All Stories

  1. Chemo-optogenetic Protein Translocation System Using a Photoactivatable Self-Localizing Ligand

    Article • ACS Chemical Biology, August 2021, American Chemical Society (ACS)

    Professor Toshiaki Furuta

  2. Design and synthesis of gene-directed caged cyclic nucleotides exhibiting cell type selectivity

    Article • Chemical Communications, January 2021, Royal Society of Chemistry

    Professor Toshiaki Furuta

  3. Synthesis of hydrophilic caged DAG-lactones for chemical biology applications

    Article • Organic & Biomolecular Chemistry, January 2020, Royal Society of Chemistry

    Professor Toshiaki Furuta

  4. Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds

    Article • Journal of Visualized Experiments, October 2019, MyJove Corporation

    Professor Toshiaki Furuta

  5. Synthesis of new optochemical tools

    Article • Chemical Communications, January 2019, Royal Society of Chemistry

    Professor Toshiaki Furuta, Colin Caveney (Kudos Admin)

  6. 7-Hydroxy-N-Methylquinolinium Chromophore: A Photolabile Protecting Group for Blue-Light Uncaging

    Article • Organic Letters, June 2018, American Chemical Society (ACS)

    Professor Toshiaki Furuta

  7. Red fluorescent cAMP indicator with increased affinity and expanded dynamic range

    Article • Scientific Reports, January 2018, Springer Science + Business Media

    Professor Toshiaki Furuta

  8. Utilization of the Heavy Atom Effect for the Development of a Photosensitive 8-Azacoumarin-Type Photolabile Protecting Group

    Article • Organic Letters, October 2015, American Chemical Society (ACS)

    Professor Toshiaki Furuta

  9. A double bond-conjugated dimethylnitrobenzene-type photolabile nitric oxide donor with improved two-photon cross section

    Article • Bioorganic & Medicinal Chemistry Letters, August 2015, Elsevier

    Professor Toshiaki Furuta

  10. Development of the 8-aza-3-bromo-7-hydroxycoumarin-4-ylmethyl group as a new entry of photolabile protecting groups

    Article • Tetrahedron, July 2014, Elsevier

    Professor Toshiaki Furuta

  11. Isostere-Based Design of 8-Azacoumarin-Type Photolabile Protecting Groups: A Hydrophilicity-Increasing Strategy for Coumarin-4-ylmethyls

    Article • Organic Letters, February 2014, American Chemical Society (ACS)

    Professor Toshiaki Furuta

  12. Preparation of photo-caged DNA molecules

    Article • Chemical Communications, January 2014, Royal Society of Chemistry

    Professor Toshiaki Furuta

  13. Synthesis of nucleobase-caged peptide nucleic acids having improved photochemical properties

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Professor Toshiaki Furuta

  14. Design, Synthesis, and Photochemistry of Modular Caging Groups for Photoreleasable Nucleotides

    Article • Organic Letters, December 2012, American Chemical Society (ACS)

    Professor Toshiaki Furuta

  15. Designing Caged Compounds for Spatiotemporal Control of Cellular Chemistry

    Article • Journal of Synthetic Organic Chemistry Japan, January 2012, The Society of Synthetic Organic Chemistry, Japan

    Professor Toshiaki Furuta

  16. Synthetic Caged DAG-lactones for Photochemically Controlled Activation of Protein Kinase C

    Article • ChemBioChem, January 2011, Wiley

    Professor Toshiaki Furuta

  17. Photocontrolled Compound Release System Using Caged Antimicrobial Peptide

    Article • Journal of the American Chemical Society, July 2010, American Chemical Society (ACS)

    Professor Toshiaki Furuta

  18. ChemInform Abstract: Anthraquinon-2-ylmethoxycarbonyl (Aqmoc): A New Photochemically Removable Protecting Group for Alcohols.

    Article • ChemInform, May 2010, Wiley

    Professor Toshiaki Furuta

  19. ChemInform Abstract: Design, Synthesis, Photochemical Properties and Cytotoxic Activities of Water-Soluble Caged L-Leucyl-L-leucine Methyl Esters that Control Apoptosis of Immune Cells.

    Article • ChemInform, May 2010, Wiley

    Professor Toshiaki Furuta

  20. Development and photo-responsive peptide bond cleavage reaction of two-photon near-infrared excitation-responsive peptide

    Article • Tetrahedron Letters, May 2010, Elsevier

    Professor Toshiaki Furuta

  21. Light-activated gene expression from site-specific caged DNA with a biotinylated photolabile protection group

    Article • Chemical Communications, January 2010, Royal Society of Chemistry

    Professor Toshiaki Furuta

  22. Multiple bond-conjugated photoinduced nitric oxide releaser working with two-photon excitation

    Article • Bioorganic & Medicinal Chemistry Letters, January 2010, Elsevier

    Professor Toshiaki Furuta

  23. A caged phosphopeptide-based approach for photochemical activation of kinases in living cells

    Article • Journal of Bioscience and Bioengineering, November 2009, Elsevier

    Professor Toshiaki Furuta

  24. The E1 Mechanism in Photo-Induced β-Elimination Reactions for Green-to-Red Conversion of Fluorescent Proteins

    Article • Chemistry & Biology, November 2009, Elsevier

    Professor Toshiaki Furuta

  25. Photoinduced Nitric Oxide Release from a Hindered Nitrobenzene Derivative by Two-Photon Excitation

    Article • Journal of the American Chemical Society, June 2009, American Chemical Society (ACS)

    Professor Toshiaki Furuta

  26. Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells

    Article • Nature Immunology, May 2009, Springer Science + Business Media

    Professor Toshiaki Furuta

  27. Designing new caged probes for photomanipulation

    Article • Neuroscience Research, January 2009, Elsevier

    Professor Toshiaki Furuta

  28. A Caged Phosphopeptide‐Based Approach for Photochemical Activation of Kinases in Living Cells

    Article • ChemBioChem, July 2008, Wiley

    Professor Toshiaki Furuta

  29. Synthesis and photochemical properties of a light-activated fluorophore to label His-tagged proteins

    Article • Chemical Communications, January 2008, Royal Society of Chemistry

    Professor Toshiaki Furuta

  30. A bromocoumarin-based linker for synthesis of photocleavable peptidoconjugates with high photosensitivity

    Article • Chemical Communications, January 2008, Royal Society of Chemistry

    Professor Toshiaki Furuta

  31. Phototriggers for Nucleobases with Improved Photochemical Properties

    Article • Organic Letters, November 2007, American Chemical Society (ACS)

    Professor Toshiaki Furuta

  32. Crystallographic Evidence for Water-assisted Photo-induced Peptide Cleavage in the Stony Coral Fluorescent Protein Kaede

    Article • Journal of Molecular Biology, September 2007, Elsevier

    Professor Toshiaki Furuta

  33. New Photoremovable Protecting Groups for Carboxylic Acids with High Photolytic Efficiencies at Near-UV Irradiation. Application to the Photocontrolled Release of L-Glutamate

    Article • ChemBioChem, September 2006, Wiley

    Professor Toshiaki Furuta

  34. Lhx2 mediates the activity of Six3 in zebrafish forebrain growth

    Article • Developmental Biology, November 2005, Elsevier

    Professor Toshiaki Furuta

  35. Photoremovable Protecting Groups Used for the Caging of Biomolecules

    Article • October 2005, Wiley

    Professor Toshiaki Furuta

  36. Correction: Real-time analysis of the role of Ca2+ in flagellar movement and motility in single sea urchin sperm

    Article • Journal of Cell Biology, September 2005, Rockefeller University Press

    Professor Toshiaki Furuta

  37. Real-time analysis of the role of Ca2+in flagellar movement and motility in single sea urchin sperm

    Article • Journal of Cell Biology, May 2005, Rockefeller University Press

    Professor Toshiaki Furuta

  38. Bhc-cNMPs as either Water-Soluble or Membrane-Permeant Photoreleasable Cyclic Nucleotides for both One- and Two-Photon Excitation

    Article • ChemBioChem, August 2004, Wiley

    Professor Toshiaki Furuta

  39. A sea urchin egg jelly peptide induces a cGMP-mediated decrease in sperm intracellular Ca2+ before its increase

    Article • Developmental Biology, August 2004, Elsevier

    Professor Toshiaki Furuta

  40. Controlling cellular systems with Bhc-caged compounds

    Article • TrAC Trends in Analytical Chemistry, July 2004, Elsevier

    Professor Toshiaki Furuta

  41. Photo-Mediated Gene Activation by Using Caged mRNA in Zebrafish Embryos

    Article • January 2004, Elsevier

    Professor Toshiaki Furuta

  42. Coumarin-4-ylmethoxycarbonyls as Phototriggers for Alcohols and Phenols

    Article • Organic Letters, December 2003, American Chemical Society (ACS)

    Professor Toshiaki Furuta

  43. Photo-Induced Peptide Cleavage in the Green-to-Red Conversion of a Fluorescent Protein

    Article • Molecular Cell, October 2003, Elsevier

    Professor Toshiaki Furuta

  44. Design, synthesis and photochemical properties of caged bile acids

    Article • Bioorganic & Medicinal Chemistry Letters, March 2003, Elsevier

    Professor Toshiaki Furuta

  45. Design, synthesis, photochemical properties and cytotoxic activities of water-Soluble caged l-Leucyl-l-leucine methyl esters that control apoptosis of immune cells

    Article • Bioorganic & Medicinal Chemistry, March 2002, Elsevier

    Professor Toshiaki Furuta

  46. Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos

    Article • Nature Genetics, July 2001, Springer Science + Business Media

    Professor Toshiaki Furuta

  47. Anthraquinon-2-ylmethoxycarbonyl (Aqmoc): A New Photochemically Removable Protecting Group for Alcohols

    Article • Organic Letters, June 2001, American Chemical Society (ACS)

    Professor Toshiaki Furuta

  48. Brominated 7-hydroxycoumarin-4-ylmethyls: Photolabile protecting groups with biologically useful cross-sections for two photon photolysis

    Article • Proceedings of the National Academy of Sciences, February 1999, Proceedings of the National Academy of Sciences

    Professor Toshiaki Furuta

  49. Correlation of Exciplex Formation with Ground State Conformations in Flexible Bichromophoric Esters: 2-(1-Pyrenyl)ethyl p-Cyanobenzoate and Its Model Compounds.

    Article • Bulletin of the Chemical Society of Japan, January 1999, Chemical Society of Japan

    Professor Toshiaki Furuta

  50. [3] New caged groups: 7-substituted coumarinylmethyl phosphate esters

    Article • January 1998, Elsevier

    Professor Toshiaki Furuta

  51. Synthesis and Cytotoxic Studies of 5-O-(β–Glucopyranosyl)-2-nitrobenzyl Cagedl-Leucyl-l-Leucine Methyl Ester with Increased Solubility in PBS Containing 1% DMSO

    Article • Biochemical and Biophysical Research Communications, April 1997, Elsevier

    Professor Toshiaki Furuta

  52. Acyloxycoumarinylmethyl-Caged cAMP, the Photolabile and Membrane-Permeable Derivative of cAMP That Effectively Stimulates Pigment-Dispersion Response of Melanophores

    Article • Biochemical and Biophysical Research Communications, November 1996, Elsevier

    Professor Toshiaki Furuta, Atsuya Momotake

  53. Synthesis, Photoreactivity and Cytotoxic Activity of Caged Compounds of L-Leucyl-L-Leucine Methyl Ester, an Apoptosis Inducer

    Article • Photochemistry and Photobiology, June 1996, Wiley

    Professor Toshiaki Furuta

  54. Activation of selenoglycosides by photoinduced electron transfer

    Article • Chemical Communications, January 1996, Royal Society of Chemistry

    Professor Toshiaki Furuta

  55. Rearrangement Approaches to Cyclic Skeletons. X. Pinacol-Type Rearrangement of 2-Substituted 1-Methoxybicyclo(2.2.2)oct-5-en-2-ols into Bicyclo(3.2.1)oct-6-en-2-ones. Remarkable Substituent Effects on Predominant Migration of the Unsaturated Bridge.

    Article • Bulletin of the Chemical Society of Japan, January 1996, Chemical Society of Japan

    Professor Toshiaki Furuta

  56. Synthesis of Caged Compounds of L-Leucyl-L-Leucine Methyl Ester, an Apoptosis Inducer, and Their Cytotoxic Activity

    Article • Biochemical and Biophysical Research Communications, August 1995, Elsevier

    Professor Toshiaki Furuta

  57. Photochemical Properties of New Photolabile cAMP Derivatives in a Physiological Saline Solution

    Article • The Journal of Organic Chemistry, June 1995, American Chemical Society (ACS)

    Professor Toshiaki Furuta

  58. (1-PYRENYL)METHYL CARBAMATES FOR FLUORESCENT “CAGED” AMINO ACIDS AND PEPTIDES

    Article • Photochemistry and Photobiology, May 1995, Wiley

    Professor Toshiaki Furuta

  59. Stereodivergent synthesis of two diastereoisomeric enoates by asymmetric horner–wadsworth–emmons reaction using a single chiral auxiliary

    Article • Journal of the Chemical Society Chemical Communications, January 1994, Royal Society of Chemistry

    Professor Toshiaki Furuta

  60. Direct esterification of phosphates with various halides and its application to synthesis of cAMP alkyl triesters

    Article • Journal of the Chemical Society Perkin Transactions 1, January 1993, Royal Society of Chemistry

    Professor Toshiaki Furuta

  61. New Photochemically Labile Protecting Group for Phosphates.

    Article • Chemistry Letters, January 1993, Chemical Society of Japan

    Professor Toshiaki Furuta

  62. A mild and selective method for ester hydrolysis

    Article • High Pressure Research, January 1993, Taylor & Francis

    Professor Toshiaki Furuta

  63. Synthesis of α-alkoxyalkyltributyllead compounds via the reaction of tributylplumbyllithium with α-chloroethers, and the conjugate addition of tributylplumbyllithium to enones

    Article • Journal of Organometallic Chemistry, January 1993, Elsevier

    Professor Toshiaki Furuta

  64. A new method for construction of cyclic enones via phosphonate anions

    Article • Heteroatom Chemistry, October 1992, Wiley

    Professor Toshiaki Furuta

  65. Stereocontrol of three contiguous chiral centers of brassinosteroid side chain by using .alpha.-alkoxy organoleads

    Article • The Journal of Organic Chemistry, May 1992, American Chemical Society (ACS)

    Professor Toshiaki Furuta

  66. Very high diastereofacial stereoselectivity in the α-methoxy organolead–aldehyde condensation. Stereocontrol of three contiguous chiral centres

    Article • Journal of the Chemical Society Chemical Communications, January 1992, Royal Society of Chemistry

    Professor Toshiaki Furuta

  67. Cleavage of esters under nearly neutral conditions at high pressure. Chemo- and regioselective hydrolysis in organic solvents

    Article • The Journal of Organic Chemistry, September 1991, American Chemical Society (ACS)

    Professor Toshiaki Furuta

  68. A multistep rearrangement from 2,2-disubstituted-1,3-cyclohexanediones to 3-substituted 2-cyclohexenones via phosphonate anions and its application to a formal synthesis of (.+-.)-.alpha.-acoradiene

    Article • The Journal of Organic Chemistry, June 1990, American Chemical Society (ACS)

    Professor Toshiaki Furuta

  69. Construction of fused-ring skeletons based on photochemical rearrangements of bicyclo[3.2.1]oct-6-en-2-ones and application to a total synthesis of (.+-.)-.DELTA.9(12)-capnellene

    Article • The Journal of Organic Chemistry, November 1989, American Chemical Society (ACS)

    Professor Toshiaki Furuta

  70. Triethylgallium mediated lactamization of .ALPHA.,.OMEGA.-amino carboxylic acids.

    Article • Chemistry Letters, January 1989, Chemical Society of Japan

    Professor Toshiaki Furuta

  71. Rearrangement approaches to cyclic skeletons. 6. Total synthesis of (.+-.)-ptilocaulin on the basis of formal bridgehead substitution and photochemical [1,3] acyl migration of a bicyclo[3.2.2]non-6-en-2-one system

    Article • The Journal of Organic Chemistry, August 1988, American Chemical Society (ACS)

    Professor Toshiaki Furuta

  72. Rearrangement approaches to cyclic skeletons. V.

    Article • Tetrahedron, January 1987, Elsevier

    Professor Toshiaki Furuta

  73. Cobalt carbonyl catalysed reaction of oxetanes with a hydrosilane and carbon monoxide

    Article • Journal of Organometallic Chemistry, March 1986, Elsevier

    Professor Toshiaki Furuta

  74. Total synthesis of (±)-ptilocaulin starting from tropolone

    Article • Journal of the Chemical Society Chemical Communications, January 1986, Royal Society of Chemistry

    Professor Toshiaki Furuta

  75. Rearrangement approaches to cyclic skeletons. III. Practical route to cis-bicyclo(4.3.0)non-4-en-7-ones based on photochemical (1,3) acyl migration of bicyclo(3.2.2)non-6-en-2-ones.

    Article • Bulletin of the Chemical Society of Japan, January 1986, Chemical Society of Japan

    Professor Toshiaki Furuta

  76. A total synthesis of (.+-.)-widdrol. Synthetic application of the formal bridgehead substitution of 1-methoxybicyclo(3.2.2)non-6-en-2-ones with alkyl groups.

    Article • Chemistry Letters, January 1986, Chemical Society of Japan

    Professor Toshiaki Furuta

  77. Photochemical rearrangement approach to the total synthesis of (±)-pinguisone and (±)-deoxopinguisone

    Article • Tetrahedron Letters, January 1985, Elsevier

    Professor Toshiaki Furuta