What is it about?
This paper dissects the amyloid nature of the myocilin misfolded state, which is believed to be the underlying cause of myocilin-associated glaucoma
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Why is it important?
We discovered two different peptide sequences within the myocilin olfactomedin domain that form bona fide amyloid fibrils. These amyloid structures are seen in the glaucoma-causing variants. By understanding the amyloid state of myocilin, it will be possible to develop an approach inhibit the interaction with small molecules that could serve as a therapeutic for this form of glaucoma.
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This page is a summary of: The Glaucoma-Associated Olfactomedin Domain of Myocilin Forms Polymorphic Fibrils That Are Constrained by Partial Unfolding and Peptide Sequence, Journal of Molecular Biology, February 2014, Elsevier,
DOI: 10.1016/j.jmb.2013.12.002.
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