GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability

What is it about?

TREK two pore domain potassium channels regulate the excitability of dorsal root ganglion neurons and therefore the response to painful stimuli. In this paper, we describe a novel activator of TREK channels that reduces the excitability of these neurons. This may be important for the development of novel therapies to reduce pain.

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