Mechanism based drug discovery against Mycobacterium abscessus by targeting L,D-transpeptidases

What is it about?

Mycobacterium abscessus is a mycobacteria that causes infections in cystic fibrosis and immunocompromised patients. This is a big problem in United States. This bacterium is resistant to major antibiotics and is the major cause of death in cystic fibrosis patients. The current research screened several ß-lactam class of drugs against L,D-transpeptidase enzymes from M. abscessus and used these information to develop dual ß-lactam drugs combination for the treatment of M. abscessus infections. The study also revealed structural and molecular basis of inhibition of L,D-transpeptidases by ß-lactams

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Why is it important?

This study us very important that has lead to development of new treatment method for Mycobacterium abscessus infections. This is very important for cystic fibrosis patients in United States.