What is it about?
We review the recent evidence that indicates that adenosine (what we call a hypoadenosinergic state) plays a major role in the pathogenesis of all thes symptomatology of Restless Legs Syndrome (RLS)
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Why is it important?
It provides a new potential therapeutic target. In fact, we predicted that a drug that increases adenosine in the brain (dipyridamole) would be beneficial and we just found its efficacy for RLS in an open trial (mentioned in the text)
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations and that are celebrities in the clinical research of RLS
Sergi Ferre
National Institute on Drug Abuse, Intramural Research Program
Read the Original
This page is a summary of: New Insights into the Neurobiology of Restless Legs Syndrome, The Neuroscientist, July 2018, SAGE Publications,
DOI: 10.1177/1073858418791763.
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