What is it about?
Experiments in vitro and in cells show that the protein kinases Mps1 binds to the kinetochores of the replicated chromosomes, "sensing" if microtubules have attached. When microtubules attach, Mps1 is expelled, and that is one of the major signals that tells the cell that division can proceed.
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Why is it important?
The involvement of Mps1 in "sensing" proper microtubule attachment has been clear for a number of years: in this paper we provide how this can be made physically possible by direct competition with microtubules.
Perspectives
This work allowed novel insight to a fundamental cell mechanism and sets the ground for further work that can result to specific inhibitors targeting cells with cell division defects, as in cancer.
Dr Anastassis Perrakis
netherlands cancer institute
Read the Original
This page is a summary of: Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling, Science, June 2015, American Association for the Advancement of Science,
DOI: 10.1126/science.aaa4055.
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