What is it about?
In this paper we described that genetic variation can affect the composition of blood, which then alters what proteins bind to the new, calcified nodules in drusen, the hallmark of macular degeneration.
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Why is it important?
The work highlights that genetic variation may not lead to a clear on/off result, but influences the amount of protein that is present in the blood. This than causes the accumulation of more or less proteins in a disease rather than the "it is there or not" phenomenon.
Perspectives
We need to be careful with our approaches to treatment as genetic modification may only bring about modest differences.
Dr Imre Lengyel
Queen's University Belfast
Read the Original
This page is a summary of: Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration, Experimental Eye Research, July 2018, Elsevier,
DOI: 10.1016/j.exer.2018.03.023.
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Contributors
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