What is it about?
Fast scanning calorimetry can be used to characterize microcrystal of nanogram weight from the ordinary microcrystalline powder. Different polymorphs are discriminated by different meltintg points and different numbers of phase transitions.
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Why is it important?
Calorimetric characterization of polymorphs is the most sample consuming method of polymorph screening. The fast scanning calorimetry is free from this setback, which is important for very expensive compounds prepared in very small amounts
Perspectives
The experimental results and approaches proposed in this work can be used to boost the efficiency of polymorph screening for medical drugs, active pharmaceutical ingredients (API) and new compounds for medical applications
Valery Gorbatchuk
Kazan Federal University
Read the Original
This page is a summary of: Using fast scanning calorimetry to detect guest-induced polymorphism by irreversible phase transitions in the nanogram scale, CrystEngComm, January 2019, Royal Society of Chemistry,
DOI: 10.1039/c8ce01865k.
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