What is it about?
A protein ArfGAP (AGAP1) which regulates actin-dependent processes in the cell binds to and turns on a protein called Kif2A. Kif2A remodels the microtubule cytoskeleton. This activity links the remodeling of the two key cytoskeletal networks together so they can be coordinately regulated.
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Why is it important?
This study directly connects microtubule remodeling to actin remodeling and trafficking, which has the potential to explain how subcellular patterns are established.
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This page is a summary of: Direct Functional Interaction of the Kinesin-13 Family Membrane Kinesin-like Protein 2A (Kif2A) and Arf GAP with GTP-binding Protein-like, Ankyrin Repeats and PH Domains1 (AGAP1), Journal of Biological Chemistry, August 2016, American Society for Biochemistry & Molecular Biology (ASBMB),
DOI: 10.1074/jbc.m116.732479.
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