What is it about?
This work reveals a completely different way by which RNA binding proteins can bind to RNA, using unconventional motifs and sequences. This work was recommended by F1000, https://f1000.com/prime/735222235#eval793557531
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Why is it important?
Molecular details help with understanding the function of LARP4A, a very important RNA binding proteins involved in cancer. The importance and excellent of the work was noted by F1000 https://f1000.com/prime/735222235#eval793557531
Perspectives
This work challenges the conventional view of RNA recognition and shows even more atypical mechanisms in the superfamily of La-related proteins
Prof Maria Rosaria Conte
King's College London
Read the Original
This page is a summary of: LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA, Nucleic Acids Research, March 2019, Oxford University Press (OUP),
DOI: 10.1093/nar/gkz144.
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