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GITR is a receptor expressed at high levels by regulatory T cells (Tregs) and activated conventional T cells. The review describes the effects of GITR triggering in physiology and diseases. GITR triggering by antibodies causes death by ADCC of Tregs present inside the tumor and stimulate CD8+ cells.
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This page is a summary of: Glucocorticoid-induced TNFR-related gene (GITR) as a therapeutic target for immunotherapy, Expert Opinion on Therapeutic Targets, August 2018, Taylor & Francis,
DOI: 10.1080/14728222.2018.1512588.
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