What is it about?
A microtubule motor protein is required to keep centrosomes together during interphase. If centrosomes come apart, the nucleus can become decentralized in position and compromise spindle position in the upcoming cell division.
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Why is it important?
1. Kif25 is the first bipolar tetrameric kinesin to be discovered that translocates toward the minus end of microtubules. 2. The discovery of this kinesin and characterization of its cellular activity solves a long-standing problem in the centrosome field: why microtubules are necessary to keep mother and daughter centrosomes tethered together during interphase. 3. This study also enlightens us as to why premature centrosome separation is deleterious for cells.
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This page is a summary of: The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation, Nature, March 2017, Nature,
DOI: 10.1038/ncb3486.
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