What is it about?
The small Rab GTPases are key regulators of membrane vesicle trafficking. We cloned a cDNA encoding Rab5 from the American cockroach, P. americana, ovaries (PamRab5). The PamRab5 during late vitellogenic periods is required to regulate the endocytotic machinery during oogenesis in this cockroach.
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Why is it important?
This is the first report on Rab5 from a hemimetabolan, and presents an inaugural step in probing the molecular premises of insect oocyte endocytotic trafficking important for oogenesis and embryonic development.
Perspectives
Rab GTPases are found in all eukaryotes. Rab proteins regulate intracellular membrane trafficking events and Rab5 is a key regulator of insect oogenesis
Mohamed Elmoogy
Department of Entomology, Faculty of Science, Cairo University
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This page is a summary of: Molecular and functional characterization of the American cockroach, Periplaneta americana
, Rab5: the first exopterygotan low molecular weight ovarian GTPase during oogenesis, Insect Science, August 2017, Wiley,
DOI: 10.1111/1744-7917.12485.
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