Modeling the proteins in the Zika virus

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This work was inspired by John who wanted to illustrate the virus. This triggered me to model all the proteins and pull a team of other scientists together to get their comments and insights. Carolina's group did further analysis and work to ensure the protein models looked good. The work transpired over a couple of weeks in February 2016. All the models were also initially deposited in Figshare.

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I came to the party a little late on this one but I had been both collating some anti-Dengue chemistry and doing some sequence analysis on my blog which I was able to adapt to fit the publication. The amino acid similarity statistics are important for judging the plausibility of getting target models that have real utility for VS work and docking. In addition they can suggest a priority triage for experimental screening (i.e. in this case we can preict that target-based anti-Dengue cpds shoud cross-inhibit more than HCV inhibitors). I hope to expand on these aspects when we revise the submission.

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