All Stories

  1. β-Tubulin carboxy-terminal tails exhibit isotype-specific effects on microtubule dynamics in human gene-edited cells

    Article • Life Science Alliance, April 2018, Life Science Alliance, LLC

    Linda Wordeman

  2. Corrigendum: The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation

    Article • Nature Cell Biology, May 2017, Springer Science + Business Media

    Linda Wordeman

  3. Arf GAPs and molecular motors

    Article • Small GTPases, April 2017, Taylor & Francis

    Linda Wordeman

  4. Motor tethers centrosomes during interphase

    Article • Nature, March 2017, Nature

    Linda Wordeman

  5. Direct functional interaction of the kinesin-13 family member kinesin-like protein 2A (Kif2A) and Arf GAP with GTP-binding protein-like, ankyrin repeats and PH domains 1 (AGAP1).

    Article • Journal of Biological Chemistry, December 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Linda Wordeman

  6. An AGAP1Kif2A Functional Complex

    Article • Journal of Biological Chemistry, August 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Linda Wordeman

  7. ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme

    Article • Molecular Cancer Therapeutics, June 2016, American Association for Cancer Research (AACR)

    Linda Wordeman

  8. Molecular insight into the regulation and function of MCAK

    Article • Critical Reviews in Biochemistry and Molecular Biology, May 2016, Taylor & Francis

    Linda Wordeman

  9. Oxidative stress decreases microtubule growth and stability in ventricular myocytes

    Article • Journal of Molecular and Cellular Cardiology, April 2016, Elsevier

    Linda Wordeman, Distinguished Professor L. Fernando Santana

  10. Divergent microtubule assembly rates after short- versus long-term loss of end-modulating kinesins

    Article • Molecular Biology of the Cell, February 2016, American Society for Cell Biology (ASCB)

    Linda Wordeman

  11. Oxidative Stress in Myocardial Infarction Disrupts Microtubule Trafficking, Reducing Transient Outward Current Density

    Article • Biophysical Journal, February 2016, Elsevier

    Linda Wordeman

  12. Revisiting Actin's role in early centrosome separation

    Article • Cell Cycle, December 2015, Taylor & Francis

    Linda Wordeman

  13. ATPS-06BRAIN-PENETRANT ALKYLINDOLE COMPOUNDS PROMOTE APOPTOSIS IN GLIOMA CELLS THROUGH MICROTUBULE DESTABILIZATION

    Article • Neuro-Oncology, November 2015, Oxford University Press (OUP)

    Linda Wordeman

  14. A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells

    Article • eLife, September 2015, eLife

    Linda Wordeman, Distinguished Professor L. Fernando Santana

  15. HX-MS2 for high performance conformational analysis of complex protein states

    Article • Protein Science, May 2015, Wiley

    Linda Wordeman

  16. Mitosis, microtubule dynamics and the evolution of kinesins

    Article • Experimental Cell Research, May 2015, Elsevier

    Linda Wordeman

  17. Mass Spec Studio for Integrative Structural Biology

    Article • Structure, October 2014, Elsevier

    Linda Wordeman, Dr. Alexandre M.J.J. Bonvin

  18. Nucleotide Exchange in Dimeric MCAK Induces Longitudinal and Lateral Stress at Microtubule Ends to Support Depolymerization

    Article • Structure, August 2014, Elsevier

    Linda Wordeman

  19. Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells

    Article • Nature, June 2014, Nature

    Linda Wordeman

  20. Rapid Measurement of Mitotic Spindle Orientation in Cultured Mammalian Cells

    Article • January 2014, Springer Science + Business Media

    Linda Wordeman

  21. Roles for focal adhesion kinase (FAK) in blastomere abscission and vesicle trafficking during cleavage in the sea urchin embryo

    Article • Mechanisms of Development, April 2013, Elsevier

    Linda Wordeman

  22. Kinesins as Microtubule Disassembly Enzymes

    Article • January 2013, Elsevier

    Linda Wordeman

  23. Gravin Is a Transitory Effector of Polo-like Kinase 1 during Cell Division

    Article • Molecular Cell, November 2012, Elsevier

    Linda Wordeman

  24. FAM123A Binds to Microtubules and Inhibits the Guanine Nucleotide Exchange Factor ARHGEF2 to Decrease Actomyosin Contractility

    Article • Science Signaling, September 2012, American Association for the Advancement of Science

    Linda Wordeman

  25. Kif18A and Chromokinesins Confine Centromere Movements via Microtubule Growth Suppression and Spatial Control of Kinetochore Tension

    Article • Developmental Cell, May 2012, Elsevier

    Linda Wordeman

  26. MCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment

    Article • Journal of Cell Biology, April 2012, Rockefeller University Press

    Linda Wordeman

  27. The Kinesin Superfamily

    Article • January 2012, Springer Science + Business Media

    Linda Wordeman

  28. Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target

    Article • Oncotarget, December 2011, Impact Journals, LLC

    Linda Wordeman

  29. AKAP220 Protein Organizes Signaling Elements That Impact Cell Migration

    Article • Journal of Biological Chemistry, September 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Linda Wordeman

  30. A Tethering Mechanism Controls the Processivity and Kinetochore-Microtubule Plus-End Enrichment of the Kinesin-8 Kif18A

    Article • Molecular Cell, September 2011, Elsevier

    Linda Wordeman

  31. Mip1 associates with both the Mps1 kinase and actin, and is required for cell cortex stability and anaphase spindle positioning

    Article • Cell Cycle, March 2011, Taylor & Francis

    Linda Wordeman

  32. In Vitro Reconstitution of the Functional Interplay between MCAK and EB3 at Microtubule Plus Ends

    Article • Current Biology, October 2010, Elsevier

    Linda Wordeman, susana Gouveia

  33. Long astral microtubules uncouple mitotic spindles from the cytokinetic furrow

    Article • Journal of Cell Biology, July 2010, Rockefeller University Press

    Linda Wordeman

  34. Session 68: Oocyte Maturation

    Article • Human Reproduction, June 2010, Oxford University Press (OUP)

    Linda Wordeman

  35. Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B

    Article • Journal of Cell Biology, May 2010, Rockefeller University Press

    Linda Wordeman

  36. How kinesin motor proteins drive mitotic spindle function: Lessons from molecular assays

    Article • Seminars in Cell and Developmental Biology, May 2010, Elsevier

    Linda Wordeman

  37. MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes

    Article • Molecular Human Reproduction, April 2010, Oxford University Press (OUP)

    Linda Wordeman

  38. Reconstitution and Functional Analysis of Kinetochore Subcomplexes

    Article • January 2010, Elsevier

    Linda Wordeman

  39. Catalysis of the microtubule on-rate is the major parameter regulating the depolymerase activity of MCAK

    Article • Nature Structural & Molecular Biology, December 2009, Nature

    Linda Wordeman

  40. Microtubule Length Control, a Team Sport?

    Article • Developmental Cell, October 2009, Elsevier

    Linda Wordeman

  41. Motor-dependent microtubule disassembly driven by tubulin tyrosination

    Article • Journal of Cell Biology, June 2009, Rockefeller University Press

    Linda Wordeman

  42. TIP150 interacts with and targets MCAK at the microtubule plus ends

    Article • EMBO Reports, June 2009, EMBO

    Linda Wordeman

  43. A new model for binding of kinesin 13 to curved microtubule protofilaments

    Article • Journal of Cell Biology, March 2009, Rockefeller University Press

    Linda Wordeman

  44. The Ndc80 Kinetochore Complex Forms Load-Bearing Attachments to Dynamic Microtubule Tips via Biased Diffusion

    Article • Cell, March 2009, Elsevier

    Linda Wordeman

  45. The diffusive interaction of microtubule binding proteins

    Article • Current Opinion in Cell Biology, February 2009, Elsevier

    Linda Wordeman

  46. Reconstitution Of Microtubule-driven Movement and Force Production by the Ndc80 Kinetochore Complex

    Article • Biophysical Journal, February 2009, Elsevier

    Linda Wordeman

  47. A kinesin-13 mutant catalytically depolymerizes microtubules in ADP

    Article • Journal of Cell Biology, November 2008, Rockefeller University Press

    Linda Wordeman

  48. Phosphoregulation and depolymerization-driven movement of the Dam1 complex do not require ring formation

    Article • Nature, March 2008, Nature

    Linda Wordeman

  49. The Kinesin-8 Motor Kif18A Suppresses Kinetochore Movements to Control Mitotic Chromosome Alignment

    Article • Developmental Cell, February 2008, Elsevier

    Linda Wordeman

  50. MCAK facilitates chromosome movement by promoting kinetochore microtubule turnover

    Article • Journal of Cell Biology, November 2007, Rockefeller University Press

    Linda Wordeman

  51. Rings, bracelets, sleeves, and chevrons: new structures of kinetochore proteins

    Article • Trends in Cell Biology, August 2007, Elsevier

    Linda Wordeman

  52. The Kinesin-13 Proteins Kif2a, Kif2b, and Kif2c/MCAK Have Distinct Roles during Mitosis in Human Cells

    Article • Molecular Biology of the Cell, May 2007, American Society for Cell Biology (ASCB)

    Linda Wordeman

  53. Chromosome Congression: The Kinesin-8-Step Path to Alignment

    Article • Current Biology, May 2007, Elsevier

    Linda Wordeman

  54. In Vitro and In Vivo Analysis of Microtubule-Destabilizing Kinesins

    Article • January 2007, Springer Science + Business Media

    Linda Wordeman

  55. Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends

    Article • Journal of Cell Biology, September 2006, Rockefeller University Press

    Linda Wordeman

  56. The Role of the Kinesin-13 Neck in Microtubule Depolymerization

    Article • Cell Cycle, August 2006, Taylor & Francis

    Professor Carolyn A Moores, Linda Wordeman

  57. A Perikinetochoric Ring Defined by MCAK and Aurora-B as a Novel Centromere Domain

    Article • PLoS Genetics, January 2006, PLOS

    Linda Wordeman

  58. Kinesin-2 is a Motor for Late Endosomes and Lysosomes

    Article • Traffic, October 2005, Wiley

    Dr. Tobias Stauber, Linda Wordeman

  59. MCAK associates with the tips of polymerizing microtubules

    Article • Journal of Cell Biology, May 2005, Rockefeller University Press

    Linda Wordeman

  60. Microtubule-depolymerizing kinesins

    Article • Current Opinion in Cell Biology, February 2005, Elsevier

    Linda Wordeman

  61. A Perikinetochoric Ring Defined by MCAK as a New Centromere Domain in Meiosis

    Article • PLoS Genetics, January 2005, PLOS

    Linda Wordeman

  62. C-terminus of mitotic centromere-associated kinesin (MCAK) inhibits its lattice-stimulated ATPase activity

    Article • Biochemical Journal, October 2004, Portland Press Ltd.

    Linda Wordeman

  63. A standardized kinesin nomenclature: Table I.

    Article • Journal of Cell Biology, October 2004, Rockefeller University Press

    Linda Wordeman

  64. The mechanism, function and regulation of depolymerizing kinesins during mitosis

    Article • Trends in Cell Biology, October 2004, Elsevier

    Linda Wordeman

  65. MCAK, a Kin I kinesin, increases the catastrophe frequency of steady-state HeLa cell microtubules in an ATP-dependent manner in vitro

    Article • FEBS Letters, July 2004, Wiley

    Linda Wordeman

  66. Aurora B Regulates MCAK at the Mitotic Centromere

    Article • Developmental Cell, February 2004, Elsevier

    Linda Wordeman

  67. Breathing down the neck of Unc104: Figure 1.

    Article • Journal of Cell Biology, November 2003, Rockefeller University Press

    Linda Wordeman

  68. Unconventional Motoring: An Overview of the Kin C and Kin I Kinesins

    Article • Traffic, May 2003, Wiley

    Linda Wordeman

  69. The Kinesin-Related Protein MCAK Is a Microtubule Depolymerase that Forms an ATP-Hydrolyzing Complex at Microtubule Ends

    Article • Molecular Cell, February 2003, Elsevier

    Linda Wordeman

  70. K-loop insertion restores microtubule depolymerizing activity of a “neckless” MCAK mutant

    Article • Journal of Cell Biology, November 2002, Rockefeller University Press

    Linda Wordeman

  71. Molecular Dissection of the Microtubule Depolymerizing Activity of Mitotic Centromere-associated Kinesin

    Article • Journal of Biological Chemistry, July 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Linda Wordeman

  72. Expression Cloning with Pan Kinesin Antibodies

    Article • January 2001, Springer Science + Business Media

    Linda Wordeman

  73. Expression and Partial Characterization of Kinesin-related Proteins in Differentiating and Adult Skeletal Muscle

    Article • Molecular Biology of the Cell, December 2000, American Society for Cell Biology (ASCB)

    Linda Wordeman

  74. Green fluorescent protein

    Article • Cell Biology International, July 1999, Wiley

    Linda Wordeman

  75. MUTATIONS IN THE ATP-BINDING DOMAIN AFFECT THE SUBCELLULAR DISTRIBUTION OF MITOTIC CENTROMERE-ASSOCIATED KINESIN (MCAK)

    Article • Cell Biology International, April 1999, Wiley

    Linda Wordeman

  76. The Kinetochore of Higher Eucaryotes: A Molecular View

    Article • January 1999, Elsevier

    Linda Wordeman

  77. Mitotic Centromere–associated Kinesin Is Important for Anaphase Chromosome Segregation

    Article • Journal of Cell Biology, August 1998, Rockefeller University Press

    Linda Wordeman

  78. Chapter 14 Using Antisense Technology to Study Mitosis

    Article • January 1998, Elsevier

    Linda Wordeman

  79. Disruption of CENP antigen function perturbs dynein anchoring to the mitotic kinetochore

    Article • Chromosoma, June 1996, Springer Science + Business Media

    Linda Wordeman

  80. Disruption of CENP antigen function perturbs dynein anchoring to the mitotic kinetochore

    Article • Chromosoma, June 1996, Springer Science + Business Media

    Linda Wordeman

  81. Mechanisms of chromosome segregation in metazoan cells

    Article • January 1995, Springer Science + Business Media

    Linda Wordeman

  82. Identification and partial characterization of mitotic centromere- associated kinesin, a kinesin-related protein that associates with centromeres during mitosis

    Article • Journal of Cell Biology, January 1995, Rockefeller University Press

    Linda Wordeman

  83. Inhibition of anaphase spindle elongation in vitro by a peptide antibody that recognizes kinesin motor domain.

    Article • Proceedings of the National Academy of Sciences, July 1993, Proceedings of the National Academy of Sciences

    Linda Wordeman

  84. Chemical subdomains within the kinetochore domain of isolated CHO mitotic chromosomes

    Article • Journal of Cell Biology, July 1991, Rockefeller University Press

    Linda Wordeman

  85. [39] Preparation of modified tubulins

    Article • January 1991, Elsevier

    Linda Wordeman

  86. Localization of cytoplasmic dynein to mitotic spindles and kinetochores

    Article • Nature, May 1990, Nature

    Linda Wordeman

  87. Cytokinesis by Furrowing in Diatoms

    Article • Annals of the New York Academy of Sciences, April 1990, Wiley

    Linda Wordeman

  88. Distribution of phosphorylated spindle-associated proteins in the diatomStephanopyxis turris

    Article • Cell Motility and the Cytoskeleton, January 1989, Wiley

    Linda Wordeman

  89. Reactivation of spindle elongation in vitro is correlated with the phosphorylation of a 205 kd spindle-associated protein

    Article • Cell, August 1987, Elsevier

    Linda Wordeman

  90. The distribution of cytoplasmic microtubules throughout the cell cycle of the centric diatom Stephanopyxis turris: their role in nuclear migration and positioning the mitotic spindle during cytokinesis

    Article • Journal of Cell Biology, May 1986, Rockefeller University Press

    Linda Wordeman

  91. Comparison of Spindle Elongation In Vivo and In Vitro in Stephanopyxis Turris

    Article • Journal of Cell Science, February 1986, The Company of Biologists

    Linda Wordeman

  92. Long Asters Rock The Spindle

    Article • SciVee, Inc

    Linda Wordeman

  93. In Vitro and In Vivo Analysis of Microtubule-Destabilizing Kinesins

    Article • Springer Science + Business Media

    Linda Wordeman