All Stories

  1. Chronic vagal nerve stimulation has no effect on tachycardia‐induced heart failure progression or excitation–contraction coupling

    Article • Physiological Reports, January 2020, Wiley

    Professor Andrew Trafford

  2. Understanding why cardiac function is altered by ageing

    Article • The Journal of Physiology, September 2017, Wiley

    Katharine Dibb, Professor Andrew Trafford

  3. A model model: a commentary on DiFrancesco and Noble (1985) 'A model of cardiac electrical activity incorporating ionic pumps and concentration changes'

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, March 2015, Royal Society Publishing

    Professor Andrew Trafford

  4. MAPS; acute safety data of the St Jude accent - tendril IPG system during prolonged max power CMR scanning

    Article • Journal of Cardiovascular Magnetic Resonance, January 2015, Springer Science + Business Media

    Professor Andrew Trafford

  5. Sildenafil protects against heart attacks in patients with type II diabetes

    Article • Artery Research, December 2014, Elsevier

    Professor Andrew Trafford

  6. The protein AmpII (BIN1) regulates transverse tubules in the heart

    Article • Circulation Research, October 2014, Wolters Kluwer Health

    Professor Andrew Trafford

  7. Balanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during β-adrenergic stimulation in cardiac myocytes

    Article • Cardiovascular Research, September 2014, European Society of Cardiology

    Professor Andrew Trafford

  8. Direct measurements of SR free Ca reveal the mechanism underlying the transient effects of RyR potentiation under physiological conditions

    Article • Cardiovascular Research, June 2014, European Society of Cardiology

    Professor Andrew Trafford

  9. An Induced Pluripotent Stem Cell Model of Hypoplastic Left Heart Syndrome (HLHS) Reveals Multiple Expression and Functional Differences in HLHS-Derived Cardiac Myocytes

    Article • Stem Cells Translational Medicine, March 2014, Wiley

    Professor Andrew Trafford

  10. Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response

    Article • Biochemical Journal, December 2013, Portland Press Ltd.

    Professor Andrew Trafford

  11. Sarcoplasmic Reticulum Ca-ATPase and Heart Failure 20 Years Later

    Article • Circulation Research, September 2013, Wolters Kluwer Health

    Professor Andrew Trafford

  12. Three-Dimensional Reconstruction of Cardiac Sarcoplasmic Reticulum Reveals a Continuous Network Linking Transverse-Tubules: This Organization Is Perturbed in Heart Failure

    Article • Circulation Research, September 2013, Wolters Kluwer Health

    Professor Andrew Trafford

  13. A functional role for transverse (t-) tubules in the atria

    Article • Journal of Molecular and Cellular Cardiology, May 2013, Elsevier

    Professor Andrew Trafford

  14. Calcium flux balance in the heart

    Article • Journal of Molecular and Cellular Cardiology, May 2013, Elsevier

    Professor Andrew Trafford

  15. Calcium signalling microdomains and the t-tubular system in atrial mycoytes: potential roles in cardiac disease and arrhythmias

    Article • Cardiovascular Research, February 2013, European Society of Cardiology

    Professor Andrew Trafford

  16. Effects of phosphodiesterase type 5A inhibition on intracellular calcium handling and its implications for cardioprotection and antiarrhythmogenesis

    Article • The Lancet, February 2013, Elsevier

    Professor Andrew Trafford

  17. Diastolic Spontaneous Calcium Release From the Sarcoplasmic Reticulum Increases Beat-to-Beat Variability of Repolarization in Canine Ventricular Myocytes After  -Adrenergic Stimulation

    Article • Circulation Research, November 2012, Wolters Kluwer Health

    Dr Daniel Johnson, Professor Andrew Trafford

  18. Age-related divergent remodeling of the cardiac extracellular matrix in heart failure: Collagen accumulation in the young and loss in the aged

    Article • Journal of Molecular and Cellular Cardiology, July 2012, Elsevier

    Professor Andrew Trafford

  19. Enhanced Sarcoplasmic Reticulum Ca2+ Leak and Increased Na+-Ca2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial Fibrillation

    Article • Circulation, March 2012, Wolters Kluwer Health

    Professor Andrew Trafford

  20. Localised micro-mechanical stiffening in the ageing aorta

    Article • Mechanisms of Ageing and Development, October 2011, Elsevier

    Brian Derby, Professor Andrew Trafford

  21. Changes of SERCA activity have only modest effects on sarcoplasmic reticulum Ca2+content in rat ventricular myocytes

    Article • The Journal of Physiology, September 2011, Wiley

    Professor Andrew Trafford

  22. Transverse tubules are a common feature in large mammalian atrial myocytes including human

    Article • AJP Heart and Circulatory Physiology, August 2011, American Physiological Society

    Professor Andrew Trafford

  23. The devil is in the details: Methodological reviews—A new JMCC initiative

    Article • Journal of Molecular and Cellular Cardiology, June 2011, Elsevier

    Professor Andrew Trafford

  24. How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

    Article • Bone Marrow Transplantation, May 2011, Wiley

    Professor Andrew Trafford

  25. Impaired β-adrenergic responsiveness accentuates dysfunctional excitation-contraction coupling in an ovine model of tachypacing-induced heart failure

    Article • The Journal of Physiology, March 2011, Wiley

    Professor Andrew Trafford

  26. Ca2+ wave probability is determined by the balance between SERCA2-dependent Ca2+ reuptake and threshold SR Ca2+ content

    Article • Cardiovascular Research, January 2011, European Society of Cardiology

    Professor Andrew Trafford

  27. Primum non nocere: When will ryanodine receptor leak find its role in heart failure?

    Article • Journal of Molecular and Cellular Cardiology, January 2011, Elsevier

    Professor Andrew Trafford

  28. In the RyR2R4496C Mouse Model of CPVT,  -Adrenergic Stimulation Induces Ca Waves by Increasing SR Ca Content and Not by Decreasing the Threshold for Ca Waves

    Article • Circulation Research, October 2010, Wolters Kluwer Health

    Professor Andrew Trafford

  29. How does CaMKIIδ phosphorylation of the cardiac ryanodine receptor contribute to inotropy?

    Article • Proceedings of the National Academy of Sciences, July 2010, Proceedings of the National Academy of Sciences

    Professor Andrew Trafford

  30. Tissue section AFM: In situ ultrastructural imaging of native biomolecules

    Article • Matrix Biology, May 2010, Elsevier

    A/Prof Thomas R Cox, Professor Andrew Trafford

  31. Calcium Signaling in Cardiac Muscle

    Article • January 2010, Elsevier

    Professor Andrew Trafford

  32. Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes

    Article • Cardiovascular Research, December 2009, European Society of Cardiology

    Professor Andrew Trafford

  33. Keeping the beat: Life without SERCA — Is it possible?

    Article • Journal of Molecular and Cellular Cardiology, August 2009, Elsevier

    Professor Andrew Trafford

  34. Characterization of an Extensive Transverse Tubular Network in Sheep Atrial Myocytes and its Depletion in Heart Failure

    Article • Circulation Heart Failure, July 2009, Wolters Kluwer Health

    Professor Andrew Trafford

  35. What is the purpose of the large sarcolemmal calcium flux on each heartbeat?

    Article • AJP Heart and Circulatory Physiology, June 2009, American Physiological Society

    Professor Andrew Trafford

  36. The mechanism and significance of the slow changes of ventricular action potential duration following a change of heart rate

    Article • Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, April 2009, Wiley

    Professor Andrew Trafford

  37. Differences in intracellular calcium homeostasis between atrial and ventricular myocytes

    Article • Journal of Molecular and Cellular Cardiology, April 2009, Elsevier

    Professor Andrew Trafford

  38. What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis?

    Article • Journal of Molecular and Cellular Cardiology, April 2009, Elsevier

    Professor Andrew Trafford

  39. Nanoindentation of histological specimens: Mapping the elastic properties of soft tissues

    Article • Journal of Materials Research, March 2009, Cambridge University Press

    Brian Derby, Professor Andrew Trafford

  40. From the Ryanodine Receptor to Cardiac Arrhythmias

    Article • Circulation Journal, January 2009, Japanese Circulation Society

    Professor Andrew Trafford

  41. Extracellular matrix profiles in the progression to heart failure

    Article • Acta Physiologica, September 2008, Wiley

    Professor Andrew Trafford

  42. Regulation of systolic [Ca2+]iand cellular Ca2+flux balance in rat ventricular myocytes by SR Ca2+, L-type Ca2+current and diastolic [Ca2+]i

    Article • The Journal of Physiology, December 2007, Wiley

    Professor Andrew Trafford

  43. Analysis of cellular calcium fluxes in cardiac muscle to understand calcium homeostasis in the heart

    Article • Cell Calcium, October 2007, Elsevier

    Professor Andrew Trafford

  44. The sarcoplasmic reticulum and arrhythmogenic calcium release

    Article • Cardiovascular Research, September 2007, European Society of Cardiology

    Professor Andrew Trafford

  45. Na/Ca Exchange: Regulator of Intracellular Calcium and Source of Arrhythmias in the Heart

    Article • Annals of the New York Academy of Sciences, February 2007, Wiley

    Professor Andrew Trafford

  46. Increasing Ryanodine Receptor Open Probability Alone Does Not Produce Arrhythmogenic Calcium Waves: Threshold Sarcoplasmic Reticulum Calcium Content Is Required

    Article • Circulation Research, January 2007, Wolters Kluwer Health

    Professor Andrew Trafford

  47. Spatial disruption and enhanced degradation of collagen with the transition from compensated ventricular hypertrophy to symptomatic congestive heart failure

    Article • AJP Heart and Circulatory Physiology, October 2006, American Physiological Society

    Professor Andrew Trafford

  48. Life, Sudden Death, and Intracellular Calcium

    Article • Circulation Research, August 2006, Wolters Kluwer Health

    Professor Andrew Trafford

  49. Reducing Ryanodine Receptor Open Probability as a Means to Abolish Spontaneous Ca2+ Release and Increase Ca2+ Transient Amplitude in Adult Ventricular Myocytes

    Article • Circulation Research, May 2006, Wolters Kluwer Health

    Professor Andrew Trafford

  50. A mechanism distinct from the L-type Ca current or Na–Ca exchange contributes to Ca entry in rat ventricular myocytes

    Article • Cell Calcium, May 2006, Elsevier

    Professor Andrew Trafford

  51. The control of sarcoplasmic reticulum Ca content in cardiac muscle

    Article • Cell Calcium, September 2005, Elsevier

    Professor Andrew Trafford

  52. Stability and instability of regulation of intracellular calcium

    Article • Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, December 2004, Wiley

    Professor Andrew Trafford

  53. Photoperiod-dependent modulation of cardiac excitation contraction coupling in the Siberian hamster

    Article • AJP Regulatory Integrative and Comparative Physiology, November 2004, American Physiological Society

    Professor Andrew Trafford

  54. Mechanisms underlying enhanced cardiac excitation contraction coupling observed in the senescent sheep myocardium

    Article • Journal of Molecular and Cellular Cardiology, November 2004, Elsevier

    Professor Andrew Trafford

  55. Enhanced sarcolemmal Ca2+ efflux reduces sarcoplasmic reticulum Ca2+ content and systolic Ca2+ in cardiac hypertrophy

    Article • Cardiovascular Research, June 2004, European Society of Cardiology

    Professor Andrew Trafford

  56. Physiological and pathological modulation of ryanodine receptor function in cardiac muscle

    Article • Cell Calcium, June 2004, Elsevier

    Professor Andrew Trafford

  57. DYNAMICS OF CARDIAC INTRACELLULAR Ca 2+ HANDLING — FROM EXPERIMENTS TO VIRTUAL CELLS

    Article • International Journal of Bifurcation and Chaos, December 2003, World Scientific Pub Co Pte Lt

    Henggui Zhang, Professor Andrew Trafford

  58. Location, location, location: new avenues to determine the function of the cardiac Na+–Ca2+ exchanger?

    Article • Journal of Molecular and Cellular Cardiology, November 2003, Elsevier

    Professor Andrew Trafford

  59. Illuminating Sarcoplasmic Reticulum Calcium

    Article • Circulation Research, July 2003, Wolters Kluwer Health

    Professor Andrew Trafford

  60. No role for a voltage sensitive release mechanism in cardiac muscle

    Article • Journal of Molecular and Cellular Cardiology, February 2003, Elsevier

    Professor Andrew Trafford

  61. Heart Failure and the Ryanodine Receptor: Does Occam's Razor Rule?

    Article • Circulation Research, November 2002, Wolters Kluwer Health

    Professor Andrew Trafford

  62. The role of intracellular Ca buffers in determining the shape of the systolic Ca transient in cardiac ventricular myocytes

    Article • Pflügers Archiv - European Journal of Physiology, February 2001, Springer Science + Business Media

    Professor Andrew Trafford

  63. The effect of acidosis on systolic Ca2+and sarcoplasmic reticulum calcium content in isolated rat ventricular myocytes

    Article • The Journal of Physiology, December 2000, Wiley

    Professor Andrew Trafford

  64. The effects of low concentrations of caffeine on spontaneous Ca release in isolated rat ventricular myocytes

    Article • Cell Calcium, October 2000, Elsevier

    Professor Andrew Trafford

  65. The Ryanodine Receptor: Cause or Consequence of Diabetic Heart Failure?

    Article • Journal of Molecular and Cellular Cardiology, July 2000, Elsevier

    Professor Andrew Trafford

  66. Can changes of ryanodine receptor expression affect cardiac contractility?

    Article • Cardiovascular Research, March 2000, European Society of Cardiology

    Professor Andrew Trafford

  67. Measurement of calcium entry and exit in quiescent rat ventricular myocytes

    Article • Pflügers Archiv - European Journal of Physiology, January 2000, Springer Science + Business Media

    Professor Andrew Trafford

  68. A novel, rapid and reversible method to measure Ca buffering and time-course of total sarcoplasmic reticulum Ca content in cardiac ventricular myocytes

    Article • Pflügers Archiv - European Journal of Physiology, January 1999, Springer Science + Business Media

    Professor Andrew Trafford

  69. 2,3-Butanedione monoxime (BDM) decreases sarcoplasmic reticulum Ca content by stimulating Ca release in isolated rat ventricular myocytes

    Article • Pflügers Archiv - European Journal of Physiology, August 1998, Springer Science + Business Media

    Professor Andrew Trafford

  70. The control of Ca release from the cardiac sarcoplasmic reticulum: regulation versus autoregulation

    Article • Cardiovascular Research, June 1998, European Society of Cardiology

    Professor Andrew Trafford

  71. Ca-activated chloride current and Na-Ca exchange have different timecourses during sarcoplasmic reticulum Ca release in ferret ventricular myocytes

    Article • Pflügers Archiv - European Journal of Physiology, March 1998, Springer Science + Business Media

    Professor Andrew Trafford

  72. Stimulation of Ca-induced Ca release only transiently increases the systolic Ca transient: measurements of Ca fluxes and sarcoplasmic reticulum Ca

    Article • Cardiovascular Research, March 1998, European Society of Cardiology

    Professor Andrew Trafford

  73. A measurable reduction of s.r. Ca content follows spontaneous Ca release in rat ventricular myocytes

    Article • Pflügers Archiv - European Journal of Physiology, September 1997, Springer Science + Business Media

    Professor Andrew Trafford

  74. Measurement of sarcoplasmic reticulum Ca2+content and sarcolemmal Ca2+fluxes in isolated rat ventricular myocytes during spontaneous Ca2+release

    Article • The Journal of Physiology, May 1997, Wiley

    Professor Andrew Trafford

  75. Factors affecting the propagation of locally activated systolic Ca transients in rat ventricular myocytes

    Article • Pflügers Archiv - European Journal of Physiology, October 1993, Springer Science + Business Media

    Professor Andrew Trafford