What is it about?
TNF in the brain is associated with neurologic impairment in animal models of cerebral malaria. In this study, cerebrospinal fluid levels of TNF were again shown to be associated with long-term neurologic and cognitive impairment in children >5 years of age.
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Why is it important?
The findings suggest that interventions that decrease CNS TNF production might decrease long-term neurologic and cognitive impairment in children with cerebral malaria.
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This page is a summary of: Elevated cerebrospinal fluid tumour necrosis factor is associated with acute and long-term neurocognitive impairment in cerebral malaria, Parasite Immunology, May 2017, Wiley,
DOI: 10.1111/pim.12438.
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