What is it about?
We discovered that inhibition (KDM4B)activates KDM1A, which removes methyl groups from histone 3 lysine 4. This shuts down the gene making inflammatory cytokines, reducing inflammation and bone.
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Why is it important?
This could be a potential treatment for periodontal disease, which affects almost 50% of the US population.
Perspectives
This is the first example of systematic drug discovery being used to find a treatment for periodontal disease.
Prof. Patrick M. Woster
Medical University of South Carolina
Read the Original
This page is a summary of: Inhibition of the histone demethylase KDM4B leads to activation of KDM1A, attenuates bacterial-induced pro-inflammatory cytokine release, and reduces osteoclastogenesis, Epigenetics, August 2018, Taylor & Francis,
DOI: 10.1080/15592294.2018.1481703.
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