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  1. Development of dual drug loaded-hydrogel scaffold combining microfluidics and coaxial 3D-printing for intravitreal implantation

    Article • International Journal of Pharmaceutics, November 2024, Elsevier

    Dr Imre Lengyel

  2. Metabolomic changes in tear fluid following zinc biofortification in the BiZiFED nutritional study: a feasibility study

    Article • Frontiers in Molecular Biosciences, September 2024, Frontiers

    Dr Imre Lengyel

  3. Bruch's Membrane Calcification in Pseudoxanthoma Elasticum

    Article • Ophthalmology Science, March 2024, Elsevier

    Dr Imre Lengyel

  4. Retina pathology as a target for biomarkers for Alzheimer's disease: Current status, ophthalmopathological background, challenges, and future directions

    Article • Alzheimer s & Dementia, November 2023, Wiley

    Dr Imre Lengyel

  5. Reduced Cone Density Is Associated with Multiple Sclerosis

    Article • Ophthalmology Science, September 2023, Elsevier

    Dr Imre Lengyel

  6. Artificial intelligence for biomarker discovery in Alzheimer's disease and dementia

    Article • Alzheimer s & Dementia, August 2023, Wiley

    Dr Imre Lengyel

  7. Two-Photon Excited Fluorescence Lifetime Imaging of Tetracycline-Labeled Retinal Calcification

    Article • Sensors, July 2023, MDPI AG

    Dr Imre Lengyel

  8. Editorial: Zinc in health and disease management

    Article • Frontiers in Nutrition, July 2023, Frontiers

    Dr Imre Lengyel

  9. Altered zinc homeostasis in a primary cell culture model of the retinal pigment epithelium

    Article • Frontiers in Nutrition, April 2023, Frontiers

    Dr Imre Lengyel

  10. Fluorescence Lifetime Imaging of Human Sub-RPE Calcification In Vitro Following Chlortetracycline Infusion

    Article • International Journal of Molecular Sciences, March 2023, MDPI AG

    Dr Imre Lengyel

  11. Optimised plasma sample preparation and LC‐MS analysis to support large‐scale proteomic analysis of clinical trial specimens: Application to the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial

    Article • PROTEOMICS - CLINICAL APPLICATIONS, March 2023, Wiley

    Dr Imre Lengyel

  12. Zinc Supplementation Induced Transcriptional Changes in Primary Human Retinal Pigment Epithelium: A Single-Cell RNA Sequencing Study to Understand Age-Related Macular Degeneration

    Article • Cells, February 2023, MDPI AG

    Dr Imre Lengyel

  13. Retinal Vascular Changes in Alzheimer's Dementia and Mild Cognitive Impairment: A Pilot Study Using Ultra-Widefield Imaging

    Article • Translational Vision Science & Technology, January 2023, Association for Research in Vision and Ophthalmology (ARVO)

    Dr Imre Lengyel

  14. Ocular Biomarkers for Alzheimer Disease Dementia

    Article • JAMA Ophthalmology, January 2023, American Medical Association (AMA)

    Dr Imre Lengyel

  15. Zinc supplementation induced transcriptional changes in primary human retinal pigment epithelium: a single cell RNA sequencing study to understand age-related macular degeneration

    Article • September 2022, Cold Spring Harbor Laboratory Press

    Dr Imre Lengyel

  16. Nuclear and cellular, micro and nano calcification in Alzheimer's disease patients and correlation to phosphorylated Tau

    Article • Acta Biomaterialia, April 2022, Elsevier

    Dr Imre Lengyel

  17. Re: Keenan et al.: Cluster Analysis and Genotype-Phenotype Assessment of Geographic Atrophy in Age-Related Macular Degeneration: AREDS2 Report 25 (Ophthalmology. 2021;5(11):1061-1073)

    Article • Ophthalmology Retina, April 2022, Elsevier

    Dr Imre Lengyel

  18. A 2,7-dichlorofluorescein derivative to monitor microcalcifications

    Article • Molecular Systems Design & Engineering, January 2022, Royal Society of Chemistry

    Dr Imre Lengyel

  19. A Potential New Role for Zinc in Age-Related Macular Degeneration through Regulation of Endothelial Fenestration

    Article • International Journal of Molecular Sciences, November 2021, MDPI AG

    Dr Imre Lengyel

  20. Development of a Genotype Assay for Age-Related Macular Degeneration

    Article • Ophthalmology, November 2021, Elsevier

    Dr Imre Lengyel

  21. Characterization of Calcium Phosphate Spherical Particles in the Subretinal Pigment Epithelium–Basal Lamina Space in Aged Human Eyes

    Article • Ophthalmology Science, September 2021, Elsevier

    Dr Imre Lengyel

  22. Comment and response to the article “The clinical relevance of visualizing the peripheral retina”by Nicola Quinn, Lajos Csincsik, Erin Flynn, Christine A. Curcio, Szilard Kiss, SriniVas R. Sadda, Ruth Hogg, Tunde Peto & Imre Lengyel.

    Article • Progress in Retinal and Eye Research, July 2021, Elsevier

    Dr Imre Lengyel

  23. Predicting Progression to Advanced Age-Related Macular Degeneration from Clinical, Genetic, and Lifestyle Factors Using Machine Learning

    Article • Ophthalmology, April 2021, Elsevier

    Dr Imre Lengyel

  24. Increased choroidal thickness in adults with Down syndrome

    Article • Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, January 2021, Wiley

    Dr Imre Lengyel

  25. Multiplex bioimaging of proteins-related to neurodegenerative diseases in eye sections by laser ablation - Inductively coupled plasma – Mass spectrometry using metal nanoclusters as labels

    Article • Talanta, January 2021, Elsevier

    Dr Imre Lengyel

  26. Retinal phenotyping of variants of Alzheimer's disease using ultra‐widefield retinal images

    Article • Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, January 2021, Wiley

    Dr Imre Lengyel

  27. Genotype- and Phenotype-Based Subgroups in Geographic Atrophy Secondary to Age-Related Macular Degeneration

    Article • Ophthalmology Retina, December 2020, Elsevier

    Dr Imre Lengyel

  28. Integrating Metabolomics, Genomics, and Disease Pathways in Age-Related Macular Degeneration

    Article • Ophthalmology, December 2020, Elsevier

    Dr Imre Lengyel

  29. A Multi-Omics Approach Identifies Key Regulatory Pathways Induced by Long-Term Zinc Supplementation in Human Primary Retinal Pigment Epithelium

    Article • Nutrients, October 2020, MDPI AG

    Dr Imre Lengyel

  30. Fluorescent Arylphosphonic Acids: Synergic Interactions between Bone and the Fluorescent Core

    Article • Chemistry - A European Journal, July 2020, Wiley

    Dr Imre Lengyel

  31. Nuclear and cellular, micro and nano calcification in Alzheimer’s disease patients and correlation to phosphorylated Tau

    Article • June 2020, Cold Spring Harbor Laboratory Press

    Dr Imre Lengyel

  32. Imaging hydroxyapatite in sub-retinal pigment epithelial deposits by fluorescence lifetime imaging microscopy with tetracycline staining

    Article • Journal of Biomedical Optics, April 2020, SPIE

    Dr Imre Lengyel

  33. Calcium, Diet, Imaging, and Age-Related Macular Degeneration

    Article • JAMA Ophthalmology, November 2019, American Medical Association (AMA)

    Dr Imre Lengyel

  34. Determination of Zn, Cu and Fe in human patients' serum using micro-sampling ICP-MS and sample dilution

    Article • Talanta, November 2019, Elsevier

    Dr Imre Lengyel

  35. Correction to: Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia

    Article • Acta Neuropathologica Communications, August 2019, Springer Science + Business Media

    Dr Imre Lengyel

  36. Retinal thickness as potential biomarker in posterior cortical atrophy and typical Alzheimer’s disease

    Article • Alzheimer s Research & Therapy, July 2019, Springer Science + Business Media

    Dr Imre Lengyel

  37. P1‐273: ASSESSING HETEROGENEITY OF ALZHEIMER'S DISEASE THROUGH THE EYE

    Article • Alzheimer s & Dementia, July 2019, Wiley

    Dr Imre Lengyel

  38. Zinc Nutrition and Inflammation in the Aging Retina

    Article • Molecular Nutrition & Food Research, June 2019, Wiley

    Dr Imre Lengyel

  39. Metabolomics in serum of patients with non-advanced age-related macular degeneration reveals aberrations in the glutamine pathway

    Article • PLoS ONE, June 2019, PLOS

    Dr Imre Lengyel

  40. THU0663 DO ANTIBODIES DIRECTED AGAINST HUMAN CILIARY BODY TISSUE PREDICT THE DEVELOPMENT OF UVEITIS IN JIA- A PRELIMINARY STUDY

    Article • June 2019, BMJ

    Dr Imre Lengyel

  41. The Placental Growth Factor Pathway and Its Potential Role in Macular Degenerative Disease

    Article • Current Eye Research, May 2019, Taylor & Francis

    Dr Imre Lengyel

  42. On the origin of proteins in human drusen: The meet, greet and stick hypothesis

    Article • Progress in Retinal and Eye Research, May 2019, Elsevier

    Dr Imre Lengyel

  43. Deep and Frequent Phenotyping study protocol: an observational study in prodromal Alzheimer’s disease

    Article • BMJ Open, March 2019, BMJ

    Dr Imre Lengyel

  44. Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration

    Article • Ophthalmology, March 2019, Elsevier

    Dr Imre Lengyel

  45. Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration

    Article • Ophthalmology, March 2019, Elsevier

    Dr Imre Lengyel

  46. Fluorescence Lifetime Imaging of Tetracycline-Stained Retinal Hydroxyapatite: An Early Biomarker for Age-Related Macular Degeneration?

    Article • Biophysical Journal, February 2019, Elsevier

    Dr Imre Lengyel

  47. Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia

    Article • Acta Neuropathologica Communications, January 2019, Springer Science + Business Media

    Dr Imre Lengyel

  48. Metabolomics and Age-Related Macular Degeneration

    Article • Metabolites, December 2018, MDPI AG

    Dr Imre Lengyel

  49. Calcified nodules in retinal drusen are associated with disease progression in age-related macular degeneration

    Article • Science Translational Medicine, November 2018, American Association for the Advancement of Science

    Dr Imre Lengyel

  50. A new perspective on lipid research in age-related macular degeneration

    Article • Progress in Retinal and Eye Research, November 2018, Elsevier

    Dr Imre Lengyel

  51. The clinical relevance of visualising the peripheral retina

    Article • Progress in Retinal and Eye Research, October 2018, Elsevier

    Dr Imre Lengyel

  52. Obesity, diabetes and zinc: A workshop promoting knowledge and collaboration between the UK and Israel, november 28–30, 2016 – Israel

    Article • Journal of Trace Elements in Medicine and Biology, September 2018, Elsevier

    Dr Imre Lengyel

  53. Precision medicine for age-related macular degeneration: current developments and prospects

    Article • Expert Review of Precision Medicine and Drug Development, July 2018, Taylor & Francis

    Professor Tunde Peto, Dr Imre Lengyel

  54. Genetic differences can cause changes in the level of several proteins in blood samples

    Article • Experimental Eye Research, July 2018, Elsevier

    Dr Imre Lengyel

  55. The effects of zinc supplementation on primary human retinal pigment epithelium

    Article • Journal of Trace Elements in Medicine and Biology, March 2018, Elsevier

    Dr Imre Lengyel

  56. Towards early detection of age-related macular degeneration with tetracyclines and FLIM

    Article • February 2018, SPIE

    Dr Imre Lengyel

  57. Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration

    Article • Survey of Ophthalmology, January 2018, Elsevier

    Dr Imre Lengyel

  58. Peripheral Retinal Imaging Biomarkers for Alzheimer’s Disease: A Pilot Study

    Article • Ophthalmic Research, January 2018, Karger Publishers

    Dr Imre Lengyel

  59. Localization of the zinc binding tubulin polymerization promoting protein in the mice and human eye

    Article • Journal of Trace Elements in Medicine and Biology, December 2017, Elsevier

    Dr Imre Lengyel

  60. Prevalence of Age-Related Macular Degeneration in Europe

    Article • Ophthalmology, December 2017, Elsevier

    vaibhav bhatia, Dr Imre Lengyel

  61. Changes in zinc status and zinc transporters expression in whole blood of patients with Systemic Inflammatory Response Syndrome (SIRS)

    Article • Journal of Trace Elements in Medicine and Biology, November 2017, Elsevier

    Dr Imre Lengyel

  62. Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model

    Article • Investigative Ophthalmology & Visual Science, February 2017, Association for Research in Vision and Ophthalmology (ARVO)

    Dr Imre Lengyel

  63. Main biomarkers associated with age-related plasma zinc decrease and copper/zinc ratio in healthy elderly from ZincAge study

    Article • Zeitschrift für Ernährungswissenschaft, July 2016, Springer Science + Business Media

    Dr Imre Lengyel

  64. RETINAL IMAGING IN POSTERIOR CORTICAL ATROPHY AND TYPICAL ALZHEIMER’S DISEASE

    Article • Alzheimer s & Dementia, July 2016, Elsevier

    Dr Imre Lengyel

  65. A Population-Based Ultra-Widefield Digital Image Grading Study for Age-Related Macular Degeneration–Like Lesions at the Peripheral Retina

    Article • Ophthalmology, July 2015, Elsevier

    Dr Imre Lengyel

  66. Retinal imaging in early-onset Alzheimer’s disease

    Article • Alzheimer s & Dementia, July 2015, Elsevier

    Dr Imre Lengyel

  67. Retinal nerve fibre layer (RNFL) thinning in genetic ftd

    Article • Alzheimer s & Dementia, July 2015, Elsevier

    Dr Imre Lengyel

  68. Correction for Thompson et al., Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye

    Article • Proceedings of the National Academy of Sciences, June 2015, Proceedings of the National Academy of Sciences

    Dr Imre Lengyel

  69. Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye

    Article • Proceedings of the National Academy of Sciences, January 2015, Proceedings of the National Academy of Sciences

    Dr Imre Lengyel

  70. Metals in age-related macular degeneration

    Article • Metallomics, January 2014, Oxford University Press (OUP)

    Dr Imre Lengyel

  71. Zinc-induced self-association of complement C3b and Factor H: Implications for inflammation and age-related macular degeneration

    Article • Molecular Immunology, December 2013, Elsevier

    Dr Imre Lengyel

  72. Zinc-induced Self-association of Complement C3b and Factor H: IMPLICATIONS FOR INFLAMMATION AND AGE-RELATED MACULAR DEGENERATION

    Article • Journal of Biological Chemistry, May 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Imre Lengyel

  73. Zinc Binding to the Tyr402 and His402 Allotypes of Complement Factor H: Possible Implications for Age-Related Macular Degeneration

    Article • Journal of Molecular Biology, May 2011, Elsevier

    Dr Imre Lengyel

  74. The His402 allotype of complement factor H show similar self-association to the Tyr402 allotype but exhibits greater self-association in the presence of zinc

    Article • Molecular Immunology, August 2010, Elsevier

    Dr Imre Lengyel

  75. Agreement between image grading of conventional (45°) and ultra wide-angle (200°) digital images in the macula in the Reykjavik eye study

    Article • Eye, June 2010, Nature

    Dr Imre Lengyel

  76. Bruch's membrane changes in transgenic mice overexpressing the human biglycan and apolipoprotein b-100 genes

    Article • Experimental Eye Research, August 2009, Elsevier

    Dr Imre Lengyel

  77. Uncontrolled Zinc- and Copper-Induced Oligomerisation of the Human Complement Regulator Factor H and Its Possible Implications for Function and Disease

    Article • Journal of Molecular Biology, December 2008, Elsevier

    Dr Imre Lengyel

  78. Uncontrolled zinc- and copper-induced oligomerisation of human complement factor H and its implications for age-related macular degeneration

    Article • Molecular Immunology, October 2008, Elsevier

    Dr Imre Lengyel

  79. Reply to “Comment on: “High concentration of zinc in sub-retinal pigment epithelial deposits” (Lengyel et al.) (Exp. Eye Res. 772–780, 84/4, 2007)”

    Article • Experimental Eye Research, May 2008, Elsevier

    Dr Imre Lengyel

  80. Comment on: “High concentration of zinc in sub-retinal pigment epithelial deposits” (Lengyel et al.) (Exp. Eye Res. 772–780, 84/4, 2007)

    Article • Experimental Eye Research, May 2008, Elsevier

    Dr Imre Lengyel

  81. Cure or cause: opposing roles for zinc in age-related macular degeneration

    Article • Expert Review of Ophthalmology, February 2008, Taylor & Francis

    Dr Imre Lengyel

  82. Bio‐avalibale zinc in the outer segments of short wavelength cones

    Article • Acta Ophthalmologica Scandinavica, September 2007, Wiley

    Dr Imre Lengyel

  83. High concentration of zinc in sub-retinal pigment epithelial deposits

    Article • Experimental Eye Research, April 2007, Elsevier

    Dr Imre Lengyel

  84. Partial and full agonism in endomorphin derivatives: Comparison by null and operational model

    Article • Peptides, June 2006, Elsevier

    Dr Imre Lengyel

  85. Autonomous activity of CaMKII is only transiently increased following the induction of long-term potentiation in the rat hippocampus

    Article • European Journal of Neuroscience, December 2004, Wiley

    Dr Imre Lengyel

  86. Association of Drusen Deposition with Choroidal Intercapillary Pillars in the Aging Human Eye

    Article • Investigative Ophthalmology & Visual Science, September 2004, Association for Research in Vision and Ophthalmology (ARVO)

    Dr Imre Lengyel

  87. Enhancement of NMDA responses by β-amyloid peptides in the hippocampus in vivo

    Article • Neuroreport, July 2004, Wolters Kluwer Health

    Dr Imre Lengyel

  88. Enhanced G-protein activation by a mixture of Abeta(25-35), Abeta(1-40/42) and zinc

    Article • Journal of Neurochemistry, June 2004, Wiley

    Dr Imre Lengyel, Professor Zoltan Molnar

  89. S100B-Mediated Inhibition of the Phosphorylation of GFAP Is Prevented by TRTK-12

    Article • Neurochemical Research, April 2004, Springer Science + Business Media

    Dr Imre Lengyel

  90. Molecular pathomechanisms of Alzheimer's disease

    Article • Journal of Molecular Structure THEOCHEM, December 2003, Elsevier

    Dr Imre Lengyel, Professor Zoltan Molnar

  91. Side Chain Modifications Change the Binding and Agonist Properties of Endomorphin 2

    Article • Biochemical and Biophysical Research Communications, January 2002, Elsevier

    Dr Imre Lengyel

  92. Influence of Degradation on Binding Properties and Biological Activity of Endomorphin 1

    Article • Biochemical and Biophysical Research Communications, June 2001, Elsevier

    Dr Imre Lengyel

  93. Receptor constants for endomorphin-1 and endomorphin-1-ol indicate differences in efficacy and receptor occupancy

    Article • European Journal of Pharmacology, June 2001, Elsevier

    Dr Imre Lengyel

  94. Preparation of specifically tritiated endomorphins

    Article • Journal of Labelled Compounds and Radiopharmaceuticals, April 2001, Wiley

    Dr Imre Lengyel

  95. Auto‐inhibition of Ca2+/calmodulin‐dependent protein kinase II by its ATP‐binding domain

    Article • Journal of Neurochemistry, February 2001, Wiley

    Dr Imre Lengyel

  96. Autonomous activity and autophosphorylation of CAMPK‐II in rat hippocampal slices: effects of tissue preparation

    Article • Journal of Neurochemistry, January 2001, Wiley

    Dr Imre Lengyel

  97. Modulation of the Phosphorylation and Activity of Calcium/Calmodulin‐Dependent Protein Kinase II by Zinc

    Article • Journal of Neurochemistry, August 2000, Wiley

    Dr Imre Lengyel

  98. Phosphorylation of a New Brain-specific Septin, G-septin, by cGMP-dependent Protein Kinase

    Article • Journal of Biological Chemistry, April 2000, Elsevier

    Dr Imre Lengyel

  99. Simultaneous measurement of tyrosine hydroxylase activity and phosphorylation in bovine adrenal chromaffin cells

    Article • Journal of Neuroscience Methods, March 1999, Elsevier

    Dr Imre Lengyel

  100. Phosphorylation of proteins in chick ciliary ganglion under conditions that induce long-lasting changes in synaptic transmission: phosphoprotein targets for nitric oxide action

    Article • Neuroscience, February 1999, Elsevier

    Dr Keith L. Brain, Dr Imre Lengyel

  101. α and β subunits of CaM-kinase II are localized in different neurons in chick ciliary ganglion

    Article • Neuroreport, August 1998, Wolters Kluwer Health

    Dr Imre Lengyel

  102. Characterization of protein kinase and phosphatase systems in chick ciliary ganglion

    Article • Neuroscience, January 1996, Elsevier

    Dr Imre Lengyel

  103. Calcium/Calmodulin‐Stimulated Protein Kinase II Is Present in Primary Cultures of Cerebral Endothelial Cells

    Article • Journal of Neurochemistry, May 1993, Wiley

    Dr Imre Lengyel, Dr Maria A Deli

  104. Pathological Phosphorylation Causes Neuronal Death: Effect of Okadaic Acid in Primary Culture of Cerebellar Granule Cells

    Article • Journal of Neurochemistry, October 1992, Wiley

    Dr Imre Lengyel

  105. Zinc can modulate the phosphorylation and activity of CAMK in freshly isolated rat brain capillaries

    Article • Neurochemistry International, January 1992, Elsevier

    Dr Imre Lengyel

  106. Chapter 26: Regulation of transendothelial transport in the cerebral microvessels: the role of second messengers-generating systems

    Article • January 1992, Elsevier

    Dr Imre Lengyel

  107. Early X-irradiation of rats—4. Decrease in phosphorylation of low molecular weight proteins in the olfactory bulb accompanies the loss of GABAergic microneurons

    Article • Neurochemistry International, January 1990, Elsevier

    Dr Imre Lengyel

  108. Kinetics of Protein Phosphorylation in Microvessels Isolated from Rat Brain: Modulation by Second Messengers

    Article • Journal of Neurochemistry, July 1988, Wiley

    Dr Imre Lengyel