What is it about?
Spatiotemporal control of cellular chemistry provides an experimental technique that can be used to better understand the mechanisms of cellular physiology. Caged compounds are molecules that can be used to control chemical reactions in cells with high spatial and temporal resolution. We have developed a synthetic platform that facilitates the preparation of caged compounds with novel properties.
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Why is it important?
We demonstrate a method for the synthesis of clickable caged compounds that can be modified easily with various functional units via copper(I)-catalyzed Huisgen cyclization. Additional properties such as water solubility and cell targeting ability can be readily incorporated into clickable caged compounds. Thus, the present protocol can be a solution for the lack of structural diversity in the available caged compounds.
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This page is a summary of: A clickable caging group as a new platform for modular caged compounds with improved photochemical properties, Chemical Communications, January 2019, Royal Society of Chemistry,
DOI: 10.1039/c8cc07981a.
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