All Stories

  1. How the Heart Generates and Uses Energy to Keep Beating

    Article • Proceedings of the National Academy of Sciences, June 2024, Proceedings of the National Academy of Sciences

    Distinguished Professor L. Fernando Santana

  2. Junctional sarcoplasmic reticulum motility in adult mouse ventricular myocytes

    Article • AJP Cell Physiology, March 2020, American Physiological Society

    Distinguished Professor L. Fernando Santana

  3. Kv2.1 channels play opposing roles in regulating membrane potential, Ca 2+ channel function, and myogenic tone in arterial smooth muscle

    Article • Proceedings of the National Academy of Sciences, February 2020, Proceedings of the National Academy of Sciences

    Distinguished Professor L. Fernando Santana

  4. Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons

    Article • eLife, October 2019, eLife

    Distinguished Professor L. Fernando Santana

  5. Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity

    Article • Journal of Cell Biology, October 2019, Rockefeller University Press

    Distinguished Professor L. Fernando Santana

  6. A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in mammalian brain neurons

    Article • eLife, September 2019, eLife

    Distinguished Professor L. Fernando Santana

  7. A stochastic model of ion channel cluster formation in the plasma membrane

    Article • Journal of General Physiology, August 2019, Rockefeller University Press

    Distinguished Professor L. Fernando Santana

  8. Adenylyl cyclase 5–generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia

    Article • Journal of Clinical Investigation, July 2019, American Society for Clinical Investigation

    Distinguished Professor L. Fernando Santana

  9. A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia

    Article • eLife, March 2019, eLife

    Distinguished Professor L. Fernando Santana

  10. BIN1 Induces the Formation of T-Tubules and Adult-Like Ca2+ Release Units in Developing Cardiomyocytes

    Article • Stem Cells, November 2018, Oxford University Press (OUP)

    Distinguished Professor L. Fernando Santana

  11. Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins

    Article • Proceedings of the National Academy of Sciences, November 2018, Proceedings of the National Academy of Sciences

    Distinguished Professor L. Fernando Santana

  12. Dynamic L-type CaV1.2 channel trafficking facilitates CaV1.2 clustering and cooperative gating

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, September 2018, Elsevier

    Distinguished Professor L. Fernando Santana

  13. A model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics

    Article • PLoS Computational Biology, January 2018, PLOS

    Distinguished Professor L. Fernando Santana

  14. Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes

    Article • Scientific Reports, October 2017, Springer Science + Business Media

    Distinguished Professor L. Fernando Santana

  15. A New Mutation in FIG4 Causes a Severe Form of CMT4J Involving TRPV4 in the Pathogenic Cascade

    Article • Journal of Neuropathology & Experimental Neurology, July 2017, Oxford University Press (OUP)

    Distinguished Professor L. Fernando Santana

  16. Proximal clustering between BK and CaV1.3 channels promotes functional coupling and BK channel activation at low voltage

    Article • eLife, June 2017, eLife

    Distinguished Professor L. Fernando Santana

  17. Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCα in arterial myocytes

    Article • Journal of General Physiology, May 2017, Rockefeller University Press

    Distinguished Professor L. Fernando Santana

  18. Calcium Channels in Vascular Smooth Muscle

    Article • January 2017, Elsevier

    Distinguished Professor L. Fernando Santana

  19. Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve

    Article • Cardiovascular Research, November 2016, European Society of Cardiology

    Distinguished Professor L. Fernando Santana

  20. AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K+ currents in ventricular myocytes following myocardial infarction

    Article • Cellular Signalling, July 2016, Elsevier

    Distinguished Professor L. Fernando Santana

  21. Ca2+ entry into neurons is facilitated by cooperative gating of clustered CaV1.3 channels

    Article • eLife, May 2016, eLife

    Distinguished Professor L. Fernando Santana

  22. Oxidative stress decreases microtubule growth and stability in ventricular myocytes

    Article • Journal of Molecular and Cellular Cardiology, April 2016, Elsevier

    Linda Wordeman, Distinguished Professor L. Fernando Santana

  23. A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells

    Article • eLife, September 2015, eLife

    Linda Wordeman, Distinguished Professor L. Fernando Santana

  24. The long and winding road home: How junctin and triadin find their way to the junctional SR

    Article • Journal of Molecular and Cellular Cardiology, April 2015, Elsevier

    Distinguished Professor L. Fernando Santana

  25. Graded Ca 2+ /calmodulin-dependent coupling of voltage-gated Ca V 1.2 channels

    Article • eLife, February 2015, eLife

    Distinguished Professor L. Fernando Santana

  26. AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension

    Article • Science Signaling, July 2014, American Association for the Advancement of Science

    Distinguished Professor L. Fernando Santana

  27. Microtubule-Mediated Defects in Junctophilin-2 Trafficking Contribute to Myocyte Transverse-Tubule Remodeling and Ca 2+ Handling Dysfunction in Heart Failure

    Article • Circulation, April 2014, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  28. Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle

    Article • Journal of General Physiology, April 2014, Rockefeller University Press

    Distinguished Professor L. Fernando Santana

  29. Dystrophin-deficient cardiomyocytes derived from human urine: New biologic reagents for drug discovery

    Article • Stem Cell Research, March 2014, Elsevier

    Distinguished Professor L. Fernando Santana

  30. AKAP150 Contributes to Enhanced Vascular Tone by Facilitating Large-Conductance Ca 2+ -Activated K + Channel Remodeling in Hyperglycemia and Diabetes Mellitus

    Article • Circulation Research, February 2014, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  31. Cellular mechanisms of ventricular arrhythmias in a mouse model of Timothy syndrome (long QT syndrome 8)

    Article • Journal of Molecular and Cellular Cardiology, January 2014, Elsevier

    Distinguished Professor L. Fernando Santana

  32. Down‐regulation of CaV1.2 channels during hypertension: how fewer CaV1.2 channels allow more Ca2+ into hypertensive arterial smooth muscle

    Article • The Journal of Physiology, November 2013, Wiley

    Distinguished Professor L. Fernando Santana

  33. Regulation of L-type calcium channel sparklet activity by c-Src and PKC-α

    Article • AJP Cell Physiology, September 2013, American Physiological Society

    Distinguished Professor L. Fernando Santana

  34. CaV1.2 sparklets in heart and vascular smooth muscle

    Article • Journal of Molecular and Cellular Cardiology, May 2013, Elsevier

    Distinguished Professor L. Fernando Santana

  35. A Ca2+- and PKC-driven regulatory network in airway smooth muscle

    Article • Journal of General Physiology, January 2013, Rockefeller University Press

    Distinguished Professor L. Fernando Santana

  36. Anchored phosphatases modulate glucose homeostasis

    Article • The EMBO Journal, November 2012, Springer Science + Business Media

    Distinguished Professor L. Fernando Santana

  37. Adding Accessories for Hypertension

    Article • Hypertension, October 2012, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  38. Anchored phosphatases modulate glucose homeostasis

    Article • The EMBO Journal, August 2012, Springer Science + Business Media

    Distinguished Professor L. Fernando Santana

  39. Cardiomyocyte-Specific Expression of Lamin A Improves Cardiac Function in Lmna−/− Mice

    Article • PLoS ONE, August 2012, PLOS

    Distinguished Professor L. Fernando Santana

  40. L-Type Ca2+ Channel Function During Timothy Syndrome

    Article • Trends in Cardiovascular Medicine, April 2012, Elsevier

    Distinguished Professor L. Fernando Santana

  41. Ca 2+ signaling amplification by oligomerization of L-type Ca v 1.2 channels

    Article • Proceedings of the National Academy of Sciences, January 2012, Proceedings of the National Academy of Sciences

    Distinguished Professor L. Fernando Santana

  42. Relationship between Ca2+sparklets and sarcoplasmic reticulum Ca2+load and release in rat cerebral arterial smooth muscle

    Article • AJP Heart and Circulatory Physiology, December 2011, American Physiological Society

    Distinguished Professor L. Fernando Santana

  43. An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria

    Article • Proceedings of the National Academy of Sciences, November 2011, Proceedings of the National Academy of Sciences

    Distinguished Professor L. Fernando Santana

  44. Restoration of Normal L-Type Ca 2+ Channel Function During Timothy Syndrome by Ablation of an Anchoring Protein

    Article • Circulation Research, July 2011, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  45. Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy

    Article • Journal of the American College of Cardiology, June 2011, Elsevier

    Distinguished Professor L. Fernando Santana

  46. Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure

    Article • Circulation Research, April 2011, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  47. Dynamic Changes in Sarcoplasmic Reticulum Structure in Ventricular Myocytes

    Article • BioMed Research International, January 2011, Wiley

    Distinguished Professor L. Fernando Santana

  48. Eosinophil Cysteinyl Leukotriene Synthesis Mediated by Exogenous Secreted Phospholipase A2 Group X

    Article • Journal of Biological Chemistry, December 2010, Elsevier

    Distinguished Professor L. Fernando Santana

  49. How does the shape of the cardiac action potential control calcium signaling and contraction in the heart?

    Article • Journal of Molecular and Cellular Cardiology, December 2010, Elsevier

    Distinguished Professor L. Fernando Santana

  50. Sympathetic Stimulation of Adult Cardiomyocytes Requires Association of AKAP5 With a Subpopulation of L-Type Calcium Channels

    Article • Circulation Research, September 2010, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  51. Phosphodiesterase 8A (PDE8A) regulates excitation–contraction coupling in ventricular myocytes

    Article • Journal of Molecular and Cellular Cardiology, August 2010, Elsevier

    Distinguished Professor L. Fernando Santana

  52. Natural inequalities: why some L-type Ca2+ channels work harder than others

    Article • Journal of General Physiology, July 2010, Rockefeller University Press

    Distinguished Professor L. Fernando Santana

  53. Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure

    Article • AJP Heart and Circulatory Physiology, May 2010, American Physiological Society

    Distinguished Professor L. Fernando Santana

  54. A-Kinase Anchoring Proteins

    Article • Circulation, March 2010, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  55. Increased Coupled Gating of L-Type Ca 2+ Channels During Hypertension and Timothy Syndrome

    Article • Circulation Research, March 2010, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  56. Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells

    Article • AJP Cell Physiology, February 2010, American Physiological Society

    Distinguished Professor L. Fernando Santana

  57. Myostatin represses physiological hypertrophy of the heart and excitation–contraction coupling

    Article • The Journal of Physiology, October 2009, Wiley

    Distinguished Professor L. Fernando Santana

  58. Molecular and biophysical mechanisms of Ca2+ sparklets in smooth muscle

    Article • Journal of Molecular and Cellular Cardiology, October 2009, Elsevier

    Distinguished Professor L. Fernando Santana

  59. Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

    Article • Circulation, June 2009, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  60. Local Control of Excitation-Contraction Coupling in Human Embryonic Stem Cell-Derived Cardiomyocytes

    Article • PLoS ONE, April 2009, PLOS

    Distinguished Professor L. Fernando Santana

  61. NFATc3-dependent loss of Ito gradient across the left ventricular wall during chronic β adrenergic stimulation

    Article • Journal of Molecular and Cellular Cardiology, February 2009, Elsevier

    Distinguished Professor L. Fernando Santana

  62. The control of Ca 2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension

    Article • Proceedings of the National Academy of Sciences, October 2008, Proceedings of the National Academy of Sciences

    Distinguished Professor L. Fernando Santana

  63. NFAT-Dependent Excitation–Transcription Coupling in Heart

    Article • Circulation Research, September 2008, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  64. CALCIUM SPARKLETS IN ARTERIAL SMOOTH MUSCLE

    Article • Clinical and Experimental Pharmacology and Physiology, August 2008, Wiley

    Distinguished Professor L. Fernando Santana

  65. AKAP150 Is Required for Stuttering Persistent Ca 2+ Sparklets and Angiotensin II–Induced Hypertension

    Article • Circulation Research, February 2008, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  66. SMAKing Ca2+ sparks in arterial myocytes

    Article • The Journal of Physiology, September 2007, Wiley

    Distinguished Professor L. Fernando Santana

  67. Cav1.3 channels produce persistent calcium sparklets, but Cav1.2 channels are responsible for sparklets in mouse arterial smooth muscle

    Article • AJP Heart and Circulatory Physiology, September 2007, American Physiological Society

    Distinguished Professor L. Fernando Santana

  68. Calcium sparklets regulate local and global calcium in murine arterial smooth muscle

    Article • The Journal of Physiology, February 2007, Wiley

    Distinguished Professor L. Fernando Santana

  69. Activation of NFATc3 Down-regulates the β1 Subunit of Large Conductance, Calcium-activated K+ Channels in Arterial Smooth Muscle and Contributes to Hypertension

    Article • Journal of Biological Chemistry, February 2007, Elsevier

    Distinguished Professor L. Fernando Santana

  70. Phosphoinositide 3-Kinase Binds to TRPV1 and Mediates NGF-stimulated TRPV1 Trafficking to the Plasma Membrane

    Article • Journal of General Physiology, October 2006, Rockefeller University Press

    Distinguished Professor L. Fernando Santana

  71. Kv2 channels oppose myogenic constriction of rat cerebral arteries

    Article • AJP Cell Physiology, August 2006, American Physiological Society

    Distinguished Professor L. Fernando Santana

  72. Differential Calcineurin/NFATc3 Activity Contributes to the I to Transmural Gradient in the Mouse Heart

    Article • Circulation Research, May 2006, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  73. Mechanisms Underlying Heterogeneous Ca2+ Sparklet Activity in Arterial Smooth Muscle

    Article • Journal of General Physiology, May 2006, Rockefeller University Press

    Distinguished Professor L. Fernando Santana

  74. Mechanisms underlying variations in excitation–contraction coupling across the mouse left ventricular free wall

    Article • The Journal of Physiology, March 2006, Wiley

    Distinguished Professor L. Fernando Santana

  75. On the Loose: Uncaging Ca2+-induced Ca2+ Release in Smooth Muscle

    Article • Journal of General Physiology, February 2006, Rockefeller University Press

    Distinguished Professor L. Fernando Santana

  76. Constitutively active L-type Ca 2+ channels

    Article • Proceedings of the National Academy of Sciences, July 2005, Proceedings of the National Academy of Sciences

    Distinguished Professor L. Fernando Santana

  77. Sodium Current and Arrhythmogenesis in Heart Failure

    Article • Heart Failure Clinics, July 2005, Elsevier

    Distinguished Professor L. Fernando Santana

  78. Alterations in Early Action Potential Repolarization Causes Localized Failure of Sarcoplasmic Reticulum Ca 2+ Release

    Article • Circulation Research, March 2005, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  79. NFATc3 Regulates Kv2.1 Expression in Arterial Smooth Muscle

    Article • Journal of Biological Chemistry, November 2004, Elsevier

    Distinguished Professor L. Fernando Santana

  80. NFATc3-Induced Reductions in Voltage-Gated K + Currents After Myocardial Infarction

    Article • Circulation Research, May 2004, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  81. Downregulation of the BK Channel β1 Subunit in Genetic Hypertension

    Article • Circulation Research, November 2003, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  82. Modulation of the molecular composition of large conductance, Ca2+ activated K+ channels in vascular smooth muscle during hypertension

    Article • Journal of Clinical Investigation, September 2003, American Society for Clinical Investigation

    Distinguished Professor L. Fernando Santana

  83. Functional coupling of calcineurin and protein kinase A in mouse ventricular myocytes

    Article • The Journal of Physiology, October 2002, Wiley

    Distinguished Professor L. Fernando Santana

  84. Probing the Effects of Membrane Cholesterol in the Torpedo californica Acetylcholine Receptor and the Novel Lipid-exposed Mutation αC418W in XenopusOocytes

    Article • Journal of Biological Chemistry, December 2001, Elsevier

    Distinguished Professor L. Fernando Santana

  85. Role of Sodium Channel Deglycosylation in the Genesis of Cardiac Arrhythmias in Heart Failure

    Article • Journal of Biological Chemistry, July 2001, Elsevier

    Distinguished Professor L. Fernando Santana

  86. Ca 2+ Flux Through Promiscuous Cardiac Na + Channels: Slip-Mode Conductance

    Article • Science, February 1998, American Association for the Advancement of Science

    Distinguished Professor L. Fernando Santana

  87. Calcium Sparks and Excitation–Contraction Coupling in Phospholamban‐Deficient Mouse Ventricular Myocytes

    Article • The Journal of Physiology, August 1997, Wiley

    Distinguished Professor L. Fernando Santana

  88. Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure

    Article • Science, May 1997, American Association for the Advancement of Science

    Distinguished Professor L. Fernando Santana

  89. Two mechanisms of quantized calcium release in skeletal muscle

    Article • Nature, February 1996, Springer Science + Business Media

    Distinguished Professor L. Fernando Santana