Applications and Approaches for Three-Dimensional Precision-Cut Lung Slices. Disease Modeling and Drug Discovery

What is it about?

Chronic lung diseases (CLDs) are among the leading causes of morbidity globally and present a major health and financial burden on patients and society. Effective treatments are scarce and relevant human model systems to effectively study CLD pathomechanisms and thus discover and validate potential new targets and therapies are needed. Precision-cut lung slices (PCLS) represent one promising tool which can closely recapitulate the complexity of the lung’s native environment, In this review, we discuss approaches that utilize human PCLS for advancing our understanding of CLD development as well as drug discovery and validation for CLDs.

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