What is it about?
This study shows how the heart's energy levels change with each beat, revealing that the heart has less energy during rest than previously thought. It highlights two ways these energy levels can vary, which helps us understand how the heart stays healthy and what might go wrong in heart diseases.
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Why is it important?
This study is significant as it reshapes our understanding of cardiac energy dynamics. It reveals that heart muscle undergoes substantial fluctuations in one of its energy sources during each beat, and that its resting energy levels are lower than previously believed. These insights could lead to improved treatments for heart diseases by allowing us to better target cardiac energy management.
Read the Original
This page is a summary of: Fueling the heartbeat: Dynamic regulation of intracellular ATP during excitation–contraction coupling in ventricular myocytes, Proceedings of the National Academy of Sciences, June 2024, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2318535121.
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