All Stories

  1. Structure and stability of an apo thermophilic esterase that hydrolyzes polyhydroxybutyrate
  2. Structure and activity of a thermally stable mutant of Acanthamoeba actophorin
  3. Improved resolution crystal structure ofAcanthamoebaactophorin reveals structural plasticity not induced by microgravity
  4. Calcium-ligand variants of the myocilin olfactomedin propeller selected from invertebrate phyla reveal cross-talk with N-terminal blade and surface helices
  5. How does a protein’s structure spell the difference between health and disease? Our journey to understand glaucoma-associated myocilin
  6. Progress toward development of a proteostasis drug for myocilin-associated glaucoma
  7. Effects of protein engineering and rational mutagenesis on crystal lattice of single chain antibody fragments
  8. myocilin amyloid fibrils
  9. Non-Native Structural Properties of the Glaucoma-Associated Olfactomedin Domain of Myocilin Lead to Amyloid Fibrils
  10. New direction for glaucoma therapeutics: focus on the olfactomedin domain of myocilin
  11. Determination of Soluble and Membrane Protein Structures by X-Ray Crystallography
  12. Crystallization chaperone strategies for membrane proteins
  13. A Guided Tour of the Structural Biology of Gaucher Disease: Acid-β-Glucosidase and Saposin C
  14. Binding of 3,4,5,6-Tetrahydroxyazepanes to the Acid-β-glucosidase Active Site: Implications for Pharmacological Chaperone Design for Gaucher Disease
  15. The Stability of Myocilin Olfactomedin Domain Variants Provides New Insight into Glaucoma as a Protein Misfolding Disorder
  16. Biophysical Characterization of the Olfactomedin Domain of Myocilin, an Extracellular Matrix Protein Implicated in Inherited Forms of Glaucoma
  17. Rescue of Glaucoma-Causing Mutant Myocilin Thermal Stability by Chemical Chaperones
  18. Effects of pH and Iminosugar Pharmacological Chaperones on Lysosomal Glycosidase Structure and Stability
  19. Structure of acid β-glucosidase with pharmacological chaperone provides insight into Gaucher disease
  20. Characterization of the Particulate Methane Monooxygenase Metal Centers in Multiple Redox States by X-ray Absorption Spectroscopy
  21. X-ray Crystallography and Biological Metal Centers:  Is Seeing Believing?
  22. Crystal structure of a membrane-bound metalloenzyme that catalyses the biological oxidation of methane
  23. The quest for the particulate methane monooxygenase active site
  24. Biological Methane Oxidation: Regulation, Biochemistry, and Active Site Structure of Particulate Methane Monooxygenase
  25. Crystal Structure of a Novel Red Copper Protein from Nitrosomonas europaea,
  26. Synthesis, structure and magnetic properties of a chromium(III)nicotinamide complex [Cr3O(O2CCH3)6(na)3]+ (na=nicotinamide)