What is it about?
In this review, we discuss the functions of and the metabolic pathways linked to the mitochondrial complex III, which is a key mitochondrial respiratory enzyme complex, and the electron carrier coenzyme Q (ubiquinone), which is reoxidized by CIII.
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Why is it important?
Mutations that compromise CIII function or coenzyme Q biosynthesis cause severe genetic diseases (mitochondrial diseases) in humans. These diseases are mostly untreatable and the underlying mechanisms poorly known, hindering development of therapies.
Perspectives
This review was a fruit of the COVID times in our research group, when lab work was restricted. It was a lot of work but well worth it.
Dr Jukka Kallijärvi
Folkhälsan Research Center
Read the Original
This page is a summary of: The mitochondrial coenzyme Q junction and complex III: biochemistry and pathophysiology, FEBS Journal, August 2021, Wiley,
DOI: 10.1111/febs.16164.
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