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  1. Chalcogen Derivatives for the Treatment of African Trypanosomiasis: Biological Evaluation of Thio- and Seleno-Semicarbazones and Their Azole Derivatives

    Article • ACS Omega, June 2025, American Chemical Society (ACS)

    Professor Silvia Pérez-Silanes

  2. Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (S, Se) and Their Azole Derivatives against Chagas Disease

    Article • Journal of Medicinal Chemistry, November 2024, American Chemical Society (ACS)

    Professor Silvia Pérez-Silanes

  3. Promising aryl selenoate derivatives as antileishmanial agents and their effects on gene expression

    Article • Antimicrobial Agents and Chemotherapy, April 2024, ASM Journals

    Professor Silvia Pérez-Silanes

  4. Novel Pitolisant-Derived Sulfonyl Compounds for Alzheimer Disease

    Article • International Journal of Molecular Sciences, January 2024, MDPI AG

    Professor Silvia Pérez-Silanes

  5. Neglected Zoonotic Diseases: Advances in the Development of Cell-Penetrating and Antimicrobial Peptides against Leishmaniosis and Chagas Disease

    Article • Pathogens, July 2023, MDPI AG

    Professor Silvia Pérez-Silanes

  6. Neglected Zoonotic Diseases: Advances in the Development of Cell-Penetrating and Antimicrobial Peptides against Leishmaniosis and Chagas

    Article • June 2023, MDPI AG

    Professor Silvia Pérez-Silanes

  7. Potential of sulfur-selenium isosteric replacement as a strategy for the development of new anti-chagasic drugs

    Article • Acta Tropica, September 2022, Elsevier

    Professor Silvia Pérez-Silanes

  8. Examination of multiple Trypanosoma cruzi targets in a new drug discovery approach for Chagas disease

    Article • Bioorganic & Medicinal Chemistry, March 2022, Elsevier

    Professor Silvia Pérez-Silanes

  9. Advances in Drug Discovery against Neglected Tropical Diseases: Human African and American Trypanosomiasis

    Article • Current Medicinal Chemistry, November 2021, Bentham Science Publishers

    Professor amir azam, Professor Silvia Pérez-Silanes

  10. Design and synthesis of Mannich base-type derivatives containing imidazole and benzimidazole as lead compounds for drug discovery in Chagas Disease

    Article • European Journal of Medicinal Chemistry, November 2021, Elsevier

    Professor Silvia Pérez-Silanes

  11. Selenium as an interesting option for the treatment of Chagas disease: A review

    Article • European Journal of Medicinal Chemistry, November 2020, Elsevier

    Professor Silvia Pérez-Silanes

  12. The role of imidazole and benzimidazole heterocycles in Chagas disease: A review

    Article • European Journal of Medicinal Chemistry, November 2020, Elsevier

    Professor Silvia Pérez-Silanes

  13. Rational modification of Mannich base-type derivatives as novel antichagasic compounds: Synthesis, in vitro and in vivo evaluation

    Article • Bioorganic & Medicinal Chemistry, September 2019, Elsevier

    Professor Silvia Pérez-Silanes

  14. Antichagasic profile of a Series of Mannich Base‐Type Derivatives: Design, Synthesis, in vitro Evaluation, and Computational Studies Involving Iron Superoxide Dismutase

    Article • ChemistrySelect, July 2019, Wiley

    Professor Silvia Pérez-Silanes

  15. A step towards development of promising trypanocidal agents: Synthesis, characterization and in vitro biological evaluation of ferrocenyl Mannich base-type derivatives

    Article • European Journal of Medicinal Chemistry, February 2019, Elsevier

    Professor Silvia Pérez-Silanes

  16. Organometallic compounds in the discovery of new agents against kinetoplastid-caused diseases

    Article • European Journal of Medicinal Chemistry, July 2018, Elsevier

    Professor Silvia Pérez-Silanes

  17. Second Generation of Mannich Base-Type Derivatives with in Vivo Activity against Trypanosoma cruzi

    Article • Journal of Medicinal Chemistry, June 2018, American Chemical Society (ACS)

    Professor Silvia Pérez-Silanes

  18. Design, Synthesis, and Characterization of N-Oxide-Containing Heterocycles with in Vivo Sterilizing Antitubercular Activity

    Article • Journal of Medicinal Chemistry, October 2017, American Chemical Society (ACS)

    Professor Silvia Pérez-Silanes

  19. Development, validation and application of a GC–MS method for the simultaneous detection and quantification of neutral lipid species in Trypanosoma cruzi

    Article • Journal of Chromatography B, September 2017, Elsevier

    Professor Silvia Pérez-Silanes

  20. Aantileishmanial activity of arylamine Mannich base derivatives

    Article • Parasitology, August 2017, Cambridge University Press

    Professor Silvia Pérez-Silanes

  21. Trypanothione Reductase and Superoxide Dismutase as Current Drug Targets for Trypanosoma cruzi: An Overview of Compounds with Activity against Chagas Disease

    Article • Current Medicinal Chemistry, May 2017, Bentham Science Publishers

    Professor Silvia Pérez-Silanes

  22. Library of Seleno-Compounds as Novel Agents against Leishmania Species

    Article • Antimicrobial Agents and Chemotherapy, March 2017, ASM Journals

    Professor Daniel Plano Amatriain, Professor Silvia Pérez-Silanes

  23. A Comparative Study of Conventional and Microwave-Assisted Synthesis of Quinoxaline 1,4-di-N-oxideN-acylhydrazones Derivatives Designed as Antitubercular Drug Candidates

    Article • Journal of Heterocyclic Chemistry, March 2017, Wiley

    Professor Silvia Pérez-Silanes

  24. Correction to In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of New Arylamine Mannich Base-Type Derivatives

    Article • Journal of Medicinal Chemistry, March 2017, American Chemical Society (ACS)

    Professor Silvia Pérez-Silanes

  25. In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of New Arylamine Mannich Base-Type Derivatives

    Article • Journal of Medicinal Chemistry, December 2016, American Chemical Society (ACS)

    Professor Silvia Pérez-Silanes

  26. Exploring the scope of new arylamino alcohol derivatives: Synthesis, antimalarial evaluation, toxicological studies, and target exploration

    Article • International Journal for Parasitology Drugs and Drug Resistance, December 2016, Elsevier

    Professor Silvia Pérez-Silanes

  27. Challenges in Chagas Disease Drug Discovery: A Review

    Article • Current Medicinal Chemistry, October 2016, Bentham Science Publishers

    Elsa Moreno de Viguri, Professor Silvia Pérez-Silanes

  28. Design and synthesis of novel quinoxaline derivatives as potential candidates for treatment of multidrug-resistant and latent tuberculosis

    Article • Bioorganic & Medicinal Chemistry Letters, May 2016, Elsevier

    Professor Silvia Pérez-Silanes

  29. Synthesis and biological evaluation of quinoxaline di- N -oxide derivatives with in vitro trypanocidal activity

    Article • Bioorganic & Medicinal Chemistry Letters, February 2016, Elsevier

    Professor Silvia Pérez-Silanes

  30. Synthesis, Biological Evaluation and Structure-Activity Relationships of New Quinoxaline Derivatives as Anti-Plasmodium falciparum Agents

    Article • Molecules, February 2014, MDPI AG

    Professor Silvia Pérez-Silanes

  31. Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents

    Article • European Journal of Medicinal Chemistry, August 2013, Elsevier

    Professor Silvia Pérez-Silanes

  32. New Amide Derivatives of Quinoxaline 1,4-di-N-Oxide with Leishmanicidal and Antiplasmodial Activities

    Article • Molecules, April 2013, MDPI AG

    Professor Silvia Pérez-Silanes

  33. Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives

    Article • Molecules, August 2012, MDPI AG

    Professor Silvia Pérez-Silanes

  34. New Quinoxaline Derivatives as Potential MT1 and MT2 Receptor Ligands

    Article • Molecules, June 2012, MDPI AG

    Professor Silvia Pérez-Silanes

  35. Novel sulfonylurea derivatives as H3 receptor antagonists. Preliminary SAR studies

    Article • European Journal of Medicinal Chemistry, June 2012, Elsevier

    Professor Silvia Pérez-Silanes

  36. Studies on Log Po/w of Quinoxaline di-N-Oxides: A Comparison of RP-HPLC Experimental and Predictive Approaches

    Article • Molecules, September 2011, MDPI AG

    Professor Silvia Pérez-Silanes

  37. New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities

    Article • Bioorganic & Medicinal Chemistry Letters, August 2011, Elsevier

    Professor Silvia Pérez-Silanes

  38. Aryl piperazine and pyrrolidine as antimalarial agents. Synthesis and investigation of structure–activity relationships

    Article • Experimental Parasitology, June 2011, Elsevier

    Professor Silvia Pérez-Silanes

  39. New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterium tuberculosis agents

    Article • Bioorganic & Medicinal Chemistry Letters, June 2011, Elsevier

    Professor Silvia Pérez-Silanes

  40. 3-TrifluoromethylquinoxalineN,N′-Dioxides as Anti-Trypanosomatid Agents. Identification of Optimal Anti-T. cruziAgents and Mechanism of Action Studies

    Article • Journal of Medicinal Chemistry, May 2011, American Chemical Society (ACS)

    Professor Silvia Pérez-Silanes

  41. Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action

    Article • Journal of Medicinal Chemistry, April 2011, American Chemical Society (ACS)

    Professor Silvia Pérez-Silanes

  42. Trypanocidal properties, structure–activity relationship and computational studies of quinoxaline 1,4-di-N-oxide derivatives

    Article • Experimental Parasitology, April 2011, Elsevier

    Professor Silvia Pérez-Silanes

  43. 1,4-Di-N-oxide quinoxaline-2-carboxamide: Cyclic voltammetry and relationship between electrochemical behavior, structure and anti-tuberculosis activity

    Article • Electrochimica Acta, March 2011, Elsevier

    Professor Silvia Pérez-Silanes

  44. Synthesis and Biological Evaluation of New Quinoxaline Derivatives as Antioxidant and Anti-Inflammatory Agents

    Article • Chemical Biology & Drug Design, February 2011, Wiley

    Professor Silvia Pérez-Silanes

  45. Building a MCHR1 homology model provides insight into the receptor–antagonist contacts that are important for the development of new anti-obesity agents

    Article • Bioorganic & Medicinal Chemistry, November 2010, Elsevier

    Professor Silvia Pérez-Silanes

  46. Synthesis and antimycobacterial activity of new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives

    Article • European Journal of Medicinal Chemistry, October 2010, Elsevier

    Professor Silvia Pérez-Silanes

  47. New 3-methylquinoxaline-2-carboxamide 1,4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents

    Article • Bioorganic & Medicinal Chemistry, April 2010, Elsevier

    Professor Silvia Pérez-Silanes

  48. New 1-Aryl-3-Substituted Propanol Derivatives as Antimalarial Agents

    Article • Molecules, October 2009, MDPI AG

    Professor Silvia Pérez-Silanes

  49. Heterocyclic-2-carboxylic Acid (3-Cyano-1,4-di-N-oxidequinoxalin-2-yl)amide Derivatives as Hits for the Development of Neglected Disease Drugs

    Article • Molecules, June 2009, MDPI AG

    Professor Silvia Pérez-Silanes

  50. Selective activity against Mycobacterium tuberculosis of new quinoxaline 1,4-di-N-oxides

    Article • Bioorganic & Medicinal Chemistry, January 2009, Elsevier

    Professor Silvia Pérez-Silanes

  51. Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates

    Article • Bioorganic & Medicinal Chemistry, January 2009, Elsevier

    Professor Silvia Pérez-Silanes

  52. Synthesis and structure–activity relationship of 3-phenylquinoxaline 1,4-di-N-oxide derivatives as antimalarial agents

    Article • European Journal of Medicinal Chemistry, September 2008, Elsevier

    Professor Silvia Pérez-Silanes

  53. Efficacy of Quinoxaline-2-Carboxylate 1,4-Di-N-Oxide Derivatives in Experimental Tuberculosis

    Article • Antimicrobial Agents and Chemotherapy, July 2008, ASM Journals

    Professor Silvia Pérez-Silanes

  54. In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide

    Article • Journal of Antimicrobial Chemotherapy, June 2008, Oxford University Press (OUP)

    Professor Silvia Pérez-Silanes

  55. Melanin-Concentrating Hormone Receptor 1 Antagonists: A New Perspective for the Pharmacologic Treatment of Obesity

    Article • Current Medicinal Chemistry, April 2008, Bentham Science Publishers

    Professor Silvia Pérez-Silanes

  56. Substitutions of Fluorine Atoms and Phenoxy Groups in the Synthesis of Quinoxaline 1,4-di-N-oxide Derivatives

    Article • Molecules, January 2008, MDPI AG

    Professor Silvia Pérez-Silanes

  57. Synthesis and Antiplasmodial Activity of 3-Furyl and 3-Thienylquinoxaline-2-carbonitrile 1,4-Di-N-oxide Derivatives

    Article • Molecules, January 2008, MDPI AG

    Professor Silvia Pérez-Silanes

  58. Unexpected Reduction of Ethyl 3-Phenylquinoxaline-2- carboxylate 1,4-Di-N-oxide Derivatives by Amines

    Article • Molecules, January 2008, MDPI AG

    Professor Silvia Pérez-Silanes

  59. Antiplasmodial structure–activity relationship of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-N-oxide derivatives

    Article • Experimental Parasitology, January 2008, Elsevier

    Professor Silvia Pérez-Silanes

  60. Synthesis and anti-inflammatory/antioxidant activities of some new ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their 4,5-dihydro-(1H)-pyrazole analogues

    Article • Bioorganic & Medicinal Chemistry Letters, December 2007, Elsevier

    Professor Silvia Pérez-Silanes

  61. Synthesis and Biological Evaluation of New 2-Arylcarbonyl-3-trifluoromethylquinoxaline 1,4-Di-N-oxide Derivatives and Their Reduced Analogues

    Article • Journal of Medicinal Chemistry, November 2007, American Chemical Society (ACS)

    Professor Silvia Pérez-Silanes

  62. Novel series of substituted biphenylmethyl urea derivatives as MCH-R1 antagonists for the treatment of obesity

    Article • Bioorganic & Medicinal Chemistry, June 2007, Elsevier

    Professor Silvia Pérez-Silanes

  63. Synthesis and evaluation of new hydrazide derivatives as neuropeptide Y Y5 receptor antagonists for the treatment of obesity

    Article • Bioorganic & Medicinal Chemistry, September 2004, Elsevier

    Professor Silvia Pérez-Silanes

  64. Synthesis of new thiophene and benzo[b]thiophene hydrazide derivatives as human NPY Y5 antagonists

    Article • Bioorganic & Medicinal Chemistry Letters, February 2004, Elsevier

    Professor Silvia Pérez-Silanes

  65. Synthesis and evaluation of new arylsulfonamidomethylcyclohexyl derivatives as human neuropeptide Y Y5 receptor antagonists for the treatment of obesity

    Article • European Journal of Medicinal Chemistry, January 2004, Elsevier

    Professor Silvia Pérez-Silanes

  66. Synthesis and Molecular Modeling of New 1-Aryl-3-[4-arylpiperazin-1-yl]-1-propane Derivatives with High Affinity at the Serotonin Transporter and at 5-HT1AReceptors

    Article • Journal of Medicinal Chemistry, September 2002, American Chemical Society (ACS)

    Professor Silvia Pérez-Silanes, Professor Santiago Ballaz

  67. New 1-Aryl-3-(4-arylpiperazin-1-yl)propane Derivatives, with Dual Action at 5-HT1ASerotonin Receptors and Serotonin Transporter, as a New Class of Antidepressants

    Article • Journal of Medicinal Chemistry, February 2001, American Chemical Society (ACS)

    Professor Silvia Pérez-Silanes

  68. New 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants

    Article • European Journal of Medicinal Chemistry, January 2001, Elsevier

    Professor Silvia Pérez-Silanes

  69. Design, synthesis and biological evaluation of new 3-[(4-aryl)piperazin-1-yl]-1-arylpropane derivatives as potential antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT1A receptor antagonism

    Article • Il Farmaco, May 2000, Elsevier

    Professor Silvia Pérez-Silanes