Designing multiepitope subunit vaccine for Mycobacterium tuberculosis: Immunoinformatic approach

What is it about?

Tuberculosis is the most common cause of death among adults in the most economic age groups and immunocompromised patients. Increased transmission of Mycobacterium tuberculosis strains with drug resistance has complicated tuberculosis control and continue to pose a challenge to global public health. Mycobacterium tuberculosis has recently stimulated strong humoral immunity against adhesin such as hsp70. Vaccination is an effective means of protection and prevention of the spread of vaccinable preventable diseases. Bacillus Calmette–Guérin vaccine is currently the only vaccine used to protect against tuberculosis, hence the need to design more effective vaccines to protect adults and immunocompromised patients.

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Why is it important?

The designed vaccine construct is stable, immunogenic with high antigenic properties, non-allergenic in nature and safe for human use. Designing multiepitope subunit vaccine using the Immunoinformatics approach shows that it is feasible to produce effective vaccines against tuberculosis and save millions of lives from being lost every year