What is it about?

This study significantly contributes to our understanding of the multifaceted functions of survivin within the cell. Notably, we have uncovered its involvement in the epigenetic reprogramming of chromatin through its association with the polycomb repressor complex 2. Additionally, our investigation employed artificial intelligence to shed light on the specific protein interactions favored by survivin. Through our findings, we have demonstrated that the composition of these interacting partners plays a pivotal role in guiding survivin towards its intended targets.

Featured Image

Why is it important?

Survivin is primarily recognized for its crucial role in inhibiting programmed cell death and promoting cell division. It is widely acknowledged that survivin is abundantly produced in tumor cells, serving as a notable marker and potential therapeutic target for various diseases. However, recent research has unveiled an expanded range of roles played by survivin. Additionally, this research has enhanced our understanding of protein interactions by elucidating simple and readily predictable principles governing their dynamics.

Perspectives

We have recently embarked on the exploration of survivin's role in epigenetic modifications. Our primary objective is to comprehensively understand the underlying mechanisms driving these interactions. By doing so, we aspire to harness this knowledge to develop highly targeted treatments that exhibit enhanced efficacy against diverse diseases.

Professor Gergely Katona
University of Gothenburg

Read the Original

This page is a summary of: Survivin prevents the polycomb repressor complex 2 from methylating histone 3 lysine 27, iScience, July 2023, Elsevier,
DOI: 10.1016/j.isci.2023.106976.
You can read the full text:

Read

Contributors

The following have contributed to this page