & Rheumatism, September 2011, Wiley

    Edward K. L. Chan

  76. MicroRNA in TLR signaling and endotoxin tolerance

    Article • Cellular and Molecular Immunology, August 2011, Springer Science + Business Media

    Edward K. L. Chan

  77. Autoantibodies to survival of motor neuron complex in patients with polymyositis: Immunoprecipitation of D, E, F, and G proteins without other components of small nuclear ribonucleoproteins

    Article • Arthritis & Rheumatism, June 2011, Wiley

    Edward K. L. Chan

  78. Altered miR-146a expression in Sjögren's syndrome and its functional role in innate immunity

    Article • European Journal of Immunology, May 2011, Wiley

    Edward K. L. Chan

  79. MicroRNAs in rheumatoid arthritis

    Article • FEBS Letters, May 2011, Wiley

    Edward K. L. Chan

  80. Gender and ethnicity differences in the prevalence of scleroderma-related autoantibodies

    Article • Clinical Rheumatology, April 2011, Springer Science + Business Media

    Edward K. L. Chan

  81. Lupus T cells switched on by DNA hypomethylation via microRNA?

    Article • Arthritis & Rheumatism, April 2011, Wiley

    Edward K. L. Chan

  82. Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmon

    Article • Fish & Shellfish Immunology, April 2011, Elsevier

    Edward K. L. Chan

  83. Polymicrobial Infection with Periodontal Pathogens Specifically Enhances MicroRNA miR-146a in ApoE−/−Mice during Experimental Periodontal Disease

    Article • Infection and Immunity, January 2011, ASM Journals

    Edward K. L. Chan

  84. Cytoplasmic rods and rings autoantibodies developed during pegylated interferon and ribavirin therapy in patients with chronic hepatitis C

    Article • Antiviral Therapy, January 2011, International Medical Press

    Edward K. L. Chan

  85. Atypical clinical presentation of a subset of patients with anti-RNA polymerase III - non-scleroderma cases associated with dominant RNA polymerase i reactivity and nucleolar staining

    Article • Arthritis Research & Therapy, January 2011, Springer Science + Business Media

    Edward K. L. Chan

  86. Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study

    Article • Arthritis Research & Therapy, January 2011, Springer Science + Business Media

    Edward K. L. Chan

  87. Mapping of Ago2–GW182 Functional Interactions

    Article • January 2011, Springer Science + Business Media

    Edward K. L. Chan

  88. MicroRNAs in systemic rheumatic diseases

    Article • Arthritis Research & Therapy, January 2011, Springer Science + Business Media

    Edward K. L. Chan

  89. Mechanistic Role of MicroRNA-146a in Endotoxin-Induced Differential Cross-Regulation of TLR Signaling

    Article • The Journal of Immunology, December 2010, The American Association of Immunologists

    Edward K. L. Chan

  90. Divergent GW182 functional domains in the regulation of translational silencing

    Article • Nucleic Acids Research, December 2010, Oxford University Press (OUP)

    Edward K. L. Chan

  91. CIP2A expression and localization in oral carcinoma and dysplasia

    Article • Cancer Biology & Therapy, October 2010, Taylor & Francis

    Edward K. L. Chan

  92. Anti-argonaute2 (Ago2/Su) and -Ro antibodies identified by immunoprecipitation in primary anti-phospholipid syndrome (PAPS)

    Article • Autoimmunity, August 2010, Taylor & Francis

    Edward K. L. Chan

  93. Anti-Th/To Are Common Antinucleolar Autoantibodies in Italian Patients with Scleroderma

    Article • The Journal of Rheumatology, August 2010, The Journal of Rheumatology

    Edward K. L. Chan

  94. Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells

    Article • Genes Chromosomes and Cancer, March 2010, Wiley

    Edward K. L. Chan

  95. Life stress, negative mood states, and antibodies to heat shock protein 70 in endometrial cancer

    Article • Brain Behavior and Immunity, February 2010, Elsevier

    Edward K. L. Chan

  96. High prevalence of autoantibodies to RNA helicase A in Mexican patients with systemic lupus erythematosus

    Article • Arthritis Research & Therapy, January 2010, Springer Science + Business Media

    Edward K. L. Chan

  97. Formation of GW/P bodies as marker for microRNA-mediated regulation of innate immune signaling in THP-1 cells

    Article • Immunology and Cell Biology, November 2009, Wiley

    Edward K. L. Chan

  98. Citrulline Dependence of Anti-Cyclic Citrullinated Peptide Antibodies in Systemic Lupus Erythematosus as a Marker of Deforming/Erosive Arthritis

    Article • The Journal of Rheumatology, November 2009, The Journal of Rheumatology

    Edward K. L. Chan

  99. miR-146a Is Critical for Endotoxin-induced Tolerance

    Article • Journal of Biological Chemistry, October 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Edward K. L. Chan

  100. Identification of Enoxacin as an Inhibitor of Osteoclast Formation and Bone Resorption by Structure-Based Virtual Screening

    Article • Journal of Medicinal Chemistry, August 2009, American Chemical Society (ACS)

    Edward K. L. Chan

  101. Congenital Heart Block Not Associated with Anti-Ro/La Antibodies: Comparison with Anti-Ro/La-positive Cases

    Article • The Journal of Rheumatology, June 2009, The Journal of Rheumatology

    Edward K. L. Chan

  102. MicroRNA in autoimmunity and autoimmune diseases

    Article • Journal of Autoimmunity, May 2009, Elsevier

    Edward K. L. Chan

  103. Optimization of immunoprecipitation–western blot analysis in detecting GW182-associated components of GW/P bodies

    Article • Nature Protocols, April 2009, Springer Science + Business Media

    Edward K. L. Chan

  104. Contrast in aberrant microRNA expression in systemic lupus erythematosus and rheumatoid arthritis: Is microRNA-146 all we need?

    Article • Arthritis & Rheumatism, April 2009, Wiley

    Edward K. L. Chan

  105. The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing

    Article • RNA, March 2009, Cold Spring Harbor Laboratory Press

    Edward K. L. Chan

  106. Clinical interpretation of antinuclear antibody tests in systemic rheumatic diseases

    Article • Modern Rheumatology, March 2009, Taylor & Francis

    Edward K. L. Chan

  107. Antibody Reactivity to α-Enolase in Mothers of Children with Congenital Heart Block

    Article • The Journal of Rheumatology, February 2009, The Journal of Rheumatology

    Edward K. L. Chan

  108. Co-clustering of Golgi complex and other cytoplasmic organelles to crescentic region of half-moon nuclei during apoptosis

    Article • Cell Biology International, February 2009, Wiley

    Edward K. L. Chan

  109. Reduced IgG anti-small nuclear ribonucleoprotein autoantibody production in systemic lupus erythematosus patients with positive IgM anti-cytomegalovirus antibodies

    Article • Arthritis Research & Therapy, January 2009, Springer Science + Business Media

    Edward K. L. Chan

  110. Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencing

    Article • Journal of Cell Science, December 2008, The Company of Biologists

    Edward K. L. Chan

  111. MicroRNAs and Their Emerging Roles in Immunology

    Article • Annals of the New York Academy of Sciences, November 2008, Wiley

    Edward K. L. Chan

  112. Inflammatory caspases are critical for enhanced cell death in the target tissue of Sjögren's syndrome before disease onset

    Article • Immunology and Cell Biology, October 2008, Wiley

    Edward K. L. Chan

  113. Vaccination-Induced Systemic Autoimmunity in Farmed Atlantic Salmon

    Article • The Journal of Immunology, September 2008, The American Association of Immunologists

    Edward K. L. Chan

  114. Differential Anti-Golgi Complex Autoantibody Production Following Murine Lactate Dehydrogenase-Elevating Virus Infection

    Article • Immunopharmacology and Immunotoxicology, January 2008, Taylor & Francis

    Edward K. L. Chan

  115. Patients with pulmonary tuberculosis are frequently positive for anti–cyclic citrullinated peptide antibodies, but their sera also react with unmodified arginine-containing peptide

    Article • Arthritis & Rheumatism, January 2008, Wiley

    Edward K. L. Chan

  116. Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients

    Article • Arthritis Research & Therapy, January 2008, Springer Science + Business Media

    Edward K. L. Chan

  117. Clinical and serological features of patients with autoantibodies to GW/P bodies

    Article • Clinical Immunology, December 2007, Elsevier

    Edward K. L. Chan

  118. Markers of mRNA stabilization and degradation, and RNAi within astrocytoma GW bodies

    Article • Journal of Neuroscience Research, December 2007, Wiley

    Edward K. L. Chan

  119. AutoAbSC.Org — Autoantibody Standardization Committee in 2006

    Article • Autoimmunity Reviews, September 2007, Elsevier

    Edward K. L. Chan

  120. Clinical implication of autoantibodies in patients with systemic rheumatic diseases

    Article • Expert Review of Clinical Immunology, September 2007, Taylor & Francis

    Edward K. L. Chan

  121. Small Interfering RNA-mediated Silencing Induces Target-dependent Assembly of GW/P Bodies

    Article • Molecular Biology of the Cell, September 2007, American Society for Cell Biology (ASCB)

    Edward K. L. Chan

  122. CIP2A Inhibits PP2A in Human Malignancies

    Article • Cell, July 2007, Elsevier

    Edward K. L. Chan

  123. The role of GW/P-bodies in RNA processing and silencing

    Article • Journal of Cell Science, March 2007, The Company of Biologists

    Edward K. L. Chan

  124. Pol I Transcription and Pre-rRNA Processing Are Coordinated in a Transcription-dependent Manner in Mammalian Cells

    Article • Molecular Biology of the Cell, February 2007, American Society for Cell Biology (ASCB)

    Edward K. L. Chan

  125. Antibody detection using tumor-associated antigen mini-array in immunodiagnosing human hepatocellular carcinoma

    Article • Journal of Hepatology, January 2007, Elsevier

    Edward K. L. Chan

  126. Autoantibodies to RNA helicase A: A new serologic marker of early lupus

    Article • Arthritis & Rheumatism, January 2007, Wiley

    Edward K. L. Chan

  127. GOLGI COMPLEX AND ENDOSOME ANTIBODIES

    Article • January 2007, Elsevier

    Edward K. L. Chan

  128. GW BODIES, P BODIES AND COMPONENTS OF THE miRNA PATHWAY

    Article • January 2007, Elsevier

    Edward K. L. Chan

  129. Detection of the argonaute protein Ago2 and microRNAs in the RNA induced silencing complex (RISC) using a monoclonal antibody

    Article • Journal of Immunological Methods, December 2006, Elsevier

    Edward K. L. Chan

  130. Formation of GW bodies is a consequence of microRNA genesis

    Article • EMBO Reports, August 2006, EMBO

    Edward K. L. Chan

  131. Molecular Dynamics Simulation of Thermal Cycling Test in Electronic Packaging

    Article • Journal of Electronic Packaging, March 2006, ASME International

    Edward K. L. Chan

  132. GW Bodies, MicroRNAs and the Cell Cycle

    Article • Cell Cycle, January 2006, Taylor & Francis

    Edward K. L. Chan

  133. Article • Arthritis Research & Therapy, January 2006, Springer Science + Business Media

    Edward K. L. Chan

  134. Article • Arthritis Research & Therapy, January 2006, Springer Science + Business Media

    Edward K. L. Chan

  135. Nucleolar staining cannot be used as a screening test for the scleroderma marker anti–RNA polymerase I/III antibodies

    Article • Arthritis & Rheumatism, January 2006, Wiley

    Edward K. L. Chan

  136. Unusually high frequency of autoantibodies to PL-7 associated with milder muscle disease in Japanese patients with polymyositis/dermatomyositis

    Article • Arthritis & Rheumatism, January 2006, Wiley

    Edward K. L. Chan

  137. Disruption of GW bodies impairs mammalian RNA interference

    Article • Nature Cell Biology, November 2005, Springer Science + Business Media

    Edward K. L. Chan

  138. Autoimmune response to anti-apoptotic protein survivin and its association with antibodies to p53 and c-myc in cancer detection

    Article • Cancer Detection and Prevention, January 2005, Elsevier

    Edward K. L. Chan

  139. Article • Arthritis Research & Therapy, January 2005, Springer Science + Business Media

    Edward K. L. Chan

  140. Maternal antibody responses to the 52-kd SSA/RO p200 peptide and the development of fetal conduction defects

    Article • Arthritis & Rheumatism, January 2005, Wiley

    Edward K. L. Chan

  141. Preferential humoral immune response in prostate cancer to cellular proteins p90 and p62 in a panel of tumor-associated antigens

    Article • The Prostate, January 2005, Wiley

    Edward K. L. Chan

  142. Unique and shared features of Golgi complex autoantigens

    Article • Autoimmunity Reviews, January 2005, Elsevier

    Edward K. L. Chan

  143. GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation

    Article • Journal of Cell Science, November 2004, The Company of Biologists

    Edward K. L. Chan

  144. Relationship of maternal autoimmune response to clinical manifestations in children with congenital complete heart block

    Article • Acta Paediatrica, June 2004, Wiley

    Edward K. L. Chan

  145. Autoantibodies to protein transport and messenger RNA processing pathways: endosomes, lysosomes, Golgi complex, proteasomes, assemblyosomes, exosomes, and GW bodies

    Article • Clinical Immunology, January 2004, Elsevier

    Edward K. L. Chan

  146. Article • Arthritis Research, January 2004, Springer Science + Business Media

    Edward K. L. Chan

  147. Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182

    Article • Journal of Molecular Medicine, December 2003, Springer Science + Business Media

    Edward K. L. Chan

  148. The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies

    Article • RNA, October 2003, Cold Spring Harbor Laboratory Press

    Edward K. L. Chan

  149. Does the cellular localization of antigens in or on apoptotic blebs influence the pathogenicity or benefit of cognate antibodies? Comment on the article by Dieudé et al

    Article • Arthritis & Rheumatism, July 2003, Wiley

    Edward K. L. Chan

  150. A Panel of Monoclonal Antibodies to Cytoplasmic GW Bodies and the mRNA Binding Protein GW182

    Article • Hybridoma and Hybridomics, April 2003, Mary Ann Liebert Inc

    Edward K. L. Chan

  151. Interaction with GM130 during HERG Ion Channel Trafficking

    Article • Journal of Biological Chemistry, September 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Edward K. L. Chan

  152. The La RNA-binding Protein Interacts with the Vault RNA and Is a Vault-associated Protein

    Article • Journal of Biological Chemistry, August 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Edward K. L. Chan

  153. Cardiac 5-HT4 Serotoninergic Receptors, 52kD SSA/Ro and Autoimmune-Associated Congenital Heart Block

    Article • Journal of Autoimmunity, August 2002, Elsevier

    Edward K. L. Chan

  154. Cloning and characterization of a novel 90 kDa ‘companion’ auto-antigen of p62 overexpressed in cancer

    Article • Oncogene, July 2002, Springer Science + Business Media

    Edward K. L. Chan

  155. A Phosphorylated Cytoplasmic Autoantigen, GW182, Associates with a Unique Population of Human mRNAs within Novel Cytoplasmic Speckles

    Article • Molecular Biology of the Cell, April 2002, American Society for Cell Biology (ASCB)

    Edward K. L. Chan

  156. Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera

    Article • Arthritis & Rheumatism, March 2002, Wiley

    Edward K. L. Chan

  157. Article • Journal of Clinical Immunology, January 2002, Springer Science + Business Media

    Edward K. L. Chan

  158. Article • Arthritis Research, January 2002, Springer Science + Business Media

    Edward K. L. Chan

  159. Leucine zipper domain of 52 kDa SS-A/Ro promotes protein dimer formation and inhibits in vitro transcription activity

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, December 2001, Elsevier

    Edward K. L. Chan

  160. The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment

    Article • Nature Cell Biology, November 2001, Springer Science + Business Media

    Edward K. L. Chan

  161. AU Binding Proteins Recruit the Exosome to Degrade ARE-Containing mRNAs

    Article • Cell, November 2001, Elsevier

    Edward K. L. Chan

  162. Transcription Activating Property of Autoantigen SG2NA and Modulating Effect of WD-40 Repeats

    Article • Experimental Cell Research, October 2001, Elsevier

    Edward K. L. Chan

  163. SS-56, a novel cellular target of autoantibody responses in Sjögren syndrome and systemic lupus erythematosus

    Article • Journal of Clinical Investigation, September 2001, American Society for Clinical Investigation

    Edward K. L. Chan

  164. Aberrant Expression of Fetal RNA-Binding Protein p62 in Liver Cancer and Liver Cirrhosis

    Article • American Journal Of Pathology, September 2001, Elsevier

    Edward K. L. Chan

  165. Interaction between 52 kDa SSA/Ro and deubiquitinating enzyme UnpEL: a clue to function

    Article • The International Journal of Biochemistry & Cell Biology, September 2001, Elsevier

    Edward K. L. Chan

  166. Identification and Characterization of a Family of Rab11-interacting Proteins

    Article • Journal of Biological Chemistry, August 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Edward K. L. Chan

  167. Autoimmune Responses to mRNA Binding Proteins p62 and Koc in Diverse Malignancies

    Article • Clinical Immunology, August 2001, Elsevier

    Edward K. L. Chan

  168. Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product

    Article • The Journal of Cell Biology, July 2001, Rockefeller University Press

    Edward K. L. Chan

  169. Membrane Trafficking Machinery Components Associated with the Mammalian Acrosome during Spermiogenesis

    Article • Experimental Cell Research, July 2001, Elsevier

    Joao Ramalho-Santos, Edward K. L. Chan

  170. De-novo humoral immune responses to cancer-associated autoantigens during transition from chronic liver disease to hepatocellular carcinoma

    Article • Clinical & Experimental Immunology, July 2001, Wiley

    Edward K. L. Chan

  171. Anti-SSA/Ro and Anti-SSB/La Autoantibodies Bind the Surface of Apoptotic Fetal Cardiocytes and Promote Secretion of TNF-α by Macrophages

    Article • The Journal of Immunology, November 2000, The American Association of Immunologists

    Edward K. L. Chan

  172. Vesicular Traffic and Golgi Apparatus Dynamics During Mammalian Spermatogenesis: Implications for Acrosome Architecture1

    Article • Biology of Reproduction, July 2000, Oxford University Press (OUP)

    Edward K. L. Chan

  173. Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions

    Article • Journal of Allergy and Clinical Immunology, June 2000, Elsevier

    Edward K. L. Chan

  174. Structure and Characterization of the Murine p80 Coilin Gene, Coil

    Article • Journal of Structural Biology, April 2000, Elsevier

    Edward K. L. Chan

  175. The Golgi Apparatus Segregates from the Lysosomal/Acrosomal Vesicle during Rhesus Spermiogenesis: Structural Alterations

    Article • Developmental Biology, March 2000, Elsevier

    Joao Ramalho-Santos, Gerald Schatten, Edward K. L. Chan

  176. Human Autoantibodies to a Novel Golgi Protein Golgin-67: High Similarity With Golgin-95/gm 130 Autoantigen

    Article • Journal of Autoimmunity, March 2000, Elsevier

    Edward K. L. Chan

  177. Identification and Characterization of a Novel Golgi Protein, Golgin-67

    Article • Journal of Biological Chemistry, February 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Edward K. L. Chan

  178. Defining a novel 75-kDa phosphoprotein associated with SS-A/Ro and identification of distinct human autoantibodies

    Article • Journal of Clinical Investigation, November 1999, American Society for Clinical Investigation

    Edward K. L. Chan

  179. A Novel Cytoplasmic Protein with RNA-binding Motifs Is an Autoantigen in Human Hepatocellular Carcinoma

    Article • The Journal of Experimental Medicine, April 1999, Rockefeller University Press

    Edward K. L. Chan

  180. mRNA and Protein Expression of SSA/Ro and SSB/La in Human Fetal Cardiac Myocytes Cultured Using a Novel Application of the Langendorff Procedure

    Article • Pediatric Research, February 1999, Springer Science + Business Media

    Edward K. L. Chan

  181. Genetic and Physical Mapping of theLpsLocus: Identification of the Toll-4 Receptor as a Candidate Gene in the Critical Region

    Article • Blood Cells Molecules and Diseases, September 1998, Elsevier

    Edward K. L. Chan

  182. Molecular remedy of complex I defects: Rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells

    Article • Proceedings of the National Academy of Sciences, August 1998, Proceedings of the National Academy of Sciences

    Edward K. L. Chan

  183. Article • Journal of Molecular Medicine, January 1998, Springer Science + Business Media

    Edward K. L. Chan

  184. Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: Immunological relationship with hnRNP P

    Article • Nucleic Acids Research, January 1998, Oxford University Press (OUP)

    Edward K. L. Chan

  185. Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjögren's syndrome

    Article • Arthritis & Rheumatism, September 1997, Wiley

    Edward K. L. Chan

  186. Diversity of antinucelar antibody responses in hepatocellular carcinoma

    Article • Journal of Hepatology, July 1997, Elsevier

    Edward K. L. Chan

  187. Heterochromatin protein HP1 Hsβ (p25β) and its localization with centromeres in mitosis

    Article • Chromosoma, June 1997, Springer Science + Business Media

    Edward K. L. Chan

  188. The 52-kd protein as a target of intermolecular spreading of the immune response to components of the SS-A/Ro-SS-B/La complex

    Article • Arthritis & Rheumatism, May 1997, Wiley

    Edward K. L. Chan

  189. Cardiac expression of 52β, an alternative transcript of the congenital heart block-associated 52-kd SS-A/Ro autoantigen, is maximal during fetal development

    Article • Arthritis & Rheumatism, April 1997, Wiley

    Edward K. L. Chan

  190. Molecular Cloning of the RNA Polymerase I Transcription Factor hUBF/NOR-90 (UBTF) Gene and Localization to 17q21.3 by Fluorescencein SituHybridization and Radiation Hybrid Mapping

    Article • Genomics, April 1997, Elsevier

    Edward K. L. Chan

  191. Analysis of an exon 1 polymorphism of the B2 bradykinin receptor gene and its transcript in normal subjects and patients with C1 inhibitor deficiency

    Article • Journal of Allergy and Clinical Immunology, January 1997, Elsevier

    Edward K. L. Chan

  192. 17-β-Estradiol Increases Expression of 52-kDa and 60-kDa SS-A/Ro Autoantigens in Human Keratinocytes and Breast Cancer Cell Line MCF-7

    Article • Journal of Investigative Dermatology, October 1996, Elsevier

    Edward K. L. Chan

  193. Simplifying 5′RACE in the hunt for full-length cDNAs

    Article • Trends in Genetics, October 1996, Elsevier

    Edward K. L. Chan

  194. Two major autoantigen—Antibody systems of the mitotic spindle apparatus

    Article • Arthritis & Rheumatism, October 1996, Wiley

    Edward K. L. Chan

  195. Comparison of protocols for depleting anti-E. coli antibody in immunoblotting of recombinant antigens

    Article • Journal of Immunological Methods, March 1996, Elsevier

    Edward K. L. Chan

  196. Biographical sketch and scientific contributions of Eng M. Tan

    Article • Molecular Biology Reports, January 1996, Springer Science + Business Media

    Edward K. L. Chan

  197. Cloning and expression of mouse 60 kDa ribonucleoprotein SS-A/Ro

    Article • Molecular Biology Reports, January 1996, Springer Science + Business Media

    Edward K. L. Chan

  198. Foreword

    Article • Molecular Biology Reports, January 1996, Springer Science + Business Media

    Edward K. L. Chan

  199. Molecular Characterization of Golgin-245, a Novel Golgi Complex Protein Containing a Granin Signature

    Article • Journal of Biological Chemistry, December 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    Edward K. L. Chan

  200. 52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart

    Article • The Journal of Experimental Medicine, October 1995, Rockefeller University Press

    Edward K. L. Chan

  201. A Cell-Cycle Nuclear Autoantigen Containing Wd-40 Motifs Expressed Mainly in S and G2-Phase Cells

    Article • Biochemical and Biophysical Research Communications, February 1995, Elsevier

    Edward K. L. Chan

  202. A microscale method for depleting cross-reactive anti-antibodies used in indirect immunofluorescence microscopy

    Article • Journal of Immunological Methods, December 1994, Elsevier

    Edward K. L. Chan

  203. Human 60-kDa SS-A/Ro Ribonucleoprotein Autoantigen Gene (SSA2) Localized to 1q31 by Fluorescence in Situ Hybridization

    Article • Genomics, September 1994, Elsevier

    Edward K. L. Chan

  204. Is the Coiled Body Involved in Nucleolar Functions?

    Article • Experimental Cell Research, April 1994, Elsevier

    Edward K. L. Chan

  205. Immunocytochemical characterization of human NOR-90 (upstream binding factor) and associated antigens reactive with autoimmune sera

    Article • Molecular Biology Reports, March 1994, Springer Science + Business Media

    Edward K. L. Chan

  206. Structure, expression and chromosomal localization of human p80-coilin gene

    Article • Nucleic Acids Research, January 1994, Oxford University Press (OUP)

    Edward K. L. Chan

  207. Isolated congenital heart block. long-term outcome of mothers and characterization of the immune response to ss-a/ro and to ss-b/la

    Article • Arthritis & Rheumatism, November 1993, Wiley

    Edward K. L. Chan

  208. Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma.

    Article • Journal of Clinical Investigation, November 1993, American Society for Clinical Investigation

    Edward K. L. Chan

  209. Characterization of Antinuclear Autoantibodies Present in the Serum from Nonobese Diabetic (NOD) Mice

    Article • Clinical Immunology and Immunopathology, September 1993, Elsevier

    Edward K. L. Chan

  210. Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex

    Article • The Journal of Experimental Medicine, July 1993, Rockefeller University Press

    Edward K. L. Chan

  211. Immunocytochemical analysis of the coiled body in the cell cycle and during cell proliferation.

    Article • Proceedings of the National Academy of Sciences, March 1993, Proceedings of the National Academy of Sciences

    Edward K. L. Chan

  212. Autoantibodies in Viral Hepatitis-Related Hepatocellular Carcinoma

    Article • Intervirology, January 1993, Karger Publishers

    Edward K. L. Chan

  213. Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor

    Article • The Journal of Experimental Medicine, November 1991, Rockefeller University Press

    Edward K. L. Chan

  214. Immunological and ultrastructural studies of the nuclear coiled body with autoimmune antibodies

    Article • Experimental Cell Research, July 1991, Elsevier

    Edward K. L. Chan

  215. Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin

    Article • The Journal of Experimental Medicine, June 1991, Rockefeller University Press

    Edward K. L. Chan

  216. Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: a unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex

    Article • The Journal of Experimental Medicine, April 1991, Rockefeller University Press

    Edward K. L. Chan

  217. Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen.

    Article • Journal of Clinical Investigation, January 1991, American Society for Clinical Investigation

    Edward K. L. Chan

  218. Association between the nucleolus and the coiled body

    Article • Journal of Structural Biology, July 1990, Elsevier

    Edward K. L. Chan

  219. In vitro posttranslational modification of lamin B cloned from a human T-cell line.

    Article • Molecular and Cellular Biology, May 1990, ASM Journals

    Edward K. L. Chan

  220. Effective separation of the 52 kDa SSA/Ro polypeptide from the 48 kDa SSB/La polypeptide by altering conditions of polyacrylamide gel electrophoresis

    Article • Journal of Immunological Methods, May 1990, Elsevier

    Edward K. L. Chan

  221. Sjögren's syndrome nuclear antigen B (La): cDNA cloning, structural domains, and autoepitopes

    Article • Journal of Autoimmunity, August 1989, Elsevier

    Edward K. L. Chan

  222. Viral genomes in lymphomas of patients with Sjögren's Syndrome

    Article • Journal of Autoimmunity, August 1989, Elsevier

    Edward K. L. Chan

  223. Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding

    Article • Nucleic Acids Research, January 1989, Oxford University Press (OUP)

    Edward K. L. Chan

  224. A 52-kD protein is a novel component of the SS-A/Ro antigenic particle

    Article • The Journal of Experimental Medicine, May 1988, Rockefeller University Press

    Edward K. L. Chan

  225. Antinuclear antibodies (ANAs): Diagnostically specific immune markers and clues toward the understanding of systemic autoimmunity

    Article • Clinical Immunology and Immunopathology, May 1988, Elsevier

    Edward K. L. Chan

  226. Human autoantibody-reactive epitopes of SS-B/La are highly conserved in comparison with epitopes recognized by murine monoclonal antibodies

    Article • The Journal of Experimental Medicine, December 1987, Rockefeller University Press

    Edward K. L. Chan

  227. The small nuclear ribonucleoprotein SS-B/La binds RNA with a conserved protease-resistant domain of 28 kilodaltons.

    Article • Molecular and Cellular Biology, July 1987, ASM Journals

    Edward K. L. Chan

  228. Monoclonal autoantibodies to nuclear antigens from murine graft-versus-host disease

    Article • Clinical Immunology and Immunopathology, July 1987, Elsevier

    Edward K. L. Chan

  229. An immunoassay differentiating sera with antibodies to sm alone, antibodies to sm/RNP complex, and antibodies to RNP alone

    Article • Arthritis & Rheumatism, April 1987, Wiley

    Edward K. L. Chan

  230. Antibodies against small nuclear ribonucleoproteins immunoprecipitate complexes containing ts110 moloney murine sarcoma virus genomic and messenger RNAs

    Article • Virology, July 1986, Elsevier

    Edward K. L. Chan

  231. Effect of Cationic Proteins on the Glomerular Deposition of Anionic Proteins and Immune Complexes

    Article • January 1986, Karger Publishers

    Edward K. L. Chan

  232. Characterization and purification of lupus antigen La, and RNA-binding protein.

    Article • Molecular and Cellular Biology, March 1985, ASM Journals

    Edward K. L. Chan

  233. Preparation of covalently linked immune complexes of specific composition

    Article • Journal of Immunological Methods, March 1980, Elsevier

    Edward K. L. Chan