What is it about?
Transverse tubules are specialised structures forming part of the cell membrane of heart muscle cells and are important in regulating the amount of force the heart can generate. Here we show that a particular protein, AmpII (also known as BIN1) is required for the maintenance of transverse tubules.
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Why is it important?
In cardiac diseases such as heart failure and atrial fibrillation the amount of transverse tubules in heart muscle cells is reduced. The loss of transverse tubules is one of the mechanisms by which the force of contraction is reduced and it may also be linked to an increase in rhythm disturbances seen in these diseases. By identifying a key protein that controls transverse tubule turnover novel therapeutic approaches to restore contractile force in heart failure could be realised.
Perspectives
Working with such an enthusiastic and dedicated team was really rewarding and the results were always exciting to observe.
Professor Andrew Trafford
University of Manchester
Read the Original
This page is a summary of: Dependence of Cardiac Transverse Tubules on the BAR Domain Protein Amphiphysin II (BIN-1), Circulation Research, October 2014, Wolters Kluwer Health,
DOI: 10.1161/circresaha.116.303448.
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