Publication
Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of ( E )-1-(4-((1 R ,2 S ,3 R )-1,2,3,4-Tetrahydroxybutyl)-1 H -imidazol-2-yl)ethanone Oxime (LX2931) and (1 R ,2 S ,3 R )-1-(2-(Isoxazol-3-yl)-1 H -imida...
Jeffrey T. Bagdanoff, Michael S. Donoviel, Amr Nouraldeen, Marianne Carlsen, Theodore C. Jessop, James Tarver, Saadat Aleem, Li Dong, Haiming Zhang, Lakmal Boteju, Jill Hazelwood, Jack Yan, Mark Bednarz, Suman Layek, Iris B. Owusu, Suma Gopinathan, Liam Moran, Zhong Lai, Jeff Kramer, S. David Kimball, Padmaja Yalamanchili, William E. Heydorn, Kenny S. Frazier, Barbara Brooks, Philip Brown, Alan Wilson, William K. Sonnenburg, Alan Main, Kenneth G. Carson, Tamas Oravecz, David J. Augeri
Journal of Medicinal Chemistry, December 2010, American Chemical Society (ACS)
DOI: 10.1021/jm101183p