Aantileishmanial activity of arylamine Mannich base derivatives

What is it about?

We present twenty arylaminoketone derivatives with a very interesting in vitro and in vivo efficacy against Trypanosoma cruzi that have now been studied against promastigote and amastigote forms of L. infantum, L. donovani and L. braziliensis strains. Six out of the twenty Mannich base-type derivatives showed high Selectivity Index in the amastigote form than the reference drug glucantime, good parasite infectivity rates and were substantially more active against the three Leishmania species tested than glucantime. These molecules could be potential candidates for Leishmaniasis chemotherapy.

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Why is it important?

We present twenty arylaminoketone derivatives with a very interesting antileishmanial activity that could be potential candidates for Leishmaniasis chemotherapy

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