All Stories

  1. The RNA binding proteins LARP4A and LARP4B promote sarcoma and carcinoma growth and metastasis

    Article • iScience, April 2024, Elsevier

    Prof Maria Rosaria Conte

  2. The metabolic effects of intermittent versus continuous feeding in critically ill patients

    Article • Scientific Reports, November 2023, Springer Science + Business Media

    Prof Maria Rosaria Conte

  3. LARP4A and LARP4B in cancer: The new kids on the block

    Article • The International Journal of Biochemistry & Cell Biology, August 2023, Elsevier

    Prof Maria Rosaria Conte

  4. AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration

    Article • Nature Communications, May 2023, Springer Science + Business Media

    Prof Maria Rosaria Conte

  5. Metabolic rewiring in MYC-driven medulloblastoma by BET-bromodomain inhibition

    Article • Scientific Reports, January 2023, Springer Science + Business Media

    Prof Maria Rosaria Conte

  6. Allosteric Regulation of the Soluble Epoxide Hydrolase by Nitro Fatty Acids: a Combined Experimental and Computational Approach

    Article • Journal of Molecular Biology, April 2022, Elsevier

    Prof Maria Rosaria Conte

  7. Structural basis of dimerization and nucleic acid binding of human DBHS proteins NONO and PSPC1

    Article • Nucleic Acids Research, December 2021, Oxford University Press (OUP)

    Prof Maria Rosaria Conte

  8. A thiol redox sensor in soluble epoxide hydrolase enables oxidative activation by intra-protein disulfide bond formation

    Article • Redox Biology, October 2021, Elsevier

    Prof Maria Rosaria Conte

  9. LARP6C orchestrates posttranscriptional reprogramming of gene expression during hydration to promote pollen tube guidance

    Article • The Plant Cell, May 2021, Oxford University Press (OUP)

    Prof Maria Rosaria Conte

  10. Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein–Protein Inhibitors: Two Test Cases Illustrated by IL1β-IL1R and p38α–TAB1 Complexes

    Article • Journal of Medicinal Chemistry, July 2020, American Chemical Society (ACS)

    Prof Maria Rosaria Conte

  11. Structural dynamics in the La-module of La-related proteins

    Article • RNA Biology, March 2020, Taylor & Francis

    Prof Maria Rosaria Conte

  12. Maternal Larp6 controls oocyte development, chorion formation and elevation

    Article • Development, February 2020, The Company of Biologists

    Prof Maria Rosaria Conte

  13. The La-related proteins: Structures and interactions of a versatile superfamily of RNA binding proteins

    Article • RNA Biology, November 2019, Taylor & Francis

    Prof Maria Rosaria Conte

  14. Isothermal Titration Calorimetry Enables Rapid Characterization of Enzyme Kinetics and Inhibition for the Human Soluble Epoxide Hydrolase

    Article • Analytical Chemistry, November 2019, American Chemical Society (ACS)

    Prof Maria Rosaria Conte

  15. PDXK mutations cause polyneuropathy responsive to pyridoxal 5′‐phosphate supplementation

    Article • Annals of Neurology, July 2019, Wiley

    Prof Maria Rosaria Conte, Professor Kyproula Christodoulou, Nourelhoda Haridy

  16. 15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism

    Article • Communications Biology, May 2019, Springer Science + Business Media

    Prof Maria Rosaria Conte

  17. The new molecular mechanisms of LARP4A

    Article • Nucleic Acids Research, March 2019, Oxford University Press (OUP)

    Prof Maria Rosaria Conte

  18. Resonance assignment of human LARP4A La module

    Article • Biomolecular NMR Assignments, January 2019, Springer Science + Business Media

    Prof Maria Rosaria Conte

  19. Expression, purification, and characterisation of human soluble Epoxide Hydrolase (hsEH) and of its functional C-terminal domain

    Article • Protein Expression and Purification, January 2019, Elsevier

    Prof Maria Rosaria Conte

  20. TAB1-Induced Autoactivation of p38α Mitogen-Activated Protein Kinase Is Crucially Dependent on Threonine 185

    Article • Molecular and Cellular Biology, December 2017, ASM Journals

    michael marber, Gian De Nicola, Prof Maria Rosaria Conte

  21. Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins

    Article • PLoS ONE, October 2017, PLOS

    Prof Maria Rosaria Conte

  22. The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives

    Article • Wiley Interdisciplinary Reviews - RNA, August 2017, Wiley

    Prof Maria Rosaria Conte

  23. Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response

    Article • Nature Communications, October 2016, Springer Science + Business Media

    Prof Maria Rosaria Conte

  24. The RNA-binding protein LARP4 regulates cancer cell migration and invasion

    Article • Cytoskeleton, September 2016, Wiley

    Prof Maria Rosaria Conte

  25. A crystallographic study of human NONO (p54nrb): overcoming pathological problems with purification, data collection and noncrystallographic symmetry

    Article • Acta Crystallographica Section D Structural Biology, May 2016, International Union of Crystallography

    Gavin Knott, Prof Maria Rosaria Conte

  26. 1H, 15N and 13C chemical shift assignments of the La motif and RRM1 from human LARP6

    Article • Biomolecular NMR Assignments, April 2015, Springer Science + Business Media

    Prof Maria Rosaria Conte

  27. Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module

    Article • Nucleic Acids Research, December 2014, Oxford University Press (OUP)

    Prof Maria Rosaria Conte

  28. Solution Structure of the SGTA Dimerisation Domain and Investigation of Its Interactions with the Ubiquitin-Like Domains of BAG6 and UBL4A

    Article • PLoS ONE, November 2014, PLOS

    Prof Maria Rosaria Conte

  29. Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1

    Article • Nature Structural & Molecular Biology, September 2013, Nature

    Dr Pierre Sicard, Prof Maria Rosaria Conte

  30. The association of a La module with the PABP-interacting motif PAM2 is a recurrent evolutionary process that led to the neofunctionalization of La-related proteins

    Article • RNA, November 2012, Cold Spring Harbor Laboratory Press

    Prof Maria Rosaria Conte

  31. RNA Chaperone Activity of Human La Protein Is Mediated by Variant RNA Recognition Motif

    Article • Journal of Biological Chemistry, December 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Maria Rosaria Conte

  32. Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein

    Article • Nucleic Acids Research, October 2011, Oxford University Press (OUP)

    Prof Maria Rosaria Conte

  33. A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies

    Article • Biochimie, August 2011, Elsevier

    Prof Maria Rosaria Conte

  34. Structure and Genetic Analysis of the Arterivirus Nonstructural Protein 7 

    Article • Journal of Virology, May 2011, ASM Journals

    Prof Maria Rosaria Conte

  35. La-Related Protein 4 Binds Poly(A), Interacts with the Poly(A)-Binding Protein MLLE Domain via a Variant PAM2w Motif, and Can Promote mRNA Stability

    Article • Molecular and Cellular Biology, November 2010, ASM Journals

    Prof Maria Rosaria Conte

  36. Resonance assignment of nsp7α from arterivirus

    Article • Biomolecular NMR Assignments, August 2010, Springer Science + Business Media

    Prof Maria Rosaria Conte

  37. Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA

    Article • Nucleic Acids Research, March 2010, Oxford University Press (OUP)

    Prof Maria Rosaria Conte

  38. Letter to the Editor: Resonance assignment of SlyD from E. coli

    Article • Biomolecular NMR Assignments, September 2009, Springer Science + Business Media

    Prof Maria Rosaria Conte

  39. Getting to the end of RNA: Structural analysis of protein recognition of 5′ and 3′ termini

    Article • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, September 2009, Elsevier

    Prof Maria Rosaria Conte

  40. The interaction of theEscherichia coliprotein SlyD with nickel ions illuminates the mechanism of regulation of its peptidyl-prolyl isomerase activity

    Article • FEBS Journal, August 2009, Wiley

    Prof Maria Rosaria Conte

  41. NMR assignment of the N-terminal region of human La free and in complex with RNA

    Article • Biomolecular NMR Assignments, June 2008, Springer Science + Business Media

    Prof Maria Rosaria Conte

  42. Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3′ Ends by the Human La Protein

    Article • Structure, June 2008, Elsevier

    Prof Maria Rosaria Conte

  43. A terminal affair: 3′-end recognition by the human La protein

    Article • Trends in Biochemical Sciences, June 2006, Elsevier

    Prof Maria Rosaria Conte

  44. Resonance assignment for the N-terminal region of the eukaryotic initiation factor 5 (eIF5)

    Article • Journal of Biomolecular NMR, June 2006, Springer Science + Business Media

    Prof Maria Rosaria Conte

  45. Structure of the Eukaryotic Initiation Factor (eIF) 5 Reveals a Fold Common to Several Translation Factors†,‡

    Article • Biochemistry, April 2006, American Chemical Society (ACS)

    Prof Maria Rosaria Conte

  46. Structure and RNA Interactions of the N-Terminal RRM Domains of PTB

    Article • Structure, September 2004, Elsevier

    Professor Stephen Curry, Prof Maria Rosaria Conte

  47. Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein

    Article • Nature Structural & Molecular Biology, March 2004, Springer Science + Business Media

    Prof Maria Rosaria Conte

  48. Structure of the C-Terminal Domain of Human La Protein Reveals a Novel RNA Recognition Motif Coupled to a Helical Nuclear Retention Element

    Article • Structure, July 2003, Elsevier

    Prof Maria Rosaria Conte