All Stories

  1. KDM4B inhibition reduces inflammatory cytokines, and thus inflammation and bone destruction.

    Article • Epigenetics, August 2018, Taylor & Francis

    Prof. Patrick M. Woster

  2. Cyclic peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis

    Article • European Journal of Medicinal Chemistry, March 2018, Elsevier

    Prof. Patrick M. Woster

  3. Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites

    Article • Bioorganic & Medicinal Chemistry, August 2015, Elsevier

    Professor Lyn-Marie Birkholtz, Prof. Patrick M. Woster

  4. Structure–activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures

    Article • Bioorganic & Medicinal Chemistry, April 2015, Elsevier

    Prof. Patrick M. Woster

  5. Transcriptional Activity of the Islet β Cell Factor Pdx1 Is Augmented by Lysine Methylation Catalyzed by the Methyltransferase Set7/9

    Article • Journal of Biological Chemistry, February 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof. Patrick M. Woster

  6. Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group

    Article • MedChemComm, January 2015, Royal Society of Chemistry

    Prof. Patrick M. Woster

  7. Epigenetics: Novel Therapeutics Targeting Epigenetics

    Article • Journal of Medicinal Chemistry, December 2014, American Chemical Society (ACS)

    Prof. Patrick M. Woster

  8. Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase

    Article • Oncogene, September 2014, Springer Science + Business Media

    Prof. Patrick M. Woster

  9. P1 and P1′ para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: Structure-based virtual screening of extended lopinavir analogs against multi-drug resistant HIV-1 protease

    Article • Journal of Molecular Graphics and Modelling, February 2014, Elsevier

    Prof. Patrick M. Woster

  10. 3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors

    Article • MedChemComm, January 2014, Royal Society of Chemistry

    Prof. Patrick M. Woster

  11. Design of small molecule epigenetic modulators

    Article • Bioorganic & Medicinal Chemistry Letters, January 2014, Elsevier

    Prof. Patrick M. Woster

  12. Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease

    Article • Bioorganic & Medicinal Chemistry, December 2013, Elsevier

    Prof. Patrick M. Woster

  13. Synthesis and Evaluation of Novel Cyclic Peptide Inhibitors of Lysine-Specific Demethylase 1

    Article • ACS Medicinal Chemistry Letters, November 2013, American Chemical Society (ACS)

    Prof. Patrick M. Woster

  14. Histone Deacetylase Inhibition Overcomes Drug Resistance through a miRNA-Dependent Mechanism

    Article • Molecular Cancer Therapeutics, August 2013, American Association for Cancer Research (AACR)

    Prof. Patrick M. Woster

  15. Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites

    Article • Amino Acids, July 2013, Springer Science + Business Media

    Prof. Patrick M. Woster

  16. 99 Polyamines Mediate Helicobacter priori-Induced Gastric Carcinogenesis in Gerbils

    Article • Gastroenterology, May 2013, Elsevier

    Prof. Patrick M. Woster

  17. The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines

    Article • Amino Acids, March 2013, Springer Science + Business Media

    Prof. Patrick M. Woster

  18. Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner

    Article • Biochemical Journal, January 2013, Portland Press Ltd.

    Prof. Patrick M. Woster

  19. Polyamines and cancer: implications for chemotherapy and chemoprevention

    Article • Expert Reviews in Molecular Medicine, January 2013, Cambridge University Press

    Prof. Patrick M. Woster

  20. Low Molecular Weight Amidoximes that Act as Potent Inhibitors of Lysine-Specific Demethylase 1

    Article • Journal of Medicinal Chemistry, September 2012, American Chemical Society (ACS)

    Prof. Patrick M. Woster

  21. Polyamine Drug Discovery. Edited by Patrick Woster and Robert A. Casero, Jr.

    Article • June 2012, Wiley

    Prof. Patrick M. Woster

  22. Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds

    Article • May 2012, Elsevier

    Prof. Patrick M. Woster

  23. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

    Article • Nature Medicine, March 2012, Springer Science + Business Media

    Prof. Patrick M. Woster

  24. Novel Pt(II) and Pd(II) complexes with polyamine analogues: Synthesis and vibrational analysis

    Article • Journal of Inorganic Biochemistry, March 2012, Elsevier

    Professor Maria Paula M Marques, Prof. Patrick M. Woster

  25. Polyamine-based small molecule epigenetic modulators

    Article • MedChemComm, January 2012, Royal Society of Chemistry

    Prof. Patrick M. Woster

  26. Polyamine Drug Discovery: Synthetic Approaches to Therapeutic Modulators of Polyamine Metabolism

    Article • November 2011, Royal Society of Chemistry

    Prof. Patrick M. Woster

  27. The Design and Development of Polyamine-Based Analogs with Epigenetic Targets

    Article • November 2011, Royal Society of Chemistry

    Prof. Patrick M. Woster

  28. Symmetrical- and Unsymmetrical Terminally Alkylated Polyamines

    Article • November 2011, Royal Society of Chemistry

    Prof. Patrick M. Woster

  29. Polyamine Drug Discovery

    Article • November 2011, Royal Society of Chemistry

    Prof. Patrick M. Woster

  30. Alternative Spermidine Biosynthetic Route Is Critical for Growth ofCampylobacter jejuniand Is the Dominant Polyamine Pathway in Human Gut Microbiota

    Article • Journal of Biological Chemistry, October 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof. Patrick M. Woster

  31. Discovery of Novel Alkylated (bis)Urea and (bis)Thiourea Polyamine Analogues with Potent Antimalarial Activities

    Article • Journal of Medicinal Chemistry, October 2011, American Chemical Society (ACS)

    Professor Lyn-Marie Birkholtz, Prof. Patrick M. Woster

  32. Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis -induced colon tumorigenesis

    Article • Proceedings of the National Academy of Sciences, August 2011, Proceedings of the National Academy of Sciences

    Prof. Patrick M. Woster

  33. Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N 1, N 11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells

    Article • Amino Acids, August 2011, Springer Science + Business Media

    Prof. Patrick M. Woster

  34. Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells

    Article • Amino Acids, July 2011, Springer Science + Business Media

    Prof. Patrick M. Woster

  35. Use of Polyamine Derivatives as Selective Histone Deacetylase Inhibitors

    Article • January 2011, Springer Science + Business Media

    Prof. Patrick M. Woster

  36. Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm

    Article • BMC Cancer, October 2010, Springer Science + Business Media

    Dr Emiliano Grillo, Full Professor of Biochemistry Fabio Polticelli, Prof. Patrick M. Woster

  37. Antiprotozoal/Antiparasitic Agents

    Article • September 2010, Wiley

    Prof. Patrick M. Woster

  38. (Bis)urea and (Bis)thiourea Inhibitors of Lysine-Specific Demethylase 1 as Epigenetic Modulators

    Article • Journal of Medicinal Chemistry, July 2010, American Chemical Society (ACS)

    Prof. Patrick M. Woster

  39. Mechanism-Based Inhibitors of the Aspartyl Protease Plasmepsin II as Potential Antimalarial Agents

    Article • Journal of Medicinal Chemistry, May 2010, American Chemical Society (ACS)

    Prof. Patrick M. Woster

  40. ChemInform Abstract: Novel Alkylpolyamine Analogues that Possess Both Antitrypanosomal and Antimicrosporidial Activity.

    Article • ChemInform, May 2010, Wiley

    Prof. Patrick M. Woster

  41. Suppression of Exogenous Gene Expression by Spermidine/SpermineN1-Acetyltransferase 1 (SSAT1) Cotransfection

    Article • Journal of Biological Chemistry, March 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof. Patrick M. Woster

  42. Epigenetic Targets and Cancer Drug Discovery

    Article • January 2010, Elsevier

    Prof. Patrick M. Woster

  43. Foreword: American Chemical Society Division of Medicinal Chemistry. Celebrating 100 Years of Excellence

    Article • Journal of Medicinal Chemistry, December 2009, American Chemical Society (ACS)

    Prof. Patrick M. Woster

  44. Novel Oligoamine Analogues Inhibit Lysine-Specific Demethylase 1 and Induce Reexpression of Epigenetically Silenced Genes

    Article • Clinical Cancer Research, November 2009, American Association for Cancer Research (AACR)

    Prof. Patrick M. Woster

  45. Design of polyamine-based therapeutic agents: new targets and new directions

    Article • Essays in Biochemistry, October 2009, Portland Press Ltd.

    Prof. Patrick M. Woster

  46. Polyamine analogues targeting epigenetic gene regulation

    Article • Essays in Biochemistry, October 2009, Portland Press Ltd.

    Prof. Patrick M. Woster

  47. A Small Molecule Polyamine Oxidase Inhibitor Blocks Androgen-Induced Oxidative Stress and Delays Prostate Cancer Progression in the Transgenic Adenocarcinoma of the Mouse Prostate Model

    Article • Cancer Research, September 2009, American Association for Cancer Research (AACR)

    Prof. Patrick M. Woster

  48. The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines

    Article • Cancer Chemotherapy and Pharmacology, August 2009, Springer Science + Business Media

    Prof. Patrick M. Woster

  49. Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts

    Article • Biochemical Journal, August 2009, Portland Press Ltd.

    Prof. Patrick M. Woster

  50. Recent Advances in the Development of Polyamine Analogues as Antitumor Agents§

    Article • Journal of Medicinal Chemistry, August 2009, American Chemical Society (ACS)

    Prof. Patrick M. Woster

  51. A novel histone deacetylase inhibitor prevents IL-1β induced metabolic dysfunction in pancreatic β-cells

    Article • Journal of Cellular and Molecular Medicine, August 2009, Wiley

    Prof. Patrick M. Woster

  52. A novel histone deacetylase inhibitor prevents IL-1β induced metabolic dysfunction in pancreatic β-cells

    Article • Journal of Cellular and Molecular Medicine, August 2009, Wiley

    Prof. Patrick M. Woster

  53. Metabolism of an Alkyl Polyamine Analog by a Polyamine Oxidase from the Microsporidian Encephalitozoon cuniculi

    Article • Antimicrobial Agents and Chemotherapy, February 2009, ASM Journals

    Prof. Patrick M. Woster

  54. Elevated Ornithine Decarboxylase Levels Activate Ataxia Telangiectasia Mutated-DNA Damage Signaling in Normal Keratinocytes

    Article • Cancer Research, April 2008, American Association for Cancer Research (AACR)

    Prof. Patrick M. Woster

  55. Polyaminohydroxamic Acids and Polyaminobenzamides as Isoform Selective Histone Deacetylase Inhibitors§

    Article • Journal of Medicinal Chemistry, April 2008, American Chemical Society (ACS)

    Prof. Patrick M. Woster

  56. Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis

    Article • Carcinogenesis, September 2007, Oxford University Press (OUP)

    Prof. Patrick M. Woster

  57. Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes

    Article • Proceedings of the National Academy of Sciences, May 2007, Proceedings of the National Academy of Sciences

    Prof. Patrick M. Woster

  58. Polyamine-based analogues as biochemical probes and potential therapeutics

    Article • Biochemical Society Transactions, April 2007, Portland Press Ltd.

    Prof. Patrick M. Woster

  59. Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide

    Article • Amino Acids, March 2007, Springer Science + Business Media

    Prof. Patrick M. Woster

  60. Antiprotozoal Agents (African Trypanosomiasis, Chagas Disease, and Leishmaniasis)

    Article • January 2007, Elsevier

    Prof. Patrick M. Woster

  61. Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity

    Article • Bioorganic & Medicinal Chemistry Letters, June 2006, Elsevier

    Prof. Patrick M. Woster

  62. Effect of pro-inflammatory cytokines on the toxicity of the arylhydroxylamine metabolites of sulphamethoxazole and dapsone in normal human keratinocytes

    Article • Toxicology, February 2006, Elsevier

    Prof. Patrick M. Woster

  63. Spermine Oxidase SMO(PAOh1), NotN1-Acetylpolyamine Oxidase PAO, Is the Primary Source of Cytotoxic H2O2in Polyamine Analogue-treated Human Breast Cancer Cell Lines

    Article • Journal of Biological Chemistry, October 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof. Patrick M. Woster

  64. Alkyl-Substituted Polyaminohydroxamic Acids:  A Novel Class of Targeted Histone Deacetylase Inhibitors

    Article • Journal of Medicinal Chemistry, October 2005, American Chemical Society (ACS)

    Prof. Patrick M. Woster

  65. Role of p53/p21Waf1/Cip1 in the regulation of polyamine analogue-induced growth inhibition and cell death in human breast cancer cells

    Article • Cancer Biology & Therapy, September 2005, Taylor & Francis

    Prof. Patrick M. Woster

  66. Reactive oxygen species generation and its role in the differential cytotoxicity of the arylhydroxylamine metabolites of sulfamethoxazole and dapsone in normal human epidermal keratinocytes

    Article • Biochemical Pharmacology, July 2005, Elsevier

    Prof. Patrick M. Woster

  67. A Charge-Deficient Analogue of Spermine with Chelating Properties

    Article • Russian Journal of Bioorganic Chemistry, May 2005, Springer Science + Business Media

    Prof. Patrick M. Woster

  68. Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity

    Article • Cancer Chemotherapy and Pharmacology, March 2005, Springer Science + Business Media

    Prof. Patrick M. Woster

  69. Induction of human spermine oxidase SMO(PAOh1) is regulated at the levels of new mRNA synthesis, mRNA stabilization and newly synthesized protein

    Article • Biochemical Journal, March 2005, Portland Press Ltd.

    Prof. Patrick M. Woster

  70. Bergamottin contribution to the grapefruit juice?felodipine interaction and disposition in humans

    Article • December 2004, Springer Science + Business Media

    Prof. Patrick M. Woster

  71. Fundamentals of Medicinal Chemistry By Gareth Thomas. John Wiley and Sons, Ltd., West Sussex, U.K.. 2003. xv + 285 pp. 19 × 24.5 cm. ISBN 0-4708-4307-1. $30.00.

    Article • Journal of Medicinal Chemistry, July 2004, American Chemical Society (ACS)

    Prof. Patrick M. Woster

  72. Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells

    Article • Cancer Chemotherapy and Pharmacology, November 2003, Springer Science + Business Media

    Prof. Patrick M. Woster

  73. Properties of purified recombinant human polyamine oxidase, PAOh1/SMO

    Article • May 2003, Elsevier

    Prof. Patrick M. Woster

  74. The role of polyamine catabolism in anti-tumour drug response

    Article • Biochemical Society Transactions, April 2003, Portland Press Ltd.

    Prof. Patrick M. Woster

  75. The Activator-Binding Site of Onchocerca volvulus S-Adenosylmethionine Decarboxylase, a Potential Drug Target

    Article • January 2003, De Gruyter

    Prof. Patrick M. Woster

  76. Chapter 21. New therapies for malaria

    Article • January 2003, Elsevier

    Prof. Patrick M. Woster

  77. Induction of apoptosis in human leukaemic cells by IPENSpm, a novel polyamine analogue and anti-metabolite

    Article • Biochemical Journal, October 2002, Portland Press Ltd.

    Prof. Patrick M. Woster

  78. Cloning and characterization of the mouse polyamine-modulatedfactor-1 (mPMF-1) gene: an alternatively spliced homologue of the human transcription factor

    Article • October 2001, Portland Press Ltd.

    Prof. Patrick M. Woster

  79. Cloning and characterization of the mouse polyamine-modulatedfactor-1 (mPMF-1) gene: an alternatively spliced homologue of the human transcription factor

    Article • Biochemical Journal, October 2001, Portland Press Ltd.

    Prof. Patrick M. Woster

  80. Novel Alkylpolyamine Analogues that Possess Both Antitrypanosomal and Antimicrosporidial Activity

    Article • Bioorganic & Medicinal Chemistry Letters, June 2001, Elsevier

    Prof. Patrick M. Woster

  81. Terminally Alkylated Polyamine Analogues as Chemotherapeutic Agents

    Article • Journal of Medicinal Chemistry, January 2001, American Chemical Society (ACS)

    Prof. Patrick M. Woster

  82. A Role for Bioactivation and Covalent Binding within Epidermal Keratinocytes in Sulfonamide-Induced Cutaneous Drug Reactions

    Article • June 2000, Elsevier

    Prof. Patrick M. Woster

  83. Molecular basis for the polyamine-OmpF porin interactions: inhibitor and mutant studies 1 1Edited by G. von Heijne

    Article • Journal of Molecular Biology, April 2000, Elsevier

    Ramkumar Iyer, Prof. Patrick M. Woster

  84. Erratum: Nairn LM, Lindsay GS, Woster PM, and Wallace HM (2000): Cytotoxicity of novel unsymmetrically substituted inhibitors of polyamine biosynthesis in human cancer cells. J. Cell Physiol 182:209-213.

    Article • Journal of Cellular Physiology, April 2000, Wiley

    Prof. Patrick M. Woster

  85. Cytotoxicity of novel unsymmetrically substituted inhibitors of polyamine biosynthesis in human cancer cells

    Article • Journal of Cellular Physiology, February 2000, Wiley

    Prof. Patrick M. Woster

  86. 1-(N-Alkylamino)-11-(N-ethylamino)-4,8-diazaundecanes:  Simple Synthetic Polyamine Analogues That Differentially Alter Tubulin Polymerization

    Article • Journal of Medicinal Chemistry, March 1999, American Chemical Society (ACS)

    Prof. Patrick M. Woster

  87. 6 ́,7 ́-Dihydroxybergamottin in grapefruit juice and Seville orange juice: Effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein

    Article • March 1999, Springer Science + Business Media

    Prof. Patrick M. Woster

  88. Clinical aspects of cell death in breast cancer: the polyamine pathway as a new target for treatment

    Article • Endocrine Related Cancer, March 1999, Bioscientifica

    Prof. Patrick M. Woster

  89. 82 Comparison of poryamine analogue toxicity in two cell lines (HL-60 & MCF-7)

    Article • Biochemical Society Transactions, November 1998, Portland Press Ltd.

    Prof. Patrick M. Woster

  90. The natural polyamine spermine functions directly as a free radical scavenger

    Article • Proceedings of the National Academy of Sciences, September 1998, Proceedings of the National Academy of Sciences

    Prof. Patrick M. Woster

  91. Comparison of the In Vitro Cytotoxicity of Hydroxylamine Metabolites of Sulfamethoxazole and Dapsone

    Article • Biochemical Pharmacology, March 1998, Elsevier

    Prof. Patrick M. Woster

  92. Structural Specificity of Polyamines and Polyamine Analogues in the Protection of DNA from Strand Breaks Induced by Reactive Oxygen Species

    Article • March 1998, Elsevier

    Prof. Patrick M. Woster

  93. Synthesis of protected allylic amines via palladium(0)-catalyzed amination of allylic acetates

    Article • Tetrahedron Letters, March 1998, Elsevier

    Prof. Patrick M. Woster

  94. The role of polyamine catabolism in polyamine analogue-induced programmed cell death

    Article • Proceedings of the National Academy of Sciences, October 1997, Proceedings of the National Academy of Sciences

    Prof. Patrick M. Woster

  95. Synthesis and biological evaluation of 6′,7′-dihydroxybergamottin (6,7-DHB), a naturally occurring inhibitor of cytochrome P450 3A4

    Article • Bioorganic & Medicinal Chemistry Letters, October 1997, Elsevier

    Prof. Patrick M. Woster

  96. Structural comparison of alkylpolyamine analogues with potent in vitro antitumor or antiparasitic activity

    Article • Bioorganic & Medicinal Chemistry Letters, November 1996, Elsevier

    Prof. Patrick M. Woster

  97. Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase

    Article • Bioorganic & Medicinal Chemistry, June 1996, Elsevier

    Prof. Patrick M. Woster

  98. Photoaffinity Labeling of a Cell Surface Polyamine Binding Protein

    Article • Journal of Biological Chemistry, December 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof. Patrick M. Woster

  99. S-(5'-Deoxy-5'-adenosyl)-1-aminoxy-4-(methylsulfonio)-2-cyclopentene (AdoMao): An Irreversible Inhibitor of S-Adenosylmethionine Decarboxylase with Potent in Vitro Antitrypanosomal Activity

    Article • Journal of Medicinal Chemistry, May 1995, American Chemical Society (ACS)

    Prof. Patrick M. Woster

  100. Irreversible inhibition of human S -adenosylmethionine decarboxylase by the pure diastereomeric forms of S -(5′-deoxy-5′-adenosyl)-1-ammonio-4-methylsulfonio-2-cyclopentene (AdoMac)

    Article • Biochemical Pharmacology, April 1995, Elsevier

    Prof. Patrick M. Woster

  101. Growth and biochemical effects of unsymmetrically substituted polyamine analogues in human lung tumor cells 1

    Article • Cancer Chemotherapy and Pharmacology, January 1995, Springer Science + Business Media

    Prof. Patrick M. Woster

  102. Dapsone-Induced Hematologic Toxicity: Comparison of the Methemoglobin-Forming Ability of Hydroxylamine Metabolites of Dapsone in Rat and Human Blood

    Article • December 1994, Elsevier

    Prof. Patrick M. Woster

  103. α-cyano-substituted analogoues of decarboxylated S-adenosylmethionine as enzyme activated, irreversible inhibitors of S-adenosylmethionine decarboxylase

    Article • Bioorganic & Medicinal Chemistry Letters, December 1993, Elsevier

    Prof. Patrick M. Woster

  104. Preparation of the pure diastereomeric forms of S- (5′-deoxy-5′-adenosyl)-1-ammonio-4-methylsulfonio-2- cyclopentene and their evaluation as irreversible inhibitors of S-adenosylmethionine decarboxylase from Escherichia coli

    Article • Bioorganic & Medicinal Chemistry, November 1993, Elsevier

    Prof. Patrick M. Woster

  105. Synthesis and evaluation of unsymmetrically substituted polyamine analogs as modulators of human spermidine/spermine-N1-acetyltransferase (SSAT) and as potential antitumor agents

    Article • Journal of Medicinal Chemistry, October 1993, American Chemical Society (ACS)

    Prof. Patrick M. Woster

  106. Restricted rotation analogs of S-adenosylmethionine: synthesis, evaluation as inhibitors of S-adenosylmethionine decarboxylase, and potential use as selective antitrypanosomal agents

    Article • Bioorganic & Medicinal Chemistry Letters, February 1993, Elsevier

    Prof. Patrick M. Woster

  107. S-(5'-Deoxy-5'-adenosyl)-1-ammonio-4-(methylsulfonio)-2-cyclopentene: a potent, enzyme-activated irreversible inhibitor of S-adenosylmethionine decarboxylase

    Article • Journal of Medicinal Chemistry, August 1992, American Chemical Society (ACS)

    Prof. Patrick M. Woster

  108. Restricted rotation analogs of decarboxylated S-adenosylmethionine as inhibitors of polyamine biosynthesis.

    Article • Bioorganic & Medicinal Chemistry Letters, January 1991, Elsevier

    Prof. Patrick M. Woster

  109. Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells

    Article • Biochemistry, October 1989, American Chemical Society (ACS)

    Prof. Patrick M. Woster

  110. Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase

    Article • Journal of Medicinal Chemistry, June 1989, American Chemical Society (ACS)

    Prof. Patrick M. Woster

  111. Synthesis and biological evaluation of cyclic analogs of l-carnitine as potential agents in the treatment of myocardial ischemia

    Article • Journal of Medicinal Chemistry, May 1986, American Chemical Society (ACS)

    Prof. Patrick M. Woster

  112. Polyamine Structure and Synthetic Analogs

    Article • Springer Science + Business Media

    Prof. Patrick M. Woster