What is it about?
In metazoan, replication-dependent histone (RDH) mRNAs are the only known cellular mRNAs that end in a highly conserved histone stem-loop structure rather than a poly(A) tail. However, poly(A)+ RDH mRNAs accumulate under certain physiological conditions, presumably by aberrant or inefficient processing. In this study, we show that under normal conditions poly(A)+ RDH mRNAs are rapidly destabilized. On the other hand, under stress conditions such as puromycin treatment or ultraviolet C irradiation, HuR binds to the extended 3'-untranslated region and thereby stabilizes poly(A)+ RDH mRNAs. Thus, we demonstrate that HuR regulates the expression of poly(A)+ RDH mRNAs depending on cellular environment.
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Why is it important?
Although several studies have revealed the presence of poly(A)+ RDH mRNAs, the functional significance and biogenesis of these transcripts remain unknown. Here, we provide compelling evidence that poly(A)+ RDH mRNAs are post-transcriptionally regulated via Hu antigen R (HuR) under stress conditions.
Perspectives
Our findings provide moelcular insights on a possible crosstalk between polyadenylated histone mRNA and cellular stress responses.
Yoon ki Kim
Korea University
Read the Original
This page is a summary of: HuR stabilizes a polyadenylated form of replication-dependent histone mRNAs under stress conditions, The FASEB Journal, February 2019, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.201800431r.
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