What is it about?
We demonstrate that inosine incorporation into viral RNA can potentiate TLR7/8 activation.
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Why is it important?
Our findings indicate that inosine modification of viral RNA by the RNA editing machinery can act to potentiate recognition of viral RNA by TLR7/8 during phagocytosis of infected cells. This is a novel role for A to I RNA editing.
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This page is a summary of: Inosine-Mediated Modulation of RNA Sensing by Toll-Like Receptor 7 (TLR7) and TLR8, Journal of Virology, November 2013, ASM Journals,
DOI: 10.1128/jvi.01571-13.
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